Bone healing in critical-size defects treated with bioactive glass/calcium sulfate: a histologic and histometric study in rat calvaria

2007 ◽  
Vol 18 (3) ◽  
pp. 311-318 ◽  
Author(s):  
Flávia A. C. Furlaneto ◽  
Maria J. H. Nagata ◽  
Stephen E. Fucini ◽  
Tatiana M. Deliberador ◽  
Tetuo Okamoto ◽  
...  
2010 ◽  
Vol 95B (2) ◽  
pp. 269-275 ◽  
Author(s):  
Maria J. H. Nagata ◽  
Flávia A. C. Furlaneto ◽  
Antonio J. Moretti ◽  
Jerry E. Bouquot ◽  
Chul W. Ahn ◽  
...  

2012 ◽  
Vol 28 (2) ◽  
pp. 407-414 ◽  
Author(s):  
Valdir Gouveia Garcia ◽  
Juliana Mendonça da Conceição ◽  
Leandro Araújo Fernandes ◽  
Juliano Milanezi de Almeida ◽  
Maria José Hitomi Nagata ◽  
...  

2014 ◽  
Vol 40 (3) ◽  
pp. 251-258 ◽  
Author(s):  
Irit Allon ◽  
Yakir Anavi ◽  
Dror M. Allon

Objective was to describe the effect of bioactive glass putty with and without topical simvastatin on new bone formation in critical-sized defects of rat calvaria. A calvarial bone defect was created in 20 male Wistar rats and filled with bioactive glass alone (n = 10) or combined with simvastatin (n = 10). After 4 weeks, the defects were histomorphometrically evaluated for volume fraction (Vv) of woven bone, vessel density, bioglass quantity, and inflammation. Compared to the bioglass-only group, rats treated with simvastatin had greater Vv of blood vessels (3.3% ± 0.7 vs 1.6% ± 0.1, P = .0002) and new bone (2.3% ± 0.2 vs 1.8% ± 2.5, P = .003). The Vv of the bioglass remnants in the bioglass-only group was higher than in the group treated with simvastatin (2.4% ± 0.08 vs 1.7% ± 0.3, P < .0004). Chronic inflammation was noted in 1 rat from each group. Topical simvastatin seems to improve the pro-angiogenic and pro-osteogenic properties of bioglass putty in rat calvaria critical-size defects without significant inflammation.


2008 ◽  
Vol 43 (6) ◽  
pp. 723-729 ◽  
Author(s):  
M. R. Messora ◽  
M. J. H. Nagata ◽  
R. C. M. Dornelles ◽  
S. R. M. Bomfim ◽  
F. A. C. Furlaneto ◽  
...  

2008 ◽  
Vol 43 (2) ◽  
pp. 217-223 ◽  
Author(s):  
M. R. Messora ◽  
M. J. H. Nagata ◽  
R. C. Mariano ◽  
R. C. M. Dornelles ◽  
S. R. M. Bomfim ◽  
...  

Bone ◽  
2009 ◽  
Vol 45 (2) ◽  
pp. 339-345 ◽  
Author(s):  
Maria Nagata ◽  
Michel Messora ◽  
Roberta Okamoto ◽  
Natália Campos ◽  
Natália Pola ◽  
...  

2013 ◽  
Vol 25 (11) ◽  
pp. 1228-1238 ◽  
Author(s):  
Jose L. Calvo-Guirado ◽  
Maria P. Ramírez-Fernández ◽  
Rafael A. Delgado-Ruíz ◽  
Jose E. Maté-Sánchez ◽  
Pablo Velasquez ◽  
...  

2005 ◽  
Vol 16 (6) ◽  
pp. 683-691 ◽  
Author(s):  
Luiz G. N. Melo ◽  
Maria J. H. Nagata ◽  
Alvaro F. Bosco ◽  
Luciana L. G. Ribeiro ◽  
Cristiane M. Leite

2008 ◽  
Vol 19 (8) ◽  
pp. 749-754 ◽  
Author(s):  
Rodrigo Cardoso de Oliveira ◽  
Fabio Henrique Gelonese de Oliveira ◽  
Tânia Mary Cestari ◽  
Rumio Taga ◽  
José Mauro Granjeiro

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