The effect of water hardness on atopic eczema, skin barrier function: A systematic review, meta‐analysis

2020 ◽  
Author(s):  
Zarif K. Jabbar‐Lopez ◽  
Chuin Ying Ung ◽  
Helen Alexander ◽  
Nikeeta Gurung ◽  
Joanne Chalmers ◽  
...  
Keyword(s):  
Systematic Review ◽  
Atopic Eczema ◽  
Barrier Function ◽  
Meta Analysis ◽  
Skin Barrier ◽  
Water Hardness ◽  
Skin Barrier Function ◽  
Effect Of Water

scholarly journals The Effectivity of pH 4 Emulsion on Skin Barrier Function in The Elderly: A Systematic review and meta-analysis

2021 ◽  
pp. 40
Author(s):  
Keyword(s):  
Systematic Review ◽  
Qualitative Analysis ◽  
Barrier Function ◽  
Meta Analysis ◽  
Skin Barrier ◽  
The Elderly ◽  
Skin Surface ◽  
Skin Barrier Function ◽  
Effects Of Ph ◽  
The Mean

Background: The pH of the skin surface is elevated in the elderly therefore it may cause impaired barrier function manifest as various cutaneous abnormalities, including xerosis, pruritus, dermatitis, and skin infections. Consequently, skin care products for the elderly should contain moisturizing ingredients which are formulated to normalize the skin surface pH. Application of pH 4 emulsion is potentially beneficial to improve barrier function in the elderly and promoting skin health. We aimed to determine the difference of effectiveness of pH 4 emulsion compared to identical non pH 4 emulsion on decreasing TEWL in the elderly. A systematic review and meta-analysis was performed of randomized clinical trials assessing the effects of pH 4 emulsion on skin barrier function in the elderly. Methods: Medline Pubmed, Scopus, ProQuest, Cochrane library, ClinicalTrials.gov, the reference list, conference proceedings, researchers in the field of eligible studies were searched. Four studies (n=98 subjects) were included in qualitative analysis of which two studies (n=45 subjects) were included in the meta-analysis. The mean age of the participants was 71.1 years old. Interventions use the application of pH 4 water in oil emulsion (n=2) and pH 4 oil in water emulsion (n=2). Duration of intervention (24 hours-7 weeks) and outcomes of interest varied among included studies. Results: Pooling of data using random-effects model found lower TEWL score in the pH 4 emulsion than in non pH 4 emulsion, with no significant difference (overall effect mean difference -0.068, 95% confidence interval -0.485 – 0.348, p = 0.11, I2=60.1, two RCTs). In addition to that, the qualitative analysis found that the application of pH 4 emulsion increased stratum corneum hydration, decreased skin surface roughness and scaliness, decreased DASI, and improved ICLL length and lamellar organization. Conclusion: The meta-analysis result of the mean differences of TEWL scores lowering effect between pH 4 emulsion and non pH 4 emulsion is statistically inconclusive. This is despite the observation that the pH 4 emulsion appears to be more effective comparatively. The qualitative analysis found that the application of pH 4 emulsion had improved skin barrier function in the elderly. Larger scale, well-designed RCTs assessing the effects of pH 4 emulsion on skin barrier function in the elderly, are still needed.

scholarly journals 406 Skin barrier function genes differentially correlated to resident Staphylococci in lesional and non-lesional skin in atopic eczema

2017 ◽  
Vol 137 (10) ◽  
pp. S262
Author(s):  
M. Reiger ◽  
C. Altunbulakli ◽  
A.U. Neumann ◽  
N. Garzorz-Stark ◽  
M. Fleming ◽  
...  
Keyword(s):  
Atopic Eczema ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Lesional Skin

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients

2013 ◽  
Vol 23 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Jeroen van Smeden ◽  
Michelle Janssens ◽  
Edward C. J. Kaye ◽  
Peter J. Caspers ◽  
Adriana P. Lavrijsen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Chain Length ◽  
Atopic Eczema ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Fatty Acid Chain Length ◽  
Fatty Acid Chain

Lipid to protein ratio plays an important role in the skin barrier function in patients with atopic eczema

2014 ◽  
Vol 170 (6) ◽  
pp. 1248-1255 ◽  
Author(s):  
M. Janssens ◽  
J. van Smeden ◽  
G.J. Puppels ◽  
A.P.M. Lavrijsen ◽  
P.J. Caspers ◽  
...  
Keyword(s):  
Atopic Eczema ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Protein Ratio

Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

Allergy ◽  
2010 ◽  
Vol 65 (7) ◽  
pp. 911-918 ◽  
Author(s):  
J. M. Jungersted ◽  
H. Scheer ◽  
M. Mempel ◽  
H. Baurecht ◽  
L. Cifuentes ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Atopic Eczema ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Stratum Corneum Lipids

Skin barrier function in infancy: a systematic review

2014 ◽  
Vol 306 (7) ◽  
pp. 591-599 ◽  
Author(s):  
Laine Ludriksone ◽  
Natalie Garcia Bartels ◽  
Varvara Kanti ◽  
Ulrike Blume-Peytavi ◽  
Jan Kottner
Keyword(s):  
Systematic Review ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function

Skin Barrier Function Repair Is the Next Step in Atopic Dermatitis Treatment

2006 ◽  
Vol 37 (11) ◽  
pp. 19
Author(s):  
DAMIAN MCNAMARA
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function
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