scholarly journals Ryanodine-sensitive calcium stores involved in neurotransmitter release from sympathetic nerve terminals of the guinea-pig.

1996 ◽  
Vol 497 (3) ◽  
pp. 657-664 ◽  
Author(s):  
A B Smith ◽  
T C Cunnane
Keyword(s):  
Guinea Pig ◽  
Sympathetic Nerve ◽  
Neurotransmitter Release ◽  
Calcium Stores ◽  
Nerve Terminals

Exocytosis from Large and Small Dense Cored Vesicles in the Sympathetic Nerve Terminals of Guinea Pig and Man

1981 ◽  
Vol 39 ◽  
pp. 484-485
Author(s):  
Åsa Thureson-Klein ◽  
David J. Dzielak ◽  
Lennart Stjärne
Keyword(s):  
Chemical Composition ◽  
Guinea Pig ◽  
Sympathetic Nerve ◽  
Transmitter Release ◽  
Chromogranin A ◽  
Opioid Peptide ◽  
Morphological Evidence ◽  
Nerve Terminals ◽  
Exact Role ◽  
Release Of Noradrenaline

Large and small dense cored vesicles are present in various proportions in the noradrenergic nerve terminals of different species. These vesicles differ not only in size but in chemical composition as well. For example, only the large vesicles contain opioid peptide, a significant amount of matrix dopamine β-hydroxylase and measurable concentrations of chromogranin A. However, while much is known about the composition of isolated large and small vesicles their exact role in transmitter release is controversial. It has not been established to what extent large and small vesicles participate in exocytosis. Moreover, physiological and pharmacological experiments have indicated that there is not always a proportional co-release of noradrenaline and dopamine β-hydroxylase. The present study was performed to find morphological evidence for the hypothesis that both large and small vesicles can release transmitter but only the large vesicles release the enzyme.

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