Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration

We present a case of 16-year-old male, who was referred from private centre for dyspnoea, fatigue, and orthopnea. The chest radiograph revealed complete opacification of left chest which was confirmed by computed tomography as a large left mediastinal mass measuring 14 × 15 × 18 cm. The diagnostic needle core biopsy revealed mixed germ cell tumour with possible combination of embryonal carcinoma, yolk sac, and teratoma. After 4 cycles of neoadjuvant BEP regime, there was initial response of tumour markers but not tumour bulk. Instead of classic median sternotomy or clamshell incision, posterolateral approach with piecemeal manner was chosen. Histology confirmed mixed germ cell tumour with residual teratomatous component without yolk sac or embryonal carcinoma component. Weighing 3.5 kg, it is one of the largest mediastinal germ cell tumours ever reported. We describe this rare and gigantic intrathoracic tumour and discuss the spectrum of surgical approach and treatment of this exceptional tumour.

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Cytological diagnosis of primary pineal germ cell tumour with a yolk sac component in cerebrospinal fluid

Cytopathology ◽

10.1111/cyt.12792 ◽

2020 ◽

Vol 31 (2) ◽

pp. 153-157

Author(s):

Alexandra Kalogeraki ◽

Dimitrios Tamiolakis ◽

Nikolaos Katzilakis ◽

Iordanis Pelagiadis ◽

Maria Raissaki ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Germ Cell ◽

Germ Cell Tumour ◽

Yolk Sac ◽

Cell Tumour ◽

Cytological Diagnosis

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Metastatic Mixed Germ Cell Tumour with Embryonal Carcinoma and Choriocarcinoma in a Female Eurasian Harvest Mouse (Micromys minutus)

Journal of Comparative Pathology ◽

10.1016/j.jcpa.2020.09.007 ◽

2020 ◽

Vol 180 ◽

pp. 122-127

Author(s):

Lucia Minoli ◽

Charles A Assenmacher ◽

Brona N Ranieri ◽

James C Tarrant ◽

Molly E Church ◽

...

Keyword(s):

Germ Cell ◽

Embryonal Carcinoma ◽

Germ Cell Tumour ◽

Cell Tumour ◽

Harvest Mouse ◽

Micromys Minutus

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Mixed Germ Cell Tumour of the Mediastinum (Seminoma, Embryonal Carcinoma, Choriocarcinoma and Teratoma)

Pathology - Research and Practice ◽

10.1016/s0344-0338(89)80076-7 ◽

1989 ◽

Vol 185 (4) ◽

pp. 506-510 ◽

Cited By ~ 5

Author(s):

G.L. Taccagni ◽

A. Parafioriti ◽

G. Dell'Antonio ◽

G. Crespi

Keyword(s):

Germ Cell ◽

Embryonal Carcinoma ◽

Germ Cell Tumour ◽

Cell Tumour

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A unique case of a sarcoma arising in a testicular non-seminomatous mixed germ cell tumour with a predominant yolk sac component

Canadian Urological Association Journal ◽

10.5489/cuaj.10069 ◽

2011 ◽

Vol 5 (5) ◽

pp. E81-E83

Author(s):

Luke T. Lavallée ◽

Nicolas LD Roustan Delatour ◽

Ilias Cagiannos ◽

Eric C Bélanger ◽

Kien T. Mai

Keyword(s):

Germ Cell ◽

Germ Cell Tumour ◽

Yolk Sac ◽

Cell Tumour ◽

Unique Case

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RARE CASES OF MIXED GERM CELL TUMOUR OF TESTIS- A REPORT OF TWO CASES WITH UNCOMMON COMBINATIONS AND REVIEW OF LITERATURE.

10.36106/paripex/8001581 ◽

2021 ◽

pp. 41-42

Author(s):

Anshu Jamaiyar ◽

Joyeeta Mandal ◽

Anupriya Anupriya

Keyword(s):

Germ Cell ◽

Embryonal Carcinoma ◽

Germ Cell Tumour ◽

Immature Teratoma ◽

Cell Tumour ◽

Germ Cell Tumours ◽

Review Of Literature ◽

Different Types ◽

Yolk Sac Tumour ◽

Rare Category

Mixed germ cell tumours of testis represent a comparatively rare category of testicular tumour where different types of both seminomatous and non-seminomatous tumours can be present in varied proportions. We report two cases of mixed germ cell tumours, one consisting of seminoma, embryonal carcinoma and post-pubertal teratoma in the testis of a 22-year-old male and second consisting of a yolk sac tumour and immature teratoma in the testis of a 19-year-old male. We report theses case due to the rare combination and for documentation

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POTPOURRI TESTICULAR TUMOUR- A RARE COMBINATION OF TESTICULAR SEMINOMATOUS MIXED GERM CELL TUMOUR WITH IMMATURE TERATOMA AND YOLK SAC TUMOUR IN A YOUNG ADULT MALE– A CASE REPORT

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2017/1047 ◽

2017 ◽

Vol 6 (67) ◽

pp. 4826-4828

Author(s):

Probhas Kumar Sarkar ◽

Partha Sarathi Mandal ◽

Kumar Dheeraj ◽

Saurabh Das ◽

Arindam Das

Keyword(s):

Case Report ◽

Young Adult ◽

Germ Cell ◽

Adult Male ◽

Germ Cell Tumour ◽

Yolk Sac ◽

Immature Teratoma ◽

Cell Tumour ◽

Testicular Tumour ◽

Yolk Sac Tumour

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A unique case of a sarcoma arising in a testicular non-seminomatous mixed germ cell tumour with a predominant yolk sac component

Canadian Urological Association Journal ◽

10.5489/cuaj.703 ◽

2013 ◽

Vol 5 (5) ◽

pp. 81

Author(s):

Luke T. Lavallée ◽

Nicolas LD Roustan Delatour ◽

Ilias Cagiannos ◽

Eric C. Bélanger ◽

Kien T. Mai

Keyword(s):

Germ Cell ◽

Germ Cell Tumour ◽

Treatment Strategies ◽

Yolk Sac ◽

Cell Tumour ◽

Unique Case ◽

Prior Chemotherapy ◽

First Case

We present a unique case of a sarcoma arising in a testicularnon-seminomatous mixed germ cell tumour with a predominantyolk sac tumour (YST) component. This is the first case reported inwhich a sarcoma is linked to YST of the testis in a patient not havingundergone prior chemotherapy. This finding confirms the ability ofYST to contain sarcoma; it underlies its importance for urologists,oncologists and pathologists to be aware of this phenomenon andto modify treatment strategies appropriately.

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