Membranous ruptures in Meniere's disease: Existence, location, and incidence

1983 ◽  
Vol 91 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Herve J. Koskas ◽  
Fred H. Linthicum ◽  
William F. House
Keyword(s):  
Light Microscopy ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Membranous Labyrinth ◽  
Ménière's Disease ◽  
Reissner’S Membrane ◽  
Temporal Bones

Whether or not attacks of Meniere's disease are related to ruptures in the membranous labyrinth is still a point of contention. To help clarify this point, we used light microscopy to study the membranous labyrinth in 14 temporal bones with hydrops from patients with Meniere's disease, four bones with hydrops from patients without Meniere's disease, and 11 normal bones. Findings suggest that ruptures are specific to bones with hydrops from patients with Meniere's disease and that they occur more frequently in Reissner's membrane than in the vestibular membranes.

Meniére's Disease and Endolymphatic Hydrops Clinical-Histopathological Correlations

1980 ◽  
Vol 89 (6_suppl2) ◽  
pp. 2-22 ◽  
Author(s):  
Bernard G. Fraysse ◽  
Antonio Alonso ◽  
William F. House
Keyword(s):  
Histopathological Examination ◽  
Endolymphatic Hydrops ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Histopathological Findings ◽  
Ménière's Disease ◽  
Temporal Bones

The clinical-histopathological correlation between Menière's disease and endolymphatic hydrops was done to explain, as much as possible, causes of symptoms of Menière's disease. Twenty-three temporal bones with endolymphatic hydrops from 17 patients were reviewed and clinical and histopathological findings were correlated. Histopathological examination revealed frequent, severe deformities in the labyrinthine walls and permanent changes in Reissner's membranes. Evidence of rupture was difficult to assess. Of 21 ears of patients with the clinical diagnosis of Menière's disease, 93% had endolymphatic hydrops. A statistical correlation between increased area of the cochlear duct and hearing loss was found. Some correlation was also found between frequency of vertigo and results of electronystagmography with histopathological findings. Consequently, the mechanical effect of endolymphatic hydrops seems to have greater significance in the production of symptoms of Menière's disease than the biochemical effect of ruptures. In a review of ten unusual cases from this series of 17 patients, traumatic neuromas or remnants of vestibular structures were found after an incomplete labyrinthectomy. Histopathological findings of four patients who had undergone endolymphatic subarachnoid shunt surgery are described.

Electron Microscopic Cochlear Observations in Bilateral Ménière's Disease

1976 ◽  
Vol 85 (6) ◽  
pp. 791-801 ◽  
Author(s):  
Robert S. Kimura ◽  
Carol Y. Ota ◽  
Harold F. Schuknecht ◽  
Tadahiko Takahashi
Keyword(s):  
Hair Cells ◽  
Meniere’S Disease ◽  
Outer Hair Cells ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Electron Microscopic ◽  
Ménière's Disease ◽  
Reissner’S Membrane

Electron microscopic study of the cochleas of an individual with bilateral Ménière's disease revealed the presence of many abnormal sensory cells in the apical regions of the cochleas. The pathological alterations were greater in the left ear with the greater hearing loss. There were some giant cilia, fusion of cilia, and loss of cilia. The outer hair cells contained diffuse cuticular bodies near or basal to the nuclei. Many outer hair cells were retracted away from the reticular membrane. The population of the nerve endings appeared normal. The inner hair cells of the apical turns appeared essentially normal. The spiral ganglia were normal in number and morphology at the apical turns, and a majority of their cell bodies were of the unmyelinated or partly myelinated types. The stria vascularis showed atrophy; however, the magnitude of this change was consistent with that known to occur in the aging ear. In the distended areas Reissner's membrane showed areas devoid of mesothelial cells, as well as atrophic epithelial cells. The blood vessels were no different from other human cochlear vessels. These abnormalities seen in the stereocilia, the outer hair cells, and Reissner's membrane are a matter of fact. We must admit, however, that not enough electron microscopic studies have been performed on ears from aging individuals or ears with other pathologies to state that these changes are unique to Ménière's disease. Furthermore, there is currently insufficient knowledge to predict whether these changes affect auditory function.

scholarly journals State of the Art Imaging in Menière’s Disease. Tips and Tricks for Protocol and Interpretation

2020 ◽  
Vol 8 (11) ◽  
Author(s):  
Lisa M. H. de Pont ◽  
Josephine M. van Steekelenburg ◽  
Berit M. Verbist ◽  
Mark A. van Buchem ◽  
Henk M. Blom ◽  
...  
Keyword(s):  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Imaging Features ◽  
Menière's Disease ◽  
Membranous Labyrinth ◽  
Reliable Technique ◽  
Ménière's Disease

