The relation between serum markers in the second trimester and placental pathology. A study on extremely small for gestational age fetuses

Author(s):  
John Kingdom
Author(s):  
U. Nowacka ◽  
I. Papastefanou ◽  
A. Bouariu ◽  
A. Syngelaki ◽  
R. Akolekar ◽  
...  

2021 ◽  
pp. 109352662110251
Author(s):  
James Roberts ◽  
Jeanette D Cheng ◽  
Elizabeth Moore ◽  
Carla Ransom ◽  
Minhui Ma ◽  
...  

Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case of a 31-year-old mother with SARS-CoV-2 infection who delivered a preterm female neonate who tested negative for SAR-CoV2 infection. Placental examination demonstrated a small for gestational age placenta with extensive intervillous histiocytosis, syncytiotrophoblast karyorrhexis, and diffuse intervillous fibrin deposition. Immunohistochemical staining demonstrated infection of the syncytiotrophoblasts by SARS-CoV-2 inversely related to the presence of intervillous histiocytes and fibrin deposition. Our case demonstrates that despite extensive placental pathology, no fetal transmission of SARS-CoV-2 occurred, as well as postulates a relationship between placental infection, inflammation, and fibrin deposition.


1975 ◽  
Vol 121 (3) ◽  
pp. 351-359 ◽  
Author(s):  
Geoffrey Altshuler ◽  
Peter Russell ◽  
Rufino Ermocilla

2001 ◽  
Vol 20 (11) ◽  
pp. 1183-1188 ◽  
Author(s):  
S Degani ◽  
Z Leibovich ◽  
I Shapiro ◽  
R Gonen ◽  
G Ohel

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