Critical Role Of CCL2 (MCP-1) In The Development Of Pulmonary Graft-Versus-Host Disease After Murine Allogeneic Bone Marrow Transplant

2012 ◽  
Author(s):  
Tereza Martinu ◽  
Julia L. Nugent ◽  
Kymberly Gowdy ◽  
Jesse Sun ◽  
Matthew A. Lyes ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Graft Versus Host Disease ◽  
Critical Role ◽  
Marrow Transplant ◽  
Allogeneic Bone ◽  
Host Disease ◽  
Graft Versus Host ◽  
Allogeneic Bone Marrow Transplant

Tacrolimus: An Alternative for Graft-Versus-Host Disease Prevention

2000 ◽  
Vol 34 (3) ◽  
pp. 377-381 ◽  
Author(s):  
Traci J Lee ◽  
LeAnne D Kennedy
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Graft Versus Host Disease ◽  
Marrow Transplant ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone ◽  
Key Words Tacrolimus ◽  
Host Disease ◽  
Graft Versus Host ◽  
Allogeneic Bone Marrow Transplant

OBJECTIVE: To evaluate the efficacy of tacrolimus for prevention of graft-versus-host disease (GVHD) in patients receiving allogeneic bone marrow transplants. DATA SOURCES: Published literature was identified through MEDLINE (January 1990–December 1998) using the key words tacrolimus, FK506, graft-versus-host disease, and bone marrow transplant. DATA SYNTHESIS: GVHD associated with allogeneic bone marrow transplant is a serious life-threatening complication. An evaluation of studies using tacrolimus for prevention of GVHD was conducted. CONCLUSIONS: Tacrolimus is effective for the prevention of GVHD in allogeneic bone marrow transplant. Further studies need to be conducted to optimize the dosage schedule and to determine therapeutic ranges, efficacy, and safety.

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