UNCERTAINTY ESTIMATES IN THE FUZZY-PRODUCT-LIMIT ESTIMATOR

Author(s):  
KIAN POKORNY ◽  
DILEEP SULE

The Fuzzy-Product-Limit Estimator (FPLE) is a method for estimating a survival curve and the mean survival time when very few data are available and a high proportion of the data are censored. Considering censored times as vague failure times, the censored values are represented by fuzzy membership functions that represent a belief of continued survival of the associated unit. Associated with any estimate is uncertainty. With the FPLE two distinct types of uncertainty exist in the estimate, the uncertainty due to the randomness in the recorded times and the vague uncertainty in the failure of the censored units. This paper addresses the problem of providing confidence bounds and estimates of uncertainty for the FPLE. Several methods for estimating the vague uncertainty in the estimator are suggested. Among them are the use of Efron's Bootstrap that obtains a confidence interval of the FPLE to quantify random uncertainty and produces an empirical distribution that is used to quantify properties of the vague uncertainty. Also, a method to obtain a graphical representation of the random and vague uncertainties is developed. The new methods provide confidence intervals that quantify statistical uncertainty as well as the vague uncertainty in the estimates. Finally, results of simulations are provided to demonstrate the efficacy of the estimator and uncertainty in the estimates.

Author(s):  
KIAN POKORNY ◽  
DILEEP SULE

In this paper, a computational system is developed that estimates a survival curve and a point estimate when very few data are available and a high proportion of the data are censored. Standard statistical methods require a more complete data set. With any less data expert knowledge or heuristic methods are required. The system uses numerical methods to define fuzzy membership functions about each data point that quantify uncertainty due to censoring. The "fuzzy" data is then used to estimate a survival curve and the mean survival time is calculated from the curve. The new estimator converges to the Product-Limit estimator when a complete data set is available. In addition, this method allows for the incorporation of expert knowledge. Finally, simulation results are provided to demonstrate the performance of the new method and its improvement over the Product-Limit estimator.


2016 ◽  
Vol 27 (2) ◽  
pp. 384-397
Author(s):  
Alan D Hutson

In this note, we develop a new and novel semi-parametric estimator of the survival curve that is comparable to the product-limit estimator under very relaxed assumptions. The estimator is based on a beta parametrization that warps the empirical distribution of the observed censored and uncensored data. The parameters are obtained using a pseudo-maximum likelihood approach adjusting the survival curve accounting for the censored observations. In the univariate setting, the new estimator tends to better extend the range of the survival estimation given a high degree of censoring. However, the key feature of this paper is that we develop a new two-group semi-parametric exact permutation test for comparing survival curves that is generally superior to the classic log-rank and Wilcoxon tests and provides the best global power across a variety of alternatives. The new test is readily extended to the k group setting.


1975 ◽  
Vol 12 (S1) ◽  
pp. 67-87 ◽  
Author(s):  
Paul Meier

The product-limit estimator for a distribution function, appropriate to observations which are variably censored, was introduced by Kaplan and Meier in 1958; it has provided a basis for study of more complex problems by Cox and by others. Its properties in the case of random censoring have been studied by Efron and later writers. The basic properties of the product-limit estimator are here shown to be closely parallel to the properties of the empirical distribution function in the general case of variably and arbitrarily censored observations.


Stat ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Amir Hossein Shabani ◽  
Hadi Jabbari ◽  
Vahid Fakoor

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