Esophageal Adenocarcinoma with Enteroblastic Differentiation Arising in Ectopic Gastric Mucosa in the Cervical Esophagus: a Case Report and Literature Review

2017 ◽  
Vol 26 (2) ◽  
pp. 193-197 ◽  
Author(s):  
Ryosuke Gushima ◽  
Rei Narita ◽  
Takashi Shono ◽  
Hideaki Naoe ◽  
Takashi Yao ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Esophageal Adenocarcinoma ◽  
Histopathological Examination ◽  
Narrow Band Imaging ◽  
Carbohydrate Antigen ◽  
Endoscopic Examination ◽  
Ectopic Gastric Mucosa ◽  
Tubular Adenocarcinoma ◽  
Positron Emission ◽  
Elevated Lesion

Background: Adenocarcinoma with enteroblastic differentiation is a subtype of alpha-fetoprotein (AFP) producing adenocarcinoma. This type of tumor is associated with a poor prognosis and is prone to metastasize. Esophageal adenocarcinoma with enteroblastic differentiation is extremely rare.Case presentation: The patient was a 65-year-old woman who was referred to our hospital with dysphagia. Endoscopic examination revealed an elevated lesion 20mm in diameter at 17cm from the upper incisors. Endoscopic submucosa dissection (ESD) was performed and histopathological examination revealed tubular adenocarcinoma composed of cuboidal cells with clear cell cytoplasm. Immunohistochemical stain was diffusely positive for Sall-like protein 4 (SALL4) and weakly positive for AFP and glypican 3. From this result, we diagnosed esophageal adenocarcinoma with enteroblastic differentiation. The patient is still alive without recurrence of cancer 40 months after ESD.Conclusion: To our knowledge, this is the first report to undergo ESD for esophageal adenocarcinoma with enteroblastic differentiation arising from ectopic gastric mucosa in the esophagus.Abbreviations: AFP: alfa-fetoprotein; CA19-9: carbohydrate antigen 19-9; CEA: carcinoembryonic antigen; ESD: endoscopic submucosal dissection; EUS: endoscopic ultrasound; FDG-PET: [18F] fluorodeoxyglucose positron emission tomography; ME: magnifying endoscopy; NBI: narrow band imaging; SALL 4: Sall-like protein 4; SCC: squamous cell carcinoma antigen.

A Case of Adenocarcinoma of the Upper Third of the Esophagus Arising on Ectopic Gastric Tissue.

1974 ◽  
Vol 60 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Claudio Clemente
Keyword(s):  
Gastric Mucosa ◽  
Esophageal Adenocarcinoma ◽  
Ectopic Gastric Mucosa ◽  
Gastric Tissue ◽  
Gastric Type ◽  
Upper Third

A case of adenocarcinoma of the upper third of the esophagus, arising from ectopic mucosa of gastric type, is described. The possible origins, from ectopic islets of gastric mucosa, tracheobronchial rests or esophageal glands, are discussed. The precence of ectopic gastric mucosa on the surface of the esophagus adjacent to the tumor suggests that this esophageal adenocarcinoma arose from ectopic gastric mucosa.

scholarly journals A CASE OF PRIMARY UPPER INTRA-THORACIC ESOPHAGEAL ADENOCARCINOMA IN ECTOPIC GASTRIC MUCOSA IN AN ELDERLY PATIENT

1994 ◽  
Vol 55 (2) ◽  
pp. 390-394 ◽  
Author(s):  
Yu TAKAGI ◽  
Shigeru SATO ◽  
Osamu KOGANEZAWA ◽  
Masato MORITANI ◽  
Naoki KURODA ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Gastric Mucosa ◽  
Esophageal Adenocarcinoma ◽  
Ectopic Gastric Mucosa

scholarly journals A case of cervical esophageal adenocarcinoma arising from ectopic gastric mucosa

2013 ◽  
Vol 82 (1) ◽  
pp. 106-107 ◽  
Author(s):  
Daisuke Ochi ◽  
Toshiaki Narasaka ◽  
Daisuke Akutsu ◽  
Katsumasa Kobayashi ◽  
Akinori Sugaya ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Esophageal Adenocarcinoma ◽  
Ectopic Gastric Mucosa

scholarly journals Hepatic Pseudolymphoma with Fluorodeoxyglucose Uptake on Positron Emission Tomography

