Abstract 857: MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel During Cardiac Stress to Limit Mitochondrial Calcium Overload

Cardiac Stress ◽

MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress

Circulation ◽

10.1161/circulationaha.118.037968 ◽

2019 ◽

Vol 140 (21) ◽

pp. 1720-1733 ◽

Cited By ~ 25

Author(s):

Jonathan P. Lambert ◽

Timothy S. Luongo ◽

Dhanendra Tomar ◽

Pooja Jadiya ◽

Erhe Gao ◽

...

Keyword(s):

Calcium Overload ◽

Molecular Composition ◽

Mitochondrial Calcium ◽

The Mitochondrial Calcium Uniporter: Molecular Composition and Physiological Role

Biophysical Journal ◽

10.1016/j.bpj.2014.11.1045 ◽

2015 ◽

Vol 108 (2) ◽

pp. 189a

Author(s):

Rosario Rizzuto

Keyword(s):

Physiological Role ◽

Molecular Composition ◽

Mitochondrial Calcium ◽

Abstract 539: MCUB Regulates the Macromolecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Ischemic Cardiac Injury

Circulation Research ◽

10.1161/res.123.suppl_1.539 ◽

2018 ◽

Vol 123 (Suppl_1) ◽

Author(s):

Jonathan P Lambert ◽

Timothy S Luongo ◽

Pooja Jadiya ◽

Erhe Gao ◽

Anna M Lucchesee ◽

...

Keyword(s):

Cardiac Injury ◽

Calcium Overload ◽

Mitochondrial Calcium ◽

Calcium Uniporter ◽

Macromolecular Composition

288-LB: Effects of the Hepatic Mitochondrial Calcium Uniporter on Hepatic Gluconeogenesis and Mitochondrial Metabolism in Awake Mice

Diabetes ◽

10.2337/db19-288-lb ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 288-LB

Author(s):

JI EUN LEE ◽

LEIGH GOEDEKE ◽

YE ZHANG ◽

RACHEL J. PERRY ◽

RUSSELL GOODMAN ◽

...

Keyword(s):

Mitochondrial Metabolism ◽

Mitochondrial Calcium ◽

Hepatic Gluconeogenesis ◽

Faculty Opinions recommendation of A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11446956.14779099 ◽

2011 ◽

Author(s):

Gerald Zamponi

Keyword(s):

Mitochondrial Calcium ◽

Inner Membrane ◽

Faculty Opinions recommendation of Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11546956.14463054 ◽

2011 ◽

Author(s):

Hugo Bellen ◽

Manish Jaiswal

Keyword(s):

Mitochondrial Calcium ◽

Integrative Genomics ◽

Essential Component ◽

Faculty Opinions recommendation of Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11546956.12612054 ◽

2011 ◽

Author(s):

Eduardo Rial

Keyword(s):

Mitochondrial Calcium ◽

Integrative Genomics ◽

Essential Component ◽

Faculty Opinions recommendation of Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11546956.12595054 ◽

2011 ◽

Author(s):

Markus Hoth ◽

Ivan Bogeski

Keyword(s):

Mitochondrial Calcium ◽

Integrative Genomics ◽

Essential Component ◽

Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter

Chemical Communications ◽

10.1039/d1cc01623g ◽

2021 ◽

Author(s):

Joshua J. Woods ◽

Madison X. Rodriguez ◽

Chen-Wei Tsai ◽

Ming-Feng Tsai ◽

Justin J. Wilson

Keyword(s):

Mechanisms Of Action ◽

Mitochondrial Calcium ◽

Amine Complexes ◽

The MCU-inhibitory properties and mechanisms of action of Co3+ amine complexes and Ru265 are described.

Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter

Cell Reports ◽

10.1016/j.celrep.2021.109275 ◽

2021 ◽

Vol 35 (12) ◽

pp. 109275

Author(s):

Agnese De Mario ◽

Anna Tosatto ◽

Julia Marie Hill ◽

Janos Kriston-Vizi ◽

Robin Ketteler ◽

...

Keyword(s):

Mitochondrial Calcium ◽

Functional Validation ◽