Brain mitochondrial dysfunction and driving simulator performance in untreated obstructive sleep apnea

2021 ◽  
Author(s):  
Andrew Vakulin ◽  
Michael A. Green ◽  
Angela L. D’Rozario ◽  
David Stevens ◽  
Hannah Openshaw ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Mitochondrial Dysfunction ◽  
Driving Simulator ◽  
Obstructive Sleep

scholarly journals High-Fat Diet-Induced Mitochondrial Dysfunction Promotes Genioglossus Injury – A Potential Mechanism for Obstructive Sleep Apnea with Obesity

2021 ◽  
Vol Volume 13 ◽  
pp. 2203-2219
Author(s):  
Qingqing Chen ◽  
Xinxin Han ◽  
Meihua Chen ◽  
Bingjiao Zhao ◽  
Bingjing Sun ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Mitochondrial Dysfunction ◽  
High Fat Diet ◽  
Potential Mechanism ◽  
High Fat ◽  
Obstructive Sleep

scholarly journals Individual Variability and Predictors of Driving Simulator Impairment in Patients with Obstructive Sleep Apnea

2014 ◽  
Vol 10 (06) ◽  
pp. 647-655 ◽  
Author(s):  
Andrew Vakulin ◽  
Peter G. Catcheside ◽  
Stuart D. Baulk ◽  
Nick A. Antic ◽  
Siobhan Banks ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Driving Simulator ◽  
Individual Variability ◽  
Obstructive Sleep

Mitochondrial dysfunction underlying aggravated cellular and molecular ageing in obstructive sleep apnea patients

2021 ◽  
Author(s):  
C Almeida ◽  
L Gaspar ◽  
B Santos ◽  
A Barros-Viegas ◽  
S Carmo-Silva ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Mitochondrial Dysfunction ◽  
Obstructive Sleep

scholarly journals Can Mitochondrial Dysfunction Be a Predictive Factor for Oxidative Stress in Patients with Obstructive Sleep Apnea?

2014 ◽  
Vol 21 (9) ◽  
pp. 1285-1288 ◽  
Author(s):  
Yoo-Suk Kim ◽  
Jin Wook Kwak ◽  
Kyu Eun Lee ◽  
Hyun Sang Cho ◽  
Su Jin Lim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Mitochondrial Dysfunction ◽  
Predictive Factor ◽  
Obstructive Sleep

Assessment of ability to drive in obstructive sleep apnea patients using a driving simulator

2019 ◽  
Vol 23 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Martin Trost ◽  
Annika Machleit-Ebner ◽  
Martina Neddermann ◽  
Peter Young
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Driving Simulator ◽  
Obstructive Sleep ◽  
Ability To Drive

Quantitative sleep EEG and polysomnographic predictors of driving simulator performance in obstructive sleep apnea

2016 ◽  
Vol 127 (2) ◽  
pp. 1428-1435 ◽  
Author(s):  
Andrew Vakulin ◽  
Angela D’Rozario ◽  
Jong-Won Kim ◽  
Brooke Watson ◽  
Nathan Cross ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Driving Simulator ◽  
Sleep Eeg ◽  
Obstructive Sleep

Treating Velopharyngeal Inadequacy Using Bilateral Buccal Flap Revision Palatoplasty

2019 ◽  
Vol 4 (5) ◽  
pp. 878-892
Author(s):  
Joseph A. Napoli ◽  
Linda D. Vallino
Keyword(s):  
Systematic Review ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
A Priori ◽  
Sufficient Evidence ◽  
Obstructive Sleep ◽  
Before And After ◽  
Buccal Flap

Purpose The 2 most commonly used operations to treat velopharyngeal inadequacy (VPI) are superiorly based pharyngeal flap and sphincter pharyngoplasty, both of which may result in hyponasal speech and airway obstruction. The purpose of this article is to (a) describe the bilateral buccal flap revision palatoplasty (BBFRP) as an alternative technique to manage VPI while minimizing these risks and (b) conduct a systematic review of the evidence of BBFRP on speech and other clinical outcomes. A report comparing the speech of a child with hypernasality before and after BBFRP is presented. Method A review of databases was conducted for studies of buccal flaps to treat VPI. Using the principles of a systematic review, the articles were read, and data were abstracted for study characteristics that were developed a priori. With respect to the case report, speech and instrumental data from a child with repaired cleft lip and palate and hypernasal speech were collected and analyzed before and after surgery. Results Eight articles were included in the analysis. The results were positive, and the evidence is in favor of BBFRP in improving velopharyngeal function, while minimizing the risk of hyponasal speech and obstructive sleep apnea. Before surgery, the child's speech was characterized by moderate hypernasality, and after surgery, it was judged to be within normal limits. Conclusion Based on clinical experience and results from the systematic review, there is sufficient evidence that the buccal flap is effective in improving resonance and minimizing obstructive sleep apnea. We recommend BBFRP as another approach in selected patients to manage VPI. Supplemental Material https://doi.org/10.23641/asha.9919352

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