F-18 FDG-PET-CT in the Diagnostic of a Late Medullary Thyroid Carcinoma Recurrence in a Patient with Follicular-Papillary Thyroid Cancer

Mixed medullary and follicular or papillary carcinoma of thyroid is an extremely rare tumor, characterized by coexistence of morphological and immunohistochemical features of both medullary carcinoma and follicular (or papillary) carcinoma. This case report describes for the first time in the indexed database a late recurrence of a medullary thyroid carcinoma initially diagnosed as follicular-papillary form, treated and monitored accordingly. After 14 years, a superior mediastinum tumor was discovered incidentally at a thorax computer tomography. The whole-body I-131 scan was negative and F-18 FDG-PET-CT showed glucose avidity of the tumor. The patient was operated on and the histology revealed medullary thyroid carcinoma. If there are no possibilities to have routinely extensive immunohistologic profiles, it is recommended to check the serum calcitonin, at least in any patient with confirmed thyroid carcinoma.

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Localization of Medullary Thyroid Carcinoma after Surgery Using11C-Methionine PET/CT: Comparison with18F-FDG PET/CT.

10.1210/endo-meetings.2010.part1.p12.p1-577 ◽

2010 ◽

pp. P1-577-P1-577

Author(s):

Hye Won Jang ◽

Ji In Lee ◽

Hee Kyung Kim ◽

Seo Young Sohn ◽

Sun Wook Kim ◽

...

Keyword(s):

Thyroid Carcinoma ◽

Medullary Thyroid Carcinoma ◽

Fdg Pet ◽

Medullary Thyroid ◽

Pet Ct ◽

Fdg Pet Ct

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Comparison of 68Ga-DOTATATE PET-CT, 18F-FDG PET-CT and 99mTc-(V)DMSA scintigraphy in the detection of recurrent or metastatic medullary thyroid carcinoma

Nuclear Medicine Communications ◽

10.1097/mnm.0000000000000240 ◽

2015 ◽

Vol 36 (3) ◽

pp. 242-250 ◽

Cited By ~ 21

Author(s):

Zeynep G. Ozkan ◽

Serkan Kuyumcu ◽

Ayse Kubat Uzum ◽

Mehmet F. Gecer ◽

Sevda Ozel ◽

...

Keyword(s):

Thyroid Carcinoma ◽

Medullary Thyroid Carcinoma ◽

Fdg Pet ◽

Medullary Thyroid ◽

Dmsa Scintigraphy ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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The value of 18F-DOPA PET-CT in patients with medullary thyroid carcinoma: comparison with 18F-FDG PET-CT

European Radiology ◽

10.1007/s00330-008-1280-7 ◽

2009 ◽

Vol 19 (6) ◽

pp. 1425-1434 ◽

Cited By ~ 85

Author(s):

Mohsen Beheshti ◽

Sigrid Pöcher ◽

Reza Vali ◽

Peter Waldenberger ◽

Gabriele Broinger ◽

...

Keyword(s):

Thyroid Carcinoma ◽

Medullary Thyroid Carcinoma ◽

Fdg Pet ◽

Medullary Thyroid ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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The role of 18F-FDG PET/CT in detecting metastatic deposits of recurrent medullary thyroid carcinoma: A prospective study

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2007.08.005 ◽

2008 ◽

Vol 34 (5) ◽

pp. 581-586 ◽

Cited By ~ 47

Author(s):

D. Rubello ◽

L. Rampin ◽

C. Nanni ◽

E. Banti ◽

M. Ferdeghini ◽

...

Keyword(s):

Thyroid Carcinoma ◽

Prospective Study ◽

Medullary Thyroid Carcinoma ◽

Fdg Pet ◽

Medullary Thyroid ◽

Pet Ct ◽

18F Fdg ◽

A Prospective Study ◽

Fdg Pet Ct

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Carcinoembryonic Antigen Increase in a Patient with Colon Cancer Who Have Achieved Complete Remission and Negative 18F-FDG PET/CT: Don’t Forget the Thyroid!

Current Oncology ◽

10.3390/curroncol28040261 ◽

2021 ◽

Vol 28 (4) ◽

pp. 2987-2992

Author(s):

Alexandre Lugat ◽

Pauline Hulo ◽

Catherine Ansquer ◽

Yann Touchefeu ◽

Eric Mirallié ◽

...

Keyword(s):

Thyroid Carcinoma ◽

Carcinoembryonic Antigen ◽

Medullary Thyroid Carcinoma ◽

Fdg Pet ◽

Colon Adenocarcinoma ◽

Medullary Thyroid ◽

Pet Ct ◽

Serum Carcinoembryonic Antigen ◽

18F Fdg ◽

Fdg Pet Ct

Serum carcinoembryonic antigen (CEA) is a tumor marker especially used to follow a patient with colorectal cancer. However, it is non-specific and could be increased in several cancers and some benign conditions. We report the case of a 70-year-old man followed since 2014 for a left colon adenocarcinoma with the persistence of an increased CEA. There was no evidence of recurrence, but a right lobar thyroid nodule without a significantly increased uptake was incidentally discovered on the CT scan of 18F-fluorodeoxyglucose (18F-FDG) PET/CT. We suspected a medullary thyroid carcinoma (MTC) explaining the persistent elevation of CEA. Plasma calcitonin levels were 47 ng/L (N < 10). Fine needle aspiration cytology found atypia of undetermined significance and the patient was reluctant to undergo surgery without any further exploration. We performed a 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET/CT preoperatively which revealed a punctiform focus of the right thyroid lobe corresponding to a pT1aN1aMxR0 medullary thyroid carcinoma, histopathologically confirmed. This case highlights that despite the potential usefulness of 18F-FDG PET/CT in case of an unknown source of elevated CEA this imaging may be falsely negative as in the case of MTC and should lead to further explorations.

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