scholarly journals Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions

2020 ◽  
Vol 48 (5) ◽  
pp. 420-426 ◽  
Author(s):  
Mingqing Chen ◽  
Shuiying Hu ◽  
Yang Li ◽  
Alice A. Gibson ◽  
Qiang Fu ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Drug Absorption

scholarly journals Role of OATP2B1 in Drug Absorption and Drug‐Drug Interactions

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Mingqing Chen ◽  
Alice Gibson ◽  
Qiang Fu ◽  
Shuiying Hu ◽  
Alex Sparreboom
Keyword(s):  
Drug Interactions ◽  
Drug Absorption

Drug Interactions with Angiotensin Receptor Blockers: Role of Human Cytochromes P450

2016 ◽  
Vol 17 (7) ◽  
pp. 681-691 ◽  
Author(s):  
Ruirui Yang ◽  
Zhiqiang Luo ◽  
Yang Liu ◽  
Mohan Sun ◽  
Ling Zheng ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Cytochromes P450 ◽  
Angiotensin Receptor Blockers ◽  
Angiotensin Receptor ◽  
Receptor Blockers

Prevalence of drug–drug interactions in sarcoma patients: key role of the pharmacist integration for toxicity risk management

2021 ◽  
Author(s):  
Audrey Bellesoeur ◽  
Ithar Gataa ◽  
Anne Jouinot ◽  
Sarah El Mershati ◽  
Anne-Catherine Piketty ◽  
...  
Keyword(s):  
Risk Management ◽  
Drug Interactions ◽  
Toxicity Risk

Role of P-glycoprotein in Statin Drug Interactions

2006 ◽  
Vol 26 (11) ◽  
pp. 1601-1607 ◽  
Author(s):  
Carol W Holtzman ◽  
Barbara S Wiggins ◽  
Sarah A Spinler
Keyword(s):  
Drug Interactions ◽  
P Glycoprotein ◽  
Statin Drug

scholarly journals Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

1997 ◽  
Vol 86 (3) ◽  
pp. 269-282 ◽  
Author(s):  
William N. Charman ◽  
Christopher J.H. Porter ◽  
Sabena Mithani ◽  
Jennifer B. Dressman
Keyword(s):  
Drug Absorption ◽  
Physiological Mechanisms

scholarly journals The Role of Drug Interactions and Monitoring in the Prevention of Tenofovir-Associated Kidney Disease

2006 ◽  
Vol 42 (11) ◽  
pp. 1657-1658 ◽  
Author(s):  
J. A. Winston ◽  
D. H. Shepp
Keyword(s):  
Kidney Disease ◽  
Drug Interactions

scholarly journals Expression of drug transporters in the human skin: comparison in different species and models and its implication for drug development

ADMET & DMPK ◽  
2017 ◽  
Vol 5 (2) ◽  
pp. 75 ◽  
Author(s):  
Hanan Osman-Ponchet ◽  
Alexandre Gaborit ◽  
Jean-Michel Linget ◽  
Claire E. Wilson
Keyword(s):  
Human Skin ◽  
Drug Absorption ◽  
Transdermal Delivery ◽  
Drug Transporters ◽  
Drug Distribution ◽  
Skin Surface ◽  
Pharmacological Intervention ◽  
Novel Targets

<p class="ADMETabstracttext">It is clear that many drug transporters (both ABCs and SLCs) are present in the human skin. Different in vitro skin models can be used to investigate the role of drug transporters in the skin despite quantitative differences in expression profile across species. P-gp was shown to have an important influence on transdermal drug absorption in the skin and to function in “absorptive” transport, carrying substrate drugs from the skin surface to the dermis. This observation might be used to modulate drug distribution inside the skin. If drugs can be retained in the epidermis compartment by inhibition of the transporters, such property of the drug would be beneficial for treatment of dermatological diseases. Therefore, it might be feasible to control transdermal delivery of drugs to specific locations in the skin, by modulating the function of the transporters in the skin. We are at the dawn of an exciting period where drug transporters might be novel targets for improvement of drug delivery to the skin and for pharmacological intervention.</p>

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