Diethyl 2-{(dibenzylamino)[4-(trifluoromethyl)phenyl]methyl}malonate

In this investigation a series of new iso-urea ethers has been prepared by the general reaction of addition of alcohols to cyanamide in the presence of dry hydrogen chloride. Where the hydrochlorides of the iso-ureas were difficult to isolate and purify, conversion to the salicylates gave excellent results. The new iso-ureas were further characterized by condensing them with methyl malonate to form iso-urea salts of 2-alkoxy-barbituric acids, from which the acids themselves could be easily liberated by the addition of dilute mineral acid. A few open-chain acyl derivatives were also prepared.

Download Full-text

Dimethyl 2-{[2-(2-Methoxy-1-methoxycarbonyl-2-oxoethyl)-4,5,7-trimethoxy-3-(2,4,5-trimethoxyphenyl)-2,3-dihydro-1H-inden-1-yl]methyl}malonate

Molbank ◽

10.3390/m1107 ◽

2020 ◽

Vol 2020 (1) ◽

pp. M1107

Author(s):

Maksim A. Boichenko ◽

Alexey O. Chagarovskiy ◽

Victor B. Rybakov ◽

Igor V. Trushkov ◽

Olga A. Ivanova

Keyword(s):

Synthetic Approach ◽

Methyl Malonate

A simple synthetic approach to dimethyl 2-{[2-(2-methoxy-1-methoxycarbonyl-2-oxoethyl)-4,5,7-trimethoxy-3-(2,4,5-trimethoxyphenyl)-2,3-dihydro-1H-inden-1-yl]methyl}malonate has been developed, based on a B(C6F5)3-induced domino dimerization of 2-(2,4,5-trimethoxyphenyl)cyclopropane-1,1-diester.

Download Full-text

Insights into the Novel Hydrolytic Mechanism of a Diethyl 2-Phenyl-2-(2-arylacetoxy)methyl Malonate Ester-Based Microsomal Triglyceride Transfer Protein (MTP) Inhibitor

Chemical Research in Toxicology ◽

10.1021/tx300243v ◽

2012 ◽

Vol 25 (10) ◽

pp. 2138-2152 ◽

Cited By ~ 4

Author(s):

Tim Ryder ◽

Gregory S. Walker ◽

Theunis C. Goosen ◽

Roger B. Ruggeri ◽

Edward L. Conn ◽

...

Keyword(s):

Microsomal Triglyceride Transfer Protein ◽

The Novel ◽

Transfer Protein ◽

Methyl Malonate ◽

Hydrolytic Mechanism

Download Full-text

Nutritional Effects of -Methyl-Aspartate and Methyl-Malonate on Euglena gracilis and Ochromonas malhamensis.

Experimental Biology and Medicine ◽

10.3181/00379727-109-27156 ◽

1962 ◽

Vol 109 (1) ◽

pp. 213-215 ◽

Cited By ~ 1

Author(s):

H. A. Nathan ◽

H. B. Funk

Keyword(s):

Euglena Gracilis ◽

Methyl Aspartate ◽

Methyl Malonate ◽

Nutritional Effects

Download Full-text

ChemInform Abstract: Dimethyl Amino((phenylthio)methyl)malonate: A Useful C-3 Unit in a Mild, Direct Synthesis of Oxazole-4-carboxylates.

ChemInform ◽

10.1002/chin.199406140 ◽

2010 ◽

Vol 25 (6) ◽

pp. no-no

Author(s):

R. SHAPIRO

Keyword(s):

Direct Synthesis ◽

Methyl Malonate

Download Full-text

Michael additions to metallocene analogues of chalcones

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19870174 ◽

1987 ◽

Vol 52 (1) ◽

pp. 174-181 ◽

Cited By ~ 8

Author(s):

Jozef Federič ◽

Štefan Toma

Keyword(s):

Double Bond ◽

Chemical Shift ◽

Aryl Group ◽

Chemical Shift Difference ◽

Michael Additions ◽

Methyl Malonate

Eleven analogues of chalcones were synthesized; the variously substituted ferrocenyl, ruthenocenyl or η5-cyclopentadienyltricarbonylmanganese are attached to the β-carbon of the chalcone double bond. Methyl malonate was added to eight selected chalcones. The effect of an aryl group on the chemical shift difference of diastereotopic -COOCH3 groups is discussed. The Vilsmeier-Haack formylation was employed to prepare 1'-chloro and 1'-bromoferrocenecarbaldehydes. The synthesis of 2-chloroferrocenecarbaldehyde from 2-chloroferrocenylmethyldimethylamine is also described.

Download Full-text