Non-quantal acetylcholine release in the mammalian neuromuscular junction: Dependence on the extracellular concentration of magnesium and calcium ions

2010 ◽  
Vol 430 (1) ◽  
pp. 8-10 ◽  
Author(s):  
A. I. Malomouzh ◽  
E. E. Nikolsky
Keyword(s):  
Neuromuscular Junction ◽  
Calcium Ions ◽  
Acetylcholine Release ◽  
Extracellular Concentration ◽  
Quantal Acetylcholine Release

The effect of calcium on acetylcholine release from motor nerve terminals

1965 ◽  
Vol 161 (985) ◽  
pp. 496-503 ◽  
Keyword(s):  
Neuromuscular Junction ◽  
Calcium Ions ◽  
Acetylcholine Release ◽  
Motor Nerve ◽  
Nerve Terminals ◽  
Transmission Process ◽  
Terminal Axon ◽  
Deficient Medium ◽  
Site Of Action ◽  
Release Of Acetylcholine

The method of external focal recording from the neuromuscular junction has been used to locate the site of action of calcium ions in the transmission process. The muscle is placed in a calcium-deficient medium (which contains magnesium as a substitute), and the effect of localized calcium application from the recording micropipette is studied. Electrophoretic application of calcium is followed within less than 1 s by increased terminal release of acetylcholine, shown by a large increase in the number of quantal components of the end-plate potential. This effect is observed even under conditions when the terminal axon spike diminishes in size during the application of calcium. It is concluded that the action of calcium is concerned directly with the release of the transmitter, and not indirectly—as is sometimes suggested—by facilitating propagation or increasing the amplitude of the terminal nerve spike.

Protein Kinase C Facilitation of Acetylcholine Release at the Rat Neuromuscular Junction

1992 ◽  
Vol 4 (9) ◽  
pp. 823-831 ◽  
Author(s):  
Egidio D'Angelo ◽  
Paola Rossi ◽  
Franco Tanzi ◽  
Vanni Taglietti
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Neuromuscular Junction ◽  
Acetylcholine Release ◽  
Kinase C
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