scholarly journals An unusual case of chronic renal failure

2002 ◽  
Vol 78 (916) ◽  
pp. 103-104
Author(s):  
A L Manoj
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Unusual Case

Unusual Case of Proximal Calciphylaxis without Renal Failure

2011 ◽  
Vol 15 (5) ◽  
pp. 290-292 ◽  
Author(s):  
Monica Stanciu ◽  
Angélique Gagné-Henley ◽  
Geneviève Thérien
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Unusual Case ◽  
Sodium Thiosulfate ◽  
Exceptional Case ◽  
Tissue Necrosis ◽  
Wound Debridement ◽  
Total Body ◽  
End Stage

Background: Calciphylaxis is a rare syndrome of vascular calcification with subsequent cutaneous and tissue necrosis. It usually manifests as a complication of end-stage renal failure, affecting 1 to 4% of long-term dialysis patients. Very exceptionally, it can occur without chronic renal failure. Objective: The goal of this study was to discuss an exceptional case of extensive calciphylaxis in the absence of chronic renal failure and its successful management. Methods: We present a case of a 31-year-old woman with extensive proximal, ulcerated calciphylaxis without associated chronic renal failure. Our patient had quite a few risk factors associated with the pathogenesis of calciphylaxis, such as obesity, malnutrition, and a transient episode of acute renal failure. Results: She was successfully treated with sodium thiosulfate, extensive wound débridement (more than 30% total body surface), and subsequent skin grafts. The patient has miraculously survived this often fatal condition. Conclusion: Calciphylaxis can occur even in the absence of chronic renal failure. This often fatal condition can be managed successfully with a combination of aggressive wound control and the fairly newly described sodium thiosulfate therapy.

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