BP neural network can learn and store a lot of input - output mode mapping, without prior reveal the mathematical equations describe the mapping. The model based on BP neural network algorithm is constituted by an input layer, output layer and one hidden layer, three-layer feed forward network. CRM is to acquire, maintain and increase the methods and processes of profitable customers. The core of CRM is the customer value management, customer value; it is divided into the de facto value, potential value and model value. The paper presents development of customer relationship management system in e-commerce based on BP neural network. The experiment shows BP is superior to RFCA in CRM.