Angiotensin II analogues with N-terminal lactam bridge cyclization: an overview on AT1receptor activation and tachyphylaxis

2016 ◽  
Vol 88 (5) ◽  
pp. 677-682
Author(s):  
Flávio Lopes Alves ◽  
Vani Xavier Oliveira ◽  
Antonio Miranda
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Ii Analogues ◽  
Lactam Bridge

Angiotensin II Analogues and Aldosterone Secretion in Sodium-Deficient Sheep

1976 ◽  
Vol 51 (s3) ◽  
pp. 325s-327s
Author(s):  
J. R. Blair-West ◽  
J. P. Coghlan ◽  
D. A. Denton ◽  
H. D. Niall ◽  
B. A. Scoggins ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Enzyme Inhibitor ◽  
Agonist Activity ◽  
Converting Enzyme ◽  
Aldosterone Secretion ◽  
Arterial Infusion ◽  
Sodium Deficiency ◽  
Converting Enzyme Inhibitor ◽  
Angiotensin Ii Analogues ◽  
Permissive Role

1. The angiotensin analogues Sar1-Ala8-angiotensin II (AII), Sar1-Ile8-AII, Sar1-Leu8-AII, Sar1-Thr8-AII, [Des1-Asp]-Ile8-AII and [Des1-Asp]-Sar2-Ile8-AII and converting enzyme inhibitor (SQ 80221) infused by intra-adrenal arterial infusion had no effect on aldosterone secretion in sodium-deficient sheep at doses in excess of those shown to block exogenous angiotensin II or III infusion. 2. It is suggested that the intrinsic agonist activity of the analogues may fulfil the requirements for a permissive role for angiotensin in the aldosterone response to sodium deficiency.

Synthesis and biological activities of [Aze7]- and [Pip7]-angiotensin II analogues

Peptides 1990 ◽  
1991 ◽  
pp. 659-660 ◽  
Author(s):  
J. Matsoukas ◽  
J. Hondrelis ◽  
G. Agelis ◽  
R. Yamdagni ◽  
R. C. Ganter ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Biological Activities ◽  
Angiotensin Ii Analogues

The Enzymatic Degradation of Angiotensin II Analogues by proteolytic enzyme in vitro

1972 ◽  
Vol 50 (2) ◽  
pp. 113-118 ◽  
Author(s):  
M. C. Carrara ◽  
D. Regoli ◽  
W. K. Park
Keyword(s):  
Amino Acids ◽  
Angiotensin Ii ◽  
Unnatural Amino Acids ◽  
Enzymatic Degradation ◽  
Leucine Aminopeptidase ◽  
Receptor Interaction ◽  
Angiotensin I ◽  
Peptide Receptor ◽  
Angiotensin Ii Analogues

Angiotensin II (ATII), angiotensin I (ATI), and Acpc analogues of ATII, 8-Achc-ATII, 8-D-Phe-ATII, and 8-Ala-ATII, were incubated in vitro with carboxypeptidase, chymotrypsin, and leucine-aminopeptidase in order to study the influence of unnatural amino acids (Acpc, Achc, and D-Phe) and of L-Ala on the activity of peptidases.Fragments occurring during the breakdown of peptides were demonstrated by paper chromatography in an ascending system.ATII and ATI are rapidly inactivated by carboxypeptidase and chymotrypsin, while the degradation by leucine-aminopeptidase is slower.Substitution of L-Phe with Acpc, Achc, D-Phe, or L-Ala in position 8 prevents the degradation by carboxypeptidase. Chymotrypsin degrades 3-Acpc-ATII and 5-Acpc-ATII but not 4-Acpc-ATII. The action of leucine-aminopeptidase is not influenced by substituting Acpc to each one of the first five amino acids composing the molecule of angiotensin.The possible implications of these findings for the peptide-receptor interaction is discussed.

Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-Chain bridges

2002 ◽  
Vol 12 (18) ◽  
pp. 2627-2633 ◽  
Author(s):  
Panagiota Roumelioti ◽  
Ludmila Polevaya ◽  
Panagiotis Zoumpoulakis ◽  
Nektarios Giatas ◽  
Ilze Mutule ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Biological Evaluation ◽  
Side Chain ◽  
Design Synthesis ◽  
Angiotensin Ii Analogues ◽  
Synthesis And Biological Evaluation

ChemInform Abstract: Synthesis of Angiotensin II Analogues Containing α-Alanine.

ChemInform ◽  
1987 ◽  
Vol 18 (22) ◽  
Author(s):  
R. PARUSZEWSKI ◽  
R. MATUSIAK ◽  
P. JAWORSKI ◽  
S. GUMULKA ◽  
I. WISNIEWSKA
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Ii Analogues

Angiotensin II Analogues Encompassing 5,9- and 5,10-Fused Thiazabicycloalkane Tripeptide Mimetics

1999 ◽  
Vol 42 (22) ◽  
pp. 4524-4537 ◽  
Author(s):  
Petra Johannesson ◽  
Gunnar Lindeberg ◽  
Weimin Tong ◽  
Adolf Gogoll ◽  
Barbro Synnergren ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Ii Analogues

Synthesis and biological activities of [β-malyl1]- and [β-Malyl1, Leu8]-angiotensin II analogues

1983 ◽  
Vol 39 (4) ◽  
pp. 353-355 ◽  
Author(s):  
P. Cordopatis ◽  
J. Matsoukas ◽  
A. Michel ◽  
J. Janen ◽  
D. Theodoropoulos
Keyword(s):  
Angiotensin Ii ◽  
Biological Activities ◽  
Angiotensin Ii Analogues

scholarly journals Comparison of two angiotensin II analogues in normal subjects and hypertensive patients.

1978 ◽  
Vol 25 (5) ◽  
pp. 447-452 ◽  
Author(s):  
TAKESHI HATA ◽  
TOSHIO OGIHARA ◽  
HIROSHI MIKAMI ◽  
MITSUAKI NAKAMARU ◽  
ANNA MARUYAMA ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Normal Subjects ◽  
Hypertensive Patients ◽  
Angiotensin Ii Analogues
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