A Case of Adenocarcinoma of the Upper Third of the Esophagus Arising on Ectopic Gastric Tissue.

1974 ◽  
Vol 60 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Claudio Clemente
Keyword(s):  
Gastric Mucosa ◽  
Esophageal Adenocarcinoma ◽  
Ectopic Gastric Mucosa ◽  
Gastric Tissue ◽  
Gastric Type ◽  
Upper Third

A case of adenocarcinoma of the upper third of the esophagus, arising from ectopic mucosa of gastric type, is described. The possible origins, from ectopic islets of gastric mucosa, tracheobronchial rests or esophageal glands, are discussed. The precence of ectopic gastric mucosa on the surface of the esophagus adjacent to the tumor suggests that this esophageal adenocarcinoma arose from ectopic gastric mucosa.

Esophageal Adenocarcinoma with Enteroblastic Differentiation Arising in Ectopic Gastric Mucosa in the Cervical Esophagus: a Case Report and Literature Review

2017 ◽  
Vol 26 (2) ◽  
pp. 193-197 ◽  
Author(s):  
Ryosuke Gushima ◽  
Rei Narita ◽  
Takashi Shono ◽  
Hideaki Naoe ◽  
Takashi Yao ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Esophageal Adenocarcinoma ◽  
Histopathological Examination ◽  
Narrow Band Imaging ◽  
Carbohydrate Antigen ◽  
Endoscopic Examination ◽  
Ectopic Gastric Mucosa ◽  
Tubular Adenocarcinoma ◽  
Positron Emission ◽  
Elevated Lesion

Background: Adenocarcinoma with enteroblastic differentiation is a subtype of alpha-fetoprotein (AFP) producing adenocarcinoma. This type of tumor is associated with a poor prognosis and is prone to metastasize. Esophageal adenocarcinoma with enteroblastic differentiation is extremely rare.Case presentation: The patient was a 65-year-old woman who was referred to our hospital with dysphagia. Endoscopic examination revealed an elevated lesion 20mm in diameter at 17cm from the upper incisors. Endoscopic submucosa dissection (ESD) was performed and histopathological examination revealed tubular adenocarcinoma composed of cuboidal cells with clear cell cytoplasm. Immunohistochemical stain was diffusely positive for Sall-like protein 4 (SALL4) and weakly positive for AFP and glypican 3. From this result, we diagnosed esophageal adenocarcinoma with enteroblastic differentiation. The patient is still alive without recurrence of cancer 40 months after ESD.Conclusion: To our knowledge, this is the first report to undergo ESD for esophageal adenocarcinoma with enteroblastic differentiation arising from ectopic gastric mucosa in the esophagus.Abbreviations: AFP: alfa-fetoprotein; CA19-9: carbohydrate antigen 19-9; CEA: carcinoembryonic antigen; ESD: endoscopic submucosal dissection; EUS: endoscopic ultrasound; FDG-PET: [18F] fluorodeoxyglucose positron emission tomography; ME: magnifying endoscopy; NBI: narrow band imaging; SALL 4: Sall-like protein 4; SCC: squamous cell carcinoma antigen.

scholarly journals A CASE OF PRIMARY UPPER INTRA-THORACIC ESOPHAGEAL ADENOCARCINOMA IN ECTOPIC GASTRIC MUCOSA IN AN ELDERLY PATIENT

1994 ◽  
Vol 55 (2) ◽  
pp. 390-394 ◽  
Author(s):  
Yu TAKAGI ◽  
Shigeru SATO ◽  
Osamu KOGANEZAWA ◽  
Masato MORITANI ◽  
Naoki KURODA ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Gastric Mucosa ◽  
Esophageal Adenocarcinoma ◽  
Ectopic Gastric Mucosa

scholarly journals A case of cervical esophageal adenocarcinoma arising from ectopic gastric mucosa

