Recurrent abdominal pain occurs in 10–15% of school-aged children and is a frequent presenting complaint in general practice and general paediatric and paediatric gastroenterology clinics. Patients often have vague symptoms and investigation usually results in a low yield of organic disease. Treatment strategies are varied and often subjective with limited evidence upon which to base them. This chapter includes a general overview, classification, discussion of the complex and multifactorial aetiology, therapeutic approach, and outcome. It discusses a recommended clinical approach for the management of complex cases.