scholarly journals Megaloblastic Anaemia Due to Phenytoin Sodium

BMJ ◽  
1955 ◽  
Vol 2 (4933) ◽  
pp. 242-243 ◽  
Author(s):  
G. M. S. Ryan ◽  
J. W. B. Forshaw
The Lancet ◽  
1954 ◽  
Vol 264 (6844) ◽  
pp. 921 ◽  
Author(s):  
E.G. Rhind ◽  
S. Varadi

1957 ◽  
Vol 103 (432) ◽  
pp. 606-609 ◽  
Author(s):  
Robin C. Benians ◽  
Richard A. Hunter

It has now been established that megaloblastic anaemia may develop in patients receiving the anti-convulsant drugs phenytoin sodium (“Epanutin”) and primidone (“Mysoline”), given alone or in combination with phenobarbitone. Hobson et al. (1956) found 16 such cases described in the literature, and reported a case of their own in which megaloblastic anaemia developed in a patient addicted to a preparation (“Tuinal”) containing equal parts of amylobarbitone sodium (“Sodium amytal”) and quinalbarbitone sodium (“Seconal Sodium”), which are closely related chemically to primidone, sodium phenytoin and phenobarbitone. Characteristically the anaemia is not related to a deficiency of nor does it respond to treatment with vitamin B12, nor is there achlorhydria, thus distinguishing it from true Addisonian pernicious anaemia. The condition however responds promptly to the administration of folic acid by mouth.


The Lancet ◽  
1954 ◽  
Vol 264 (6846) ◽  
pp. 1017-1018 ◽  
Author(s):  
JeanM. Webster

1981 ◽  
Vol 2 (9) ◽  
pp. 454-455
Author(s):  
T. J. S. Smith ◽  
R. G. Malon

1976 ◽  
Vol 56 (1) ◽  
pp. 10-13 ◽  
Author(s):  
C. Rozman ◽  
S. Woessner

1965 ◽  
Vol 18 (3) ◽  
pp. 349-352 ◽  
Author(s):  
A. K. Singh ◽  
N. K. Shinton

BMJ ◽  
1961 ◽  
Vol 2 (5258) ◽  
pp. 998-999 ◽  
Author(s):  
A. Doig ◽  
J. B. Stanton

Sign in / Sign up

Export Citation Format

Share Document