Pineal Photoreceptor Cells in Culture: Fine Structure, and Light/ Dark Control of Cyclic Nucleotide Levels and Melatonin Secretion

1992 ◽  
Vol 4 (5) ◽  
pp. 641-651 ◽  
Author(s):  
Jack Falcoón ◽  
Valérie Bégay ◽  
Colette Besse ◽  
Jean-Paul Ravault ◽  
Jean-Pierre Collin
Keyword(s):  
Fine Structure ◽  
Cyclic Nucleotide ◽  
Photoreceptor Cells ◽  
Melatonin Secretion ◽  
Dark Control ◽  
Cells In Culture

Sequence of Changes in the Fine Structure of the Retina of Dogs Irradiated During Retinal Maturation

1967 ◽  
Vol 25 ◽  
pp. 166-167
Author(s):  
James N. Shively ◽  
Robert D. Phemister ◽  
Glenwood P. Epling
Keyword(s):  
Fine Structure ◽  
Ionizing Radiation ◽  
Photoreceptor Cells ◽  
Rosette Formation ◽  
Severe Dysplasia ◽  
Outer Segments ◽  
Mammalian Retina ◽  
Retinal Dysplasia

It has been known since early in this century that exposure to ionizing radiation during maturation of the mammalian retina results in necrosis of post-mitotic differentiating cells in the nuclear layer, followed by marked retinal dysplasia with rosette formation, and partial to complete agenesis of outer segments of photoreceptor cells. The effect has been morphologically related to the area of the retina undergoing differentiation at the time of irradiation. Alteration in spacial and pressure relationships are said to result in the tubular rosette formations. These effects have been described in mice, rats, monkeys, dogs and man. Doses less than 25 R have produced severe dysplasia in the developing retina of mice. The mature retina is damaged only by doses of several hundred to a few thousand R.

scholarly journals Cyclic Nucleotide-gated Channels on the Flagellum Control Ca2+ Entry into Sperm

1998 ◽  
Vol 142 (2) ◽  
pp. 473-484 ◽  
Author(s):  
Burkhard Wiesner ◽  
Jocelyn Weiner ◽  
Ralf Middendorff ◽  
Volker Hagen ◽  
U. Benjamin Kaupp ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Photoreceptor Cells ◽  
Structural Basis ◽  
Α Subunit ◽  
Cyclic Nucleotide Gated Channels ◽  
Bending Waves ◽  
Mammalian Sperm ◽  
Vertebrate Photoreceptor ◽  
Α And Β Subunits ◽  
Principal Piece

Cyclic nucleotide-gated (CNG) channels are key elements of cGMP- and cAMP-signaling pathways in vertebrate photoreceptor cells and in olfactory sensory neurons, respectively. These channels form heterooligomeric complexes composed of at least two distinct subunits (α and β). The α subunit of cone photoreceptors is also present in mammalian sperm. Here we identify one short and several long less abundant transcripts of β subunits in testis. The α and β subunits are expressed in a characteristic temporal and spatial pattern in sperm and precursor cells. In mature sperm, the α subunit is observed along the entire flagellum, whereas the short β subunit is restricted to the principal piece of the flagellum. These findings suggest that different forms of CNG channels coexist in the flagellum. Confocal microscopy in conjunction with the Ca2+ indicator Fluo-3 shows that the CNG channels serve as a Ca2+ entry pathway that responds more sensitively to cGMP than to cAMP. Assuming that CNG channel subtypes differ in their Ca2+ permeability, dissimilar localization of α and β subunits may give rise to a pattern of Ca2+ microdomains along the flagellum, thereby providing the structural basis for control of flagellar bending waves.

Cyclic nucleotide metabolism in differentiated and undifferentiated epithelial thyroid cells in culture

1981 ◽  
Vol 676 (1) ◽  
pp. 91-100 ◽  
Author(s):  
Enza Mandato ◽  
Rosalia Catapano ◽  
Francesco S. Ambesi-Impiombato ◽  
Vincenzo Macchia
Keyword(s):  
Cyclic Nucleotide ◽  
Nucleotide Metabolism ◽  
Thyroid Cells ◽  
Cells In Culture

Calcium and melatonin production in dissociated trout pineal photoreceptor cells in culture

Cell Calcium ◽  
1994 ◽  
Vol 16 (1) ◽  
pp. 37-46 ◽  
Author(s):  
V. Bégay ◽  
P. Bois ◽  
J.P. Collin ◽  
J. Lenfant ◽  
J. Falcón
Keyword(s):  
Photoreceptor Cells ◽  
Cells In Culture ◽  
Melatonin Production

Regulation of the Rhythmic Melatonin Secretion by Fish Pineal Photoreceptor Cells

1992 ◽  
pp. 167-198 ◽  
Author(s):  
Jacky Falcón ◽  
Christelle Thibault ◽  
Valerie Begay ◽  
Andreas Zachmann ◽  
Jean-Pierre Collin
Keyword(s):  
Photoreceptor Cells ◽  
Melatonin Secretion
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