Flexible enzymatic activation of artificial polyketide extender units by Streptomyces cinnamonensis into the monensin biosynthetic pathway

2018 ◽  
Vol 67 (3) ◽  
pp. 226-234 ◽  
Author(s):  
D. Möller ◽  
S. Kushnir ◽  
M. Grote ◽  
A. Ismail-Ali ◽  
K.R.M. Koopmans ◽  
...  
Keyword(s):  
Biosynthetic Pathway ◽  
Streptomyces Cinnamonensis ◽  
Enzymatic Activation

New insights into heparan sulphate biosynthesis from the study of mutant mice

2002 ◽  
Vol 69 ◽  
pp. 47-57 ◽  
Author(s):  
Catherine L. R. Merry ◽  
John T. Gallagher
Keyword(s):  
Growth Factors ◽  
Biosynthetic Pathway ◽  
Heparan Sulphate ◽  
Mutant Mice ◽  
Gene Products ◽  
Multiple Gene ◽  
Adhesion Proteins ◽  
Ligand Interactions

Heparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS–ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st-/- mice.

Synergistic reductive methyltransferase GILM and its crucial role in gilvocarcin biosynthetic pathway

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
N Tibrewal ◽  
T Downey ◽  
J Rohr
Keyword(s):  
Crucial Role ◽  
Biosynthetic Pathway
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