Quantal and non-quantal acetylcholine release at neuromuscular junctions of muscles of different types in a model of hypogravity

2013 ◽  
Vol 448 (1) ◽  
pp. 4-6 ◽  
Author(s):  
O. V. Tyapkina ◽  
A. I. Malomouzh ◽  
L. F. Nurullin ◽  
E. E. Nikolsky
Keyword(s):  
Acetylcholine Release ◽  
Neuromuscular Junctions ◽  
Different Types ◽  
Quantal Acetylcholine Release

Quantal acetylcholine release through mediatophore proteolipid

2004 ◽  
pp. 485-488
Author(s):  
A Bloc ◽  
J Falk-Vairant ◽  
M Malo ◽  
M Israël ◽  
Y Dunant
Keyword(s):  
Acetylcholine Release ◽  
Quantal Acetylcholine Release

scholarly journals Inhibition of Kv2.1 Potassium Channels by MiDCA1, A Pre-Synaptically Active PLA2-Type Toxin from Micrurus dumerilii carinicauda Coral Snake Venom

Toxins ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 335
Author(s):  
Niklas Schütter ◽  
Yuri Correia Barreto ◽  
Vitya Vardanyan ◽  
Sönke Hornig ◽  
Stephen Hyslop ◽  
...  
Keyword(s):  
Snake Venom ◽  
Potassium Current ◽  
Acetylcholine Release ◽  
Channel Blocker ◽  
Neuromuscular Junctions ◽  
Coral Snake ◽  
Drg Neurons ◽  
Kv Channels ◽  
Heterologous System ◽  
Outward Potassium Current

MiDCA1, a phospholipase A2 (PLA2) neurotoxin isolated from Micrurus dumerilii carinicauda coral snake venom, inhibited a major component of voltage-activated potassium (Kv) currents (41 ± 3% inhibition with 1 μM toxin) in mouse cultured dorsal root ganglion (DRG) neurons. In addition, the selective Kv2.1 channel blocker guangxitoxin (GxTx-1E) and MiDCA1 competitively inhibited the outward potassium current in DRG neurons. MiDCA1 (1 µM) reversibly inhibited the Kv2.1 current by 55 ± 8.9% in a Xenopus oocyte heterologous system. The toxin showed selectivity for Kv2.1 channels over all the other Kv channels tested in this study. We propose that Kv2.1 channel blockade by MiDCA1 underlies the toxin’s action on acetylcholine release at mammalian neuromuscular junctions.

Sign in / Sign up

Export Citation Format

Share Document