Experimental Studies Comparing Iohexol and 51Cr-Edta for Glomerular Filtration Rate Measurements

1995 ◽  
Vol 36 (1) ◽  
pp. 58-63 ◽  
Author(s):  
S. Lundqvist ◽  
S.-O. Hietala ◽  
K. Karp
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Renal Clearance ◽  
Filtration Rate ◽  
Plasma Clearance ◽  
Experimental Studies ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
51Cr Edta

The total plasma clearance as well as the renal clearance of iohexol were evaluated for determination of the glomerular filtration rate (GFR) in 16 anesthetized pigs. The iohexol levels in urine and plasma were measured by X-ray fluorescence. The total plasma clearance of 1 and 4 ml/kg b.w. of iohexol 300 mg I/ml was compared to the simultaneously as well as nonsimultaneously calculated total plasma clearance of 51Cr-EDTA. The total plasma clearance of 51Cr-EDTA and of iohexol turned out to be equal and independent of the injected dose of iohexol. The injected dose did not have any effect on the renal clearance of iohexol either. It is concluded that iohexol and 51Cr-EDTA are similar as marker substances for determination of the GFR.

Simultaneous Urography and Determination of Glomerular Filtration Rate

1994 ◽  
Vol 35 (4) ◽  
pp. 391-395 ◽  
Author(s):  
S. Lundqvist ◽  
S.-O. Hietala ◽  
C. Berglund ◽  
K. Karp
Keyword(s):  
Contrast Medium ◽  
Filtration Rate ◽  
Plasma Clearance ◽  
Patient Comfort ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
X Ray ◽  
Multiple Sample ◽  
Fluorescence Analyzer

The total plasma clearance of iohexol at urography and 51Cr-EDTA was compared in 31 patients with di- or tetraparesis. A reference 51Cr-EDTA clearance was also performed 24 hours prior to the urography. The GFR was calculated from one, 2 or 4 plasma samples collected 180, 210, 240 and 270 min after the injection. An X-ray fluorescence analyzer was used for the analysis of iohexol in plasma as well as the contrast medium clearance calculations. It was shown that single or multiple sample clearance of iohexol and 51Cr-EDTA were equivalent methods for measurement of the GFR. The GFR was not affected by iohexol in a dose routinely used for urography. It was concluded that the patient comfort is improved if 51Cr-EDTA clearance is replaced by contrast medium clearance in association with urography.

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