Response Adaptation of Medial Olivocochlear Neurons Is Minimal

2001 ◽  
Vol 86 (5) ◽  
pp. 2381-2392 ◽  
Author(s):  
M. C. Brown
Keyword(s):  
Firing Rate ◽  
Auditory Nerve ◽  
General Characteristic ◽  
Nerve Fibers ◽  
Short Term ◽  
Percentage Decrease ◽  
Short Term Adaptation ◽  
Auditory Nerve Fibers ◽  
Medial Olivocochlear

Response adaptation is a general characteristic of neurons. A number of studies have investigated the adaptation characteristics of auditory-nerve fibers, which send information to the brain about sound stimuli. However, there have been no previous adaptation studies of olivocochlear neurons, which provide efferent fibers to hair cells and auditory nerve dendrites in the auditory periphery. To study adaptation in efferent fibers, responses of single olivocochlear neurons were recorded to characteristic-frequency tones and noise, using anesthetized guinea pigs. To measure short-term adaptation, stimuli of 500 ms duration were presented, and the responses were displayed as peristimulus time histograms. These histograms showed regular peaks, indicating a “chopping” pattern of response. The rate during each chopping period as well as the general trend of the histogram could be well fit by an equation that expresses the firing rate as a sum of 1) a short-term adaptive rate that decays exponentially with time and 2) a constant steady-state rate. For the adaptation in medial olivocochlear (MOC) neurons, the average exponential time constant was 47 ms, which is roughly similar to that for short-term adaptation in auditory-nerve fibers. The amount of adaptation (expressed as a percentage decrease of onset firing rate), however, was substantially less in MOC neurons (average 31%) than in auditory-nerve fibers (average 63%). To test for adaptation over longer periods, we used noise and tones of 10 s duration. After the short-term adaptation, the responses of MOC neurons were almost completely sustained (average long-term adaptation 3%). However, in the same preparations, significant long-term adaptation was present in auditory-nerve fibers. These results indicate that the MOC response adaptation is minimal compared with that of auditory-nerve fibers. Such sustained responses may enable the MOC system to produce sustained effects in the periphery, supporting a role for this efferent system during ongoing stimuli of long duration.

Encoding timing and intensity in the ventral cochlear nucleus of the cat

1986 ◽  
Vol 56 (2) ◽  
pp. 261-286 ◽  
Author(s):  
W. S. Rhode ◽  
P. H. Smith
Keyword(s):  
Firing Rate ◽  
Cochlear Nucleus ◽  
Auditory Nerve ◽  
Cell Types ◽  
Nerve Fibers ◽  
Frequency Selectivity ◽  
Firing Rates ◽  
Ventral Cochlear Nucleus ◽  
Auditory Nerve Fibers ◽  
Different Cell Types

Physiological response properties of neurons in the ventral cochlear nucleus have a variety of features that are substantially different from the stereotypical auditory nerve responses that serve as the principal source of activation for these neurons. These emergent features are the result of the varying distribution of auditory nerve inputs on the soma and dendrites of the various cell types within the nucleus; the intrinsic membrane characteristics of the various cell types causing different responses to the same input in different cell types; and secondary excitatory and inhibitory inputs to different cell types. Well-isolated units were recorded with high-impedance glass microelectrodes, both intracellularly and extracellularly. Units were characterized by their temporal response to short tones, rate vs. intensity relation, and response areas. The principal response patterns were onset, chopper, and primary-like. Onset units are characterized by a well-timed first spike in response to tones at the characteristic frequency. For frequencies less than 1 kHz, onset units can entrain to the stimulus frequency with greater precision than their auditory nerve inputs. This implies that onset units receive converging inputs from a number of auditory nerve fibers. Onset units are divided into three subcategories, OC, OL, and OI. OC units have extraordinarily wide dynamic ranges and low-frequency selectivity. Some are capable of sustaining firing rates of 800 spikes/s at high intensities. They have the smallest standard deviation and coefficient of variation of the first spike latency of any cells in the cochlear nuclei. OC units are candidates for encoding intensity. OI and OL units differ from OC units in that they have dynamic ranges and frequency selectivity ranges much like those of auditory nerve fibers. They differ from one another in their steady-state firing rates; OI units fire mainly at the onset of a tone. OI units also differ from OL units in that they prefer frequency sweeps in the low to high direction. Primary-like-with-notch (PLN) units also respond to tones with a well-timed first spike. They differ from onset cells in that the onset peak is not always as precise as the spontaneous rate is higher. A comparison of spontaneous firing rate and saturation firing rate of PLN units with auditory nerve fibers suggest that PLN units receive one to four auditory nerve fiber inputs. Chopper units fire in a sustained regular manner when they are excited by sound.(ABSTRACT TRUNCATED AT 400 WORDS)

Envelope Coding in the Lateral Superior Olive. III. Comparison With Afferent Pathways

1998 ◽  
Vol 79 (1) ◽  
pp. 253-269 ◽  
Author(s):  
Philip X. Joris ◽  
Tom C. T. Yin
Keyword(s):  
Firing Rate ◽  
Auditory Nerve ◽  
Modulation Frequency ◽  
Nerve Fibers ◽  
Cell Populations ◽  
Average Firing Rate ◽  
Afferent Pathways ◽  
Lateral Superior Olive ◽  
Superior Olive ◽  
Auditory Nerve Fibers

Joris, Philip X. and Tom C. T. Yin. Envelope coding in the lateral superior olive. III. Comparison with afferent pathways. J. Neurophysiol. 79: 253–269, 1998. Binaural cues for spatial localization of complex high-frequency sounds are interaural level and time differences (ILDs and ITDs). We previously showed that cells in the lateral superior olive (LSO) are sensitive to ITDs in the envelope of sinusoidally amplitude-modulated (AM) signals up to a modulation frequency of only ∼800 Hz. To understand the limitations in this ITD-sensitivity, we here compare responses to monaural modulation in LSO and its input pathways, derived from cochlear nucleus and medial nucleus of the trapezoid body. These pathways have marked functional and morphological specializations, suggestive of adaptations for timing. Afferent cell populations were identified on the basis of electrophysiological signatures, and for each population, average firing rate and synchronization to AM tones were compared with auditory-nerve fibers and LSO cells. Except for an increase in modulation gain in some subpopulations, synchronization of LSO afferents was very similar to that in auditory nerve fibers in its dependency on sound pressure level (SPL), modulation depth, and modulation frequency. Distributions of cutoff frequencies of modulation transfer functions were largely coextensive with the distribution in auditory nerve. Group delays, measured from the phase of the response modulation as a function of modulation frequency, showed an orderly dependence on characteristic frequency and cell type and little dependence on SPL. Similar responses were obtained to a modulated broadband carrier. Compared with their afferents, LSO cells synchronized to monaurally modulated stimuli with a higher gain but often over a narrower range of modulation frequencies. Considering the scatter in afferent and LSO cell populations, ipsi- and contralateral responses were well matched in cutoff frequency and magnitude of delays. In contrast to their afferents, LSO cells show a decrease in average firing rate at high modulation frequencies. We conclude that the restricted modulation frequency range over which LSO cells show ITD-sensitivity does not result from loss of envelope information along the afferent pathway but is due to convergence or postsynaptic effects at the level of the LSO. The faithful transmission of envelope phase-locking in LSO afferents is consistent with their physiological and morphological adaptations, but these adaptations are not commensurate with the rather small effects of physiological ITDs reported previously, especially when compared with effects of ILDs. We suggest that these adaptations have evolved to allow a comparison of instantaneous amplitude fluctuations at the two ears rather than to extract interaural timing information per se.

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