A Rare Cause of Prepubertal Gynecomastia: Sertoli Cell Tumor

Prepubertal gynecomastia due to testis tumors is a very rare condition. Nearly 5% of the patients with testicular mass present with gynecomastia. Sertoli cell tumors are sporadic in 60% of the reported cases, while the remaining is a component of multiple neoplasia syndromes such as Peutz-Jeghers syndrome and Carney complex. We present a 4-year-old boy with gynecomastia due to Sertoli cell tumor with no evidence of Peutz-Jeghers syndrome or Carney complex.

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Isolated Large Cell Calcifying Sertoli Cell Tumor in a Young Boy, not Associated with Peutz-Jeghers Syndrome or Carney Complex

Annals of Clinical and Laboratory Research ◽

10.21767/2386-5180.10002 ◽

2015 ◽

Vol 3 (1) ◽

Cited By ~ 1

Author(s):

Jin Ping Lai ◽

Chyi chia Lee

Keyword(s):

Sertoli Cell ◽

Large Cell ◽

Carney Complex ◽

Cell Tumor ◽

Sertoli Cell Tumor ◽

Peutz Jeghers Syndrome

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Sertoli Cell Tumor Causing Precocious Puberty in a Girl with Peutz-Jeghers Syndrome

Gynecologic Oncology ◽

10.1006/gyno.1998.5063 ◽

1998 ◽

Vol 70 (3) ◽

pp. 421-424 ◽

Cited By ~ 25

Author(s):

Amnon Zung ◽

Zeev Shoham ◽

Magda Open ◽

Yehudit Altman ◽

Ram Dgani ◽

...

Keyword(s):

Sertoli Cell ◽

Precocious Puberty ◽

Cell Tumor ◽

Sertoli Cell Tumor ◽

Peutz Jeghers Syndrome

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Case Report on Sertoli Cell Tumor of Ovary

Bangladesh Journal of Obstetrics & Gynaecology ◽

10.3329/bjog.v31i1.34278 ◽

2017 ◽

Vol 31 (1) ◽

pp. 54-56

Author(s):

Kohinoor Begum ◽

Kamil Ara Khanom ◽

Joysree Saha

Keyword(s):

Sertoli Cell ◽

Leydig Cells ◽

Histopathological Examination ◽

Cell Tumor ◽

Solid Mass ◽

Sertoli Cell Tumor ◽

Hormonal Function ◽

History Of ◽

Well Differentiated ◽

Sertoli Cell Tumors

A 33 years old lady presented with history of irregular menstrual cycle followed by menorrhagia. USG revealed left ovarian solid mass but all tumor markers were within normal range. A solid mass on left sided ovary was found on laparotomy. Histopathological examination of the mass showed well differentiated sertoli cell tumor. Tumors of the stroma (Leydig cells) and/or sex cords (Sertoli cells) represent approximately 8% of ovarian tumors and develop from the connective tissue (respectively, interstitial and nurse cells) of the ovary. Because these cells participate in ovarian hormonal function, most of the sex-cord or stromal tumors are able to secrete hormones (estrogens, androgens, corticoids), which explains the hormonal dysfunctions associated with these tumors. Their prognosis are difficult to establish; some of the tumors are almost always benign (Sertoli cell tumors, Leydig cell tumors), whereas others are malignant but with more-or-less delayed local-regional or metastatic relapses.Bangladesh J Obstet Gynaecol, 2016; Vol. 31(1) : 54-56

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Oxyphilic Sertoli Cell Tumor of the Ovary: A Report of Three Cases, Two in Patients with the Peutz-Jeghers Syndrome

International Journal of Gynecological Pathology ◽

10.1097/00004347-199407000-00010 ◽

1994 ◽

Vol 13 (3) ◽

pp. 259-266 ◽

Cited By ~ 32

Author(s):

Judith A. Ferry ◽

Robert H. Young ◽

George Engel ◽

Robert E. Scully

Keyword(s):

Sertoli Cell ◽

Cell Tumor ◽

Sertoli Cell Tumor ◽

Peutz Jeghers Syndrome

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Large Cell Calcifying Sertoli Cell Tumor with Macrocalcification in a Partially Resected Testis

Case Reports in Pathology ◽

10.1155/2020/5279013 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Mahmoud Bardisi ◽

Mohamad Nidal Khabaz ◽

Jaudah Ahmad Al-Maghrabi

Keyword(s):

Sertoli Cell ◽

Large Cell ◽

Cell Tumor ◽

Sertoli Cell Tumor ◽

Left Testis ◽

Palpable Mass ◽

Grade 3 ◽

The Right ◽

Radiological Studies ◽

Sertoli Cell Tumors

Large cell calcifying Sertoli cell tumors (LCCSCTs) are extremely rare, with less than 100 tumors being described to date. Most of the tumors are benign with a few malignant cases, and aggressive behavior is infrequent. These tumors are a type of Sertoli cell tumor, and these tumors comprise less than 0.3% of all testis tumors in Saudi Arabia. They usually occur in boys and young adults and can affect one or both testicles in multifocal form causing microcalcifications. A 28-year-old male visited our hospital with left testis pain. Physical examination of the scrotum revealed that both testicles were normal sized with no palpable mass. Ultrasonography evaluation revealed grade 3 left varicocele and an incidental 9 mm calcified mass in the right testicle, which was further confirmed by MRI. Partial orchiectomy was performed. Clinical data, radiological studies, and morphological and immunohistochemical characteristics were analyzed.

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