Abstract Purpose of Review Menière’s disease (MD) is a burdensome and not well understood inner ear disorder that has received increasing attention of scientists over the past decade. Until 2007, a certain diagnosis of endolymphatic hydrops (EH) required post-mortem histology. Today, dedicated high-resolution magnetic resonance imaging (MRI) protocols enable detection of disease-related changes in the membranous labyrinth in vivo. In this review, we summarize the current status of MR imaging for MD. Recent Findings The mainstays of hydrops imaging are inversion recovery sequences using delayed acquisition after intravenous or intratympanic contrast administration. Based on these techniques, several methods have been developed to detect and classify EH. In addition, novel imaging features of MD, such as blood-labyrinth barrier impairment, have recently been observed. Summary Delayed contrast enhanced MRI has emerged as a reliable technique to demonstrate EH in vivo, with promising application in the diagnosis and follow-up of MD patients. Therefore, familiarity with current techniques and diagnostic imaging criteria is increasingly important.

NA,K-Atpase in the Cochlear Lateral Wall of Human Temporal Bones with Endolymphatic Hydrops

1995 ◽  
Vol 104 (11) ◽  
pp. 858-863 ◽  
Author(s):  
Elizabeth M. Keithley ◽  
Steve Horowitz ◽  
Michael J. Ruckenstein
Keyword(s):  
Stria Vascularis ◽  
Experimental Studies ◽  
Lateral Wall ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Ménière's Disease ◽  
Temporal Bones

Meniere's disease has traditionally been thought to arise from a disruption in longitudinal endolymphatic flow. This view has been brought into question by recent experimental studies that have focused attention on derangements of cochlear fluid and electrolyte homeostatic mechanisms in Meniere's disease, including abnormalities in Na,K-ATPase enzymes found in the cochlear lateral wall. The current study examined the immunohistochemical labeling pattern of the major ion-transporting enzyme of the stria vascularis, Na,K-ATPase, in archival sections of hydropic and nonhydropic human temporal bones for increased density of label that could indicate overproduction of fluid. The results showed good labeling of the stria vascularis in the celloidin sections. The hydropic ears tended to have darker label, but the difference was not statistically significant. The findings are consistent with normal functioning of the stria vascularis in cases of Meniere's disease.

Cochlear Fluid Balance

1980 ◽  
Vol 89 (4) ◽  
pp. 335-341 ◽  
Author(s):  
Arndt J. Duvall ◽  
Peter A. Santi ◽  
Margaret J. Hukee
Keyword(s):  
Acoustic Trauma ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Ménière's Disease ◽  
Reissner's Membrane ◽  
Reissner’S Membrane ◽  
Osmotic Agents

Stria edema, and in some cases atrophy, follows osmotic agents, loop-inhibiting diuretics, acoustic trauma, and rupture of Reissner's membrane. All have in common an imbalance of fluid and electrolytes in the cochlear duct. The glycerol test causes temporary improvement in hearing in Menière's disease. Glycerol causes stria edema and collapse of Reissner's membrane in the chinchilla. Stria edema, as well as stria atrophy, are found in Menière's disease. Metabolic manipulation of the stria might be the best approach in the search for successful treatment of Menière's disease.

Localization, Frequency, and Severity of Endolymphatic Hydrops and the Pathology of the Labyrinthine Membrane in Meniere's Disease

1987 ◽  
Vol 96 (4) ◽  
pp. 438-445 ◽  
Author(s):  
Taeko Okuno ◽  
Isamu Sando
Keyword(s):  
Endolymphatic Hydrops ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Basal Turn ◽  
Ménière's Disease ◽  
Temporal Bones ◽  
Perilymphatic Space

The localization, frequency, and severity of endolymphatic hydrops in 22 temporal bones of 16 individuals with Meniere's disease were studied histopathologically. Endolymphatic hydrops was more often observed in the pars inferior (22/22) than in the pars superior (13/22) of the temporal bone, and severe hydrops was observed most frequently in the saccule, followed by the cochlea, the utricle, and the three semicircular canals. In the cochlea, the most severe hydrops was observed in the apical turn, followed by the hook portion, the middle turn, and the basal turn. Clinically interesting observations regarding endolymphatic hydrops included bulging into the perilymphatic space of the vestibule. In 17 of 22 bones the saccular membrane bulged into the vestibule laterally and was attached to the footplate of the stapes. In two of 22 bones, Reissner's membrane in the hook portion of the basal turn of the cochlea bulged superiorly into the vestibule, occupying most of the perilymphatic space of the vestibule.

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