2013 ◽  
Vol 82 (1) ◽  
pp. 106-107 ◽  
Author(s):  
Daisuke Ochi ◽  
Toshiaki Narasaka ◽  
Daisuke Akutsu ◽  
Katsumasa Kobayashi ◽  
Akinori Sugaya ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Esophageal Adenocarcinoma ◽  
Ectopic Gastric Mucosa

scholarly journals A case of esophageal adenocarcinoma arising from the ectopic gastric mucosa in the thoracic esophagus

Rare Tumors ◽  
2010 ◽  
Vol 2 (1) ◽  
pp. 12-15
Author(s):  
Shuji Komori ◽  
Shinji Osada ◽  
Yoshihiro Tanaka ◽  
Takao Takahashi ◽  
Narutoshi Nagao ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Lymph Nodes ◽  
Esophageal Adenocarcinoma ◽  
Ectopic Gastric Mucosa ◽  
Thoracic Esophagus ◽  
Pathological Study ◽  
Subtotal Esophagectomy

A 75-year old man was detected with a pediculate tumor in the upper esophagus. A biopsy determined that it was an adenocarcinoma. A subtotal esophagectomy with dissection of three-fields of lymph nodes was selected. The pathological study revealed it to be an esophageal adenocarcinoma arising from ectopic gastric mucosa of the fundus of the stomach. His post-operative course was uneventful and without sign of recurrence for 3.5 years.

scholarly journals A CASE OF ESOPHAGEAL ADENOCARCINOMA ARISING FROM ECTOPIC GASTRIC MUCOSA IN THE CERVICO-THORACIC ESOPHAGUS

2004 ◽  
Vol 65 (10) ◽  
pp. 2637-2641 ◽  
Author(s):  
Naoki KAGAWA ◽  
Yasuhiko FUKUDA ◽  
Tatsuro ISHIMOTO ◽  
Yasuhiro MATSUGU ◽  
Hideki NAKAHARA ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Esophageal Adenocarcinoma ◽  
Ectopic Gastric Mucosa ◽  
Thoracic Esophagus

scholarly journals Symptomatic Heterotopic Gastric Mucosa in Distal Esophagus

2021 ◽  
Author(s):  
Avnish Kumar Seth ◽  
Mahesh Kumar Gupta ◽  
Gursimran Kaur ◽  
Priti Jain ◽  
Rinkesh Kumar Bansal
Keyword(s):  
Gastric Mucosa ◽  
Squamous Epithelium ◽  
Narrow Band Imaging ◽  
Distal Esophagus ◽  
Heterotopic Gastric Mucosa ◽  
Retrosternal Pain ◽  
Gastric Type ◽  
History Of ◽  
Mass Lesions

Abstract Introduction Heterotopic gastric mucosa (HGM) in esophagus is commonly noted as an inlet patch at endoscopy. We describe a rare patient with symptomatic distal esophageal HGM. Case Report A 40-year-old male presented with retrosternal pain and marked odynophagia for the last 4 weeks without any history of ingestion of antibiotics, foreign body, or corrosive. Endoscopy showed abrupt circumferential transition to salmon pink mucosa at 35 cm from incisors. From 35 to 41 cm, there were areas of polypoid edematous thickening with few superficial ulcers of 1 to 3 mm. Squamous epithelium was visualized at narrow band imaging from 41 cm to the Z-line at 43 cm with no hiatus hernia. Biopsy showed gastric-type mucosa with parietal cells without dysplasia. Serology for cytomegalovirus and human immunodeficiency virus was negative. He was managed with proton pump inhibitors (PPIs) and prokinetics and improved symptomatically. Follow-up endoscopy at 3 months demonstrated healing of ulcers with persistence of HGM and pseudopolyps. He remains well on maintenance with PPI at 1-year follow-up. Conclusion Symptomatic HGM in distal esophagus is rare and can be differentiated from Barrett’s esophagus histologically and by presence of squamous epithelium between HGM and stomach. Inflammatory mass lesions may develop and mimic esophageal malignancy. Symptoms are largely due to acid production and usually respond to PPI.

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