Effects of acute tryptophan depletion on prepulse inhibition of the acoustic startle (eyeblink) response and the N1/P2 auditory evoked response in man

2000 ◽  
Vol 14 (3) ◽  
pp. 258-265 ◽  
Author(s):  
M. A. Phillips ◽  
E. K. Oxtoby ◽  
R. W. Langley ◽  
C. M. Bradshaw ◽  
E. Szabadi
Keyword(s):  
Prepulse Inhibition ◽  
Acoustic Startle ◽  
Evoked Response ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Eyeblink Response ◽  
Auditory Evoked Response ◽  
Startle Eyeblink

Effects of Quetiapine and Haloperidol on Prepulse Inhibition of the Acoustic Startle (Eyeblink) Response and the N1/P2 Auditory Evoked Response in Man

2004 ◽  
Vol 18 (2) ◽  
pp. 173-180 ◽  
Author(s):  
S. J. Graham ◽  
J. C. Scaife ◽  
A. M. Balboa Verduzco ◽  
R. W. Langley ◽  
C. M. Bradshaw ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
Acoustic Startle ◽  
Evoked Response ◽  
Eyeblink Response ◽  
Auditory Evoked Response ◽  
Startle Eyeblink

Sensorimotor Gating and Attitudes Related to Schizotypal Proneness

2001 ◽  
Vol 88 (3_suppl) ◽  
pp. 1035-1045 ◽  
Author(s):  
Almut I. Weike ◽  
Alfons O. Hamm ◽  
Dieter Vaitl
Keyword(s):  
Prepulse Inhibition ◽  
Sensorimotor Gating ◽  
Schizophrenia Spectrum Disorders ◽  
Eyeblink Response ◽  
Startle Eyeblink ◽  
Psychosis Proneness ◽  
Gating Mechanism ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
Information Processing Deficits

The magnitude of the startle eyeblink response is diminished when the startle-eliciting probe is shortly preceded by another stimulus. This so called prepulse inhibition is interpreted as an automatic sensorimotor gating mechanism. There is substantial support for prepulse inhibition deficits in subjects suffering from schizophrenia spectrum disorders and in psychosis-prone normals as well. Thus, prepulse inhibition deficits may reflect vulnerability on the hypothesized psychopathological continuum from “normal” to “schizophrenia.” The present experiment investigated the amount of prepulse inhibition in a sample selected for “belief in extraordinary phenomena,” an attitude related to measures of psychosis-proneness. Believers and skeptics were tested in an acoustic prepulse-inhibition paradigm. As expected, presentation of prepulses clearly diminished magnitude of startle response, with greatest inhibition effects gained by lead intervals of 60 and 120 msec. Patterns of response were identical for believers and skeptics, i.e., attitude towards extraordinary phenomena did not seem to be related to functional information-processing deficits as has been observed in psychosis-prone normals.

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