Malignant Transformation Arising Within Unusual and Rare Hepatic Lesions: Fibropolycystic Disease Form of Ductal Plate Malformation and Biliary Adenofibroma

2018 ◽  
Vol 26 (6) ◽  
pp. 542-550 ◽  
Author(s):  
Darren Chua ◽  
Adrian Kah Heng Chiow ◽  
Tiing Leong Ang ◽  
Lai Mun Wang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Malignant Transformation ◽  
Intrahepatic Cholangiocarcinoma ◽  
Ductal Plate ◽  
Hepatobiliary Cancer ◽  
Ductal Plate Malformation ◽  
Biliary Adenofibroma ◽  
Hepatic Lesions

Cholangiocarcinoma is the second most common hepatobiliary cancer following hepatocellular carcinoma, and 20% to 25% are intrahepatic. We describe 2 cases of intrahepatic cholangiocarcinoma arising within unusual and rare hepatic lesions, fibropolycystic liver disease form of ductal plate malformation and biliary adenofibroma, whose association with malignancy is rarely reported in the literature.

scholarly journals Intrahepatic Cholangiocarcinoma with Ductal Plate Malformation-like Feature Associated with Bile Duct Adenoma

2015 ◽  
Vol 49 (6) ◽  
pp. 531-534 ◽  
Author(s):  
Ah-Young Kwon ◽  
Hye Jin Lee ◽  
Hee Jung An ◽  
Haeyoun Kang ◽  
Jin-Hyung Heo ◽  
...  
Keyword(s):  
Bile Duct ◽  
Intrahepatic Cholangiocarcinoma ◽  
Ductal Plate ◽  
Ductal Plate Malformation ◽  
Bile Duct Adenoma

scholarly journals Liver-specific magnetic resonance contrast medium in the evaluation of chronic liver disease

2015 ◽  
Vol 13 (2) ◽  
pp. 326-329
Author(s):  
Marcio Augusto Correia Rodrigues dos Reis ◽  
Ronaldo Hueb Baroni
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Contrast Medium ◽  
Chronic Liver Disease ◽  
Hepatic Function ◽  
Chronic Liver ◽  
Hepatobiliary Phase ◽  
Hepatocellular Carcinomas ◽  
Focal Hepatic Lesions ◽  
Hepatic Lesions

ABSTRACT The hepatobiliary-specific contrast medium (gadoxetic acid – Primovist®) is primarily used to improve detection and characterization of focal hepatic lesions, such as in chronic liver disease patients with suspected hepatocellular carcinoma. Since the contrast medium is selectively taken up by functioning hepatocytes in the late hepatobiliary phase, it helps to detect typical hepatocellular carcinoma, which show low signal intensity on this phase. This imaging feature also assists in differentiating regenerative/dysplastic nodules from early hepatocellular carcinomas (with over 90% accuracy), as well as hypervascular hepatocellular carcinomas from arterial pseudo-enhancement foci. Future perspectives include its use in quantification of hepatic function and fibrosis.

Intrahepatic Cholangiocarcinoma With Predominant “Ductal Plate Malformation” Pattern

2012 ◽  
Vol 36 (11) ◽  
pp. 1629-1635 ◽  
Author(s):  
Yasuni Nakanuma ◽  
Yasunori Sato ◽  
Hiroko Ikeda ◽  
Kenichi Harada ◽  
Mikiko Kobayashi ◽  
...  
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Ductal Plate ◽  
Ductal Plate Malformation

scholarly journals Significance of posterior acoustic enhancement ultrasonographic findings in the diagnosis of hepatocellular carcinoma

2019 ◽  
Vol 72 (5-6) ◽  
pp. 160-164
Author(s):  
Jelena Stosic ◽  
Srdjan Stosic ◽  
Biljana Kukic ◽  
Mladjan Protic
Keyword(s):  
Hepatocellular Carcinoma ◽  
Retrospective Study ◽  
Liver Disease ◽  
Ultrasound Examination ◽  
Significant Finding ◽  
Focal Lesions ◽  
Hepatocellular Carcinomas ◽  
Focal Hepatic Lesions ◽  
Patients At Risk ◽  
Hepatic Lesions

Introduction. On ultrasound, hepatocellular carcinoma presents with nodular or multinodular lesions of different size and echostructure, sometimes with a surrounding halo, and lateral acoustic shadows or posterior acoustic enhancement. The aim of this study was to determine the incidence of posterior acoustic enhancement in hepatocellular carcinoma. Material and Methods. This retrospective study included 120 patients with pathologically verified hepatocellular carcinoma who had undergone ultrasound examination (using real time ultrasounds from different manufacturers, with 3.5 and 5 MHz probes). Ultrasound imaging focused on the size and appearance of the focal lesions, i. e. echostructure and presence or absence of posterior acoustic enhancement as areas of increased echogenicity behind the lesion. Results. Posterior acoustic enhancement was observed in 47.3% of all nodular hepatocellular carcinomas, whereas this ultrasound phenomenon was statistically significantly more common in the group of tumors from 3 to 5 cm in size. In the group of multinodular tumors, posterior acoustic enhancement was found in 70% of cases. Conclusion. The presence of posterior acoustic enhancement in the detection of focal hepatic lesions may be a significant finding in the diagnosis of hepatocellular carcinoma, especially in patients at risk for developing hepatocellular carcinoma (cirrhosis and chronic liver disease), as well as in monitoring interval growth in size of focal lesions using this ultrasound phenomenon.

scholarly journals Intrahepatic Cholangiocarcinoma: Clinical Aspects, Pathology and Treatment

HPB Surgery ◽  
1992 ◽  
Vol 5 (2) ◽  
pp. 95-102 ◽  
Author(s):  
Richard T. Schlinkert ◽  
David M. Nagorney ◽  
Jon A. van Heerden ◽  
Martin A. Adson
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Intrahepatic Cholangiocarcinoma ◽  
Advanced Disease ◽  
Disease Stage ◽  
Clinical Aspects ◽  
Underlying Liver Disease ◽  
Clinical Presentations ◽  
Advanced Disease Stage ◽  
Disease Free

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary tumor of the liver. To further define its clinicopathology and surgical management, we reviewed our experience. Clinical presentations of 32 patients with ICC was similar to that with hepatocellular carcinoma. Jaundice occurred in only 27 percent. ICC was unresectable due to advanced disease stage in 81 percent. Six patients had curative resections with two 5 year disease free survivors. Underlying liver disease was associated with ICC in 34 percent of patients.

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