2017 ◽  
Vol 10 (3) ◽  
pp. 826-835 ◽  
Author(s):  
Kazuhiro Suzumura ◽  
Etsuro Hatano ◽  
Toshihiro Okada ◽  
Yasukane Asano ◽  
Naoki Uyama ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Histopathological Examination ◽  
Standard Uptake Value ◽  
Carbohydrate Antigen ◽  
Hepatic Tumor ◽  
Emission Tomography ◽  
Abdominal Ultrasonography ◽  
Protein Levels ◽  
Normal Limits ◽  
Positron Emission

A 69-year-old woman with chronic hepatitis B was admitted to our hospital with a hepatic tumor. The levels of 2 tumor markers, carcinoembryonic antigen and carbohydrate antigen 19-9, were slightly elevated; however, the α-fetoprotein and protein levels induced by vitamin K antagonist II were within the normal limits. Abdominal ultrasonography showed a well-defined peripheral hypoechoic mass that was isoechoic and homogeneous on the inside. Computed tomography showed a poorly enhanced tumor of 13 mm in diameter in the 5th segment of the liver. Fluorodeoxyglucose positron emission tomography showed a slight uptake (maximum standard uptake value 3.4) by the hepatic tumor. These findings suggested cholangiocellular carcinoma, and we performed anterior segmentectomy of the liver. A histopathological examination showed a hepatic pseudolymphoma. The patient’s postoperative course was uneventful, and she remains alive without recurrence 5 months after undergoing surgery. In most cases, hepatic pseudolymphoma is preoperatively diagnosed as a malignant tumor and a definite diagnosis is made after resection. It is therefore necessary to consider hepatic pseudolymphoma as a differential diagnosis in patients with hepatic tumors.

scholarly journals A case of esophageal adenocarcinoma arising from the ectopic gastric mucosa in the thoracic esophagus

Rare Tumors ◽  
2010 ◽  
Vol 2 (1) ◽  
pp. 12-15
Author(s):  
Shuji Komori ◽  
Shinji Osada ◽  
Yoshihiro Tanaka ◽  
Takao Takahashi ◽  
Narutoshi Nagao ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Lymph Nodes ◽  
Esophageal Adenocarcinoma ◽  
Ectopic Gastric Mucosa ◽  
Thoracic Esophagus ◽  
Pathological Study ◽  
Subtotal Esophagectomy

A 75-year old man was detected with a pediculate tumor in the upper esophagus. A biopsy determined that it was an adenocarcinoma. A subtotal esophagectomy with dissection of three-fields of lymph nodes was selected. The pathological study revealed it to be an esophageal adenocarcinoma arising from ectopic gastric mucosa of the fundus of the stomach. His post-operative course was uneventful and without sign of recurrence for 3.5 years.

scholarly journals Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Fukuko Shimizu ◽  
Kenji Okami ◽  
Koji Ebisumoto ◽  
Daisuke Maki ◽  
Akihiro Sakai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Outpatient Setting ◽  
Endoscopic Examination ◽  
Unknown Primary ◽  
Tonsillar Carcinoma ◽  
Positron Emission

Background. The incidence of human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) has been rapidly increasing worldwide. HPV is reported in approximately 50% cases of OPSCC in Japan. However, there are few reports of synchronous bilateral HPV-positive tonsillar carcinoma, and, in almost all those cases, carcinoma was detected using positron emission tomography/computed tomography and/or bilateral tonsillectomy. Methods and Results. We report the case of a 63-year-old male with bilateral tonsillar carcinoma detected using transoral endoscopic examination with narrow-band imaging (NBI). A biopsy of the bilateral tonsils revealed squamous cell carcinoma, which was demonstrated to be HPV-related using in situ hybridization and p16 immunohistochemistry. The patient was diagnosed as synchronous bilateral tonsillar carcinoma: T1 (2) N2b M0. He was treated with induction chemotherapy, bilateral radical tonsillectomy with neck dissection, and radiotherapy. Conclusion. To our knowledge, this is the first report of a synchronous bilateral tonsillar carcinoma detected using transoral NBI in the outpatient setting. Early diagnosis without the inspection under general anesthesia is beneficial for the patients with lymph node metastasis from unknown primary lesion.

scholarly journals Narrow band imaging of adenocarcinoma arising from ectopic gastric mucosa in the upper esophagus

Endoscopy ◽  
2013 ◽  
Vol 45 (S 02) ◽  
pp. E112-E113 ◽  
Author(s):  
K. Nonaka ◽  
M. Watanabe ◽  
H. Yuruki ◽  
A Okuda ◽  
K. Sakurai ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Ectopic Gastric Mucosa
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