scholarly journals Optical Coherence Tomography Imaging of Choroidal Abnormalities in Neurofibromatosis Type 1

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Shinji Makino ◽  
Hironobu Tampo
Keyword(s):  
Optical Coherence Tomography ◽  
Neurofibromatosis Type 1 ◽  
Fundus Autofluorescence ◽  
Neurofibromatosis Type ◽  
Posterior Pole ◽  
Optical Coherence ◽  
Tomography Imaging ◽  
Optical Coherence Tomography Imaging

We report a case of neurofibromatosis type 1 (NF1) examined by infrared fundus autofluorescence (IR-FAF) and optical coherence tomography (OCT) to characterize the associated choroidal abnormalities. The conventional ophthalmoscopic findings were unremarkable. However, IR-FAF revealed multiple bright patchy lesions in the choroid of the posterior pole, in both eyes. OCT demonstrated irregular hyperreflectivity at the sites of these lesions. Patients with NF1 may have typical choroidal lesions that are visible on IR-FAF, which can be confirmed through OCT.

Optical coherence tomography angiography of choroidal nodules in neurofibromatosis type-1: A case series

2021 ◽  
pp. 112067212110307
Author(s):  
Francisco Javier Moreno-Morillo ◽  
José Ignacio Fernández-Vigo ◽  
Bárbara Burgos-Blasco ◽  
Carlos Llorente-La Orden ◽  
Beatriz Vidal-Villegas ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Neurofibromatosis Type 1 ◽  
Optical Coherence Tomography Angiography ◽  
Case Series ◽  
Neurofibromatosis Type ◽  
Vessel Density ◽  
Enhanced Depth Imaging ◽  
Optical Coherence ◽  
Near Infrared Reflectance

Purpose: To describe optical coherence tomography angiography (OCTA) findings in the retina and choroid of patients with neurofibromatosis type 1 (NF1). Methods: We describe a series of four patients diagnosed with NF1 and choroidal nodules who underwent a comprehensive ophthalmic evaluation including a retinal multimodal imaging study based on retinography, near-infrared reflectance imaging (NIR), enhanced depth imaging (EDI) optical coherence tomography (OCT) and OCTA. Results: Patients were three women and one man aged 36–47 years. In all patients, the choroidal nodules were not visible in retinographies but easily detectable with NIR, appearing as multiple bright patches. On OCTA, we observed reduced vessel density in the choriocapillaris in zones where choroidal nodules appeared in OCT images. In one patient, a corkscrew vessel was visible in the superficial capillary plexus. Conclusion: Choriocapillaris vessel density was reduced in zones where choroidal nodules occur in NF1 patients. Further work is needed to clarify the clinical relevance of this finding.

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