Antithrombin III (AT III) has been investigated in women before tatting the pill and after 3 months Or more, between the 22nd and the 26th day of the menstrual Cycle. The oral contraceptives consistedinacombination of a progestogen with 30 to 50 ug of oestrogen, or in a progestogen - only pill.AT III was measured by the Hancini method in plasma an serum and the antithrombin activity in serum by the von Kaulla method.The results were obtained from 120 women before taking the pill, 189 taking an oestro-progestagen : containing 50 μg oestrogenin 96 cases, 30 μg in 65 cases, 30 to 40 μg according to the day of the cycle in 28 cases, and 20 women taking a progestagen-only pill.The results show a statistically significant decrease in AT III in plasma and serum, and in antithrombin activity with all the oestroprogestagens. No difference is found between 50 and 30 fig oestrogen content. With the progestogen-only pills, no decrease in AT III is observed.