Reproducibility of macular retinal nerve fiber layer and ganglion cell layer thickness measurements in a healthy pediatric population

2020 ◽  
pp. 112067212094761
Author(s):  
Maria Jiménez Santos ◽  
Alejandra Acebal Montero ◽  
Federico Sáenz-Francés San Baldomero ◽  
Alcia Valverde-Megias ◽  
Rosario Gómez de Liaño
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Age Groups ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Intraobserver Reproducibility ◽  
Retinal Nerve Fiber

Purpose: To evaluate the reproducibility of Spectralis spectral domain-OCT segmented ganglion cell layer (GCL) and macular retinal nerve fiber layer (mRNFL) measurements in a healthy children population. Methods: An observational, cross-sectional study was carried out on 79 children to measure the intraobserver reproducibility and the repeatability between a novel and an experienced operator of the segmented macular GCL and mRNFL. Interobserver and intraobserver reproducibility were defined by the intraclass correlation coefficient (ICC) and coefficients of variation (COV). Kruskal–Wallis test was used to determine statistical significance in the COV of three age groups children (younger than 6 years, between 6 and 12, and older than 12 years old). Results: The results from the intraoperator GCL thickness analysis were highly reproducible (COV < 6%) and reliable (ICCs > 0.81). When the measurements were compared between a novel and an experienced examiner lower ICCs and higher COV were found. COVs ranged from 1.85% (total volume area) to 5.57% at the central ETDRS subfield while the ICC vary from 0.632 (outer inferior) to 0.832 (inner inferior). The repeatability and reproducibility of the mRNFL thickness were lower, with ICCs ranging from 0.428 to 0.872 in the interobserver analysis and from 0.897 to 0.346 in the interobserver one. Conclusion: In the present study, we establish substantial reliability of the GCL thickness in children with Spectralis® SD-OCT in all the sectors, albeit lower than the reported in the literature with other SD-OCTs and in adults. The reproducibility and repeatability of the mRNFL were significantly lower. We were unable to find consistent statistical significant differences between the COV of the three age groups.

Effects of chronic methamphetamine abuse on the retinal nerve fiber layer, ganglion cell layer and Bruch’s membrane opening minimum rim width

2020 ◽  
Vol 80 ◽  
pp. 140-143
Author(s):  
Mohammad Reza Talebnejad ◽  
Peyman Khazaei ◽  
Hamidreza Jahanbani-Ardakani ◽  
Zahra Saberikia ◽  
Ebrahim Moghimi Sarani ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Fiber Layer ◽  
Methamphetamine Abuse ◽  
Nerve Fiber Layer ◽  
Bruch’S Membrane Opening ◽  
Retinal Nerve Fiber

Retinal nerve fiber layer and ganglion cell layer thickness in patients receiving systemic isotretinoin therapy

2013 ◽  
Vol 33 (5) ◽  
pp. 481-484 ◽  
Author(s):  
Berrak Sekeryapan ◽  
Nursel Dılek ◽  
Veysi Oner ◽  
Kemal Turkyılmaz ◽  
Mehmet Gokhan Aslan
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Isotretinoin Therapy ◽  
Retinal Nerve Fiber

Evaluation of retinal nerve fiber layer, ganglion cell layer and macular changes in patients with migraine

2016 ◽  
Vol 117 (1) ◽  
pp. 121-129 ◽  
Author(s):  
Abdulkadir Tunç ◽  
Belma Doğan Güngen ◽  
Ferhat Evliyaoğlu ◽  
Yeşim Güzey Aras ◽  
Aysel Kaya Tekeşin
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

Effect of duration and severity of migraine on retinal nerve fiber layer, ganglion cell layer, and choroidal thickness

2018 ◽  
Vol 28 (6) ◽  
pp. 714-721 ◽  
Author(s):  
Mona K Abdellatif ◽  
Mohamed M Fouad
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Choroidal Thickness ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Determinant Factor ◽  
Retinal Nerve Fiber

Purpose: To investigate the factors in migraine that have the highest significance on retinal and choroidal layers’ thickness. Methods: Ninety patients with migraine and 40 age-matched healthy participants were enrolled in this observational, cross-sectional study. After full ophthalmological examination, spectral domain-optical coherence tomography was done for all patients measuring the thickness of ganglion cell layer and retinal nerve fiber layer. Enhanced depth imaging technique was used to measure the choroidal thickness. Results: There was significant thinning in the superior and inferior ganglion cell layers, all retinal nerve fiber layer quadrants, and all choroidal quadrants (except for the central subfield) in migraineurs compared to controls. The duration of migraine was significantly correlated with ganglion cell layer, retinal nerve fiber layer, and all choroidal quadrants, while the severity of migraine was significantly correlated with ganglion cell layer and retinal nerve fiber layer only. Multiregression analysis showed that the duration of migraine is the most important determinant factor of the superior retinal nerve fiber layer quadrant (β = −0.375, p = 0.001) and in all the choroidal quadrants (β = −0.531, −0.692, −0.503, −0.461, −0.564, respectively, p  < 0.001), while severity is the most important determinant factor of inferior, nasal, and temporal retinal nerve fiber layer quadrants (β = −0.256, −0.335, −0.308; p  = 0.036, 0.005, 0.009, respectively) and the inferior ganglion cell layer hemisphere (β = −0.377 and p = 0.001). Conclusion: Ganglion cell layer, retinal nerve fiber layer, and choroidal thickness are significantly thinner in patients with migraine. The severity of migraine has more significant influence in the thinning of ganglion cell layer and retinal nerve fiber layer, while the duration of the disease affected the choroidal thickness more.

[P4-058]: RETINAL NERVE FIBER LAYER AND GANGLION CELL LAYER VOLUME CHANGES IN PRECLINICAL ALZHEIMER'S DISEASE OVER 27 MONTHS

2017 ◽  
Vol 13 (7S_Part_26) ◽  
pp. P1280-P1280 ◽  
Author(s):  
Cláudia Y. Santos ◽  
Lenworth N. Johnson ◽  
Yen Ying Lim ◽  
Brian M. Fernandez ◽  
Brian R. Ott ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Volume Changes ◽  
Preclinical Alzheimer’S Disease ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

Evaluation of Retinal Neurodegeneration and Choroidal Thickness in Patients with Inactive Gravesʼ Ophthalmopathy

2021 ◽  
Author(s):  
Muhammed M. Kurt ◽  
Cetin Akpolat ◽  
Ferhat Evliyaoglu ◽  
Merve Yilmaz ◽  
Fikriye Ordulu
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Choroidal Thickness ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
And Control ◽  
Retinal Nerve Fiber

Abstract Purpose The study was conducted for the assessment of the retinal nerve fiber layer, ganglion cell layer, and subfoveal choroidal thickness changes in patients with inactive Gravesʼ ophthalmopathy (GO) using swept-source optical coherence tomography (SS-OCT) before the development of active GO findings. Materials and Methods The cross-sectional designed study consisted of patients with inactive Gravesʼ ophthalmopathy (study group) and healthy subjects (control group). The thicknesses of the retinal ganglion cell layer, retinal nerve fiber layer, and subfoveal choroid (SFCT) were measured using SS-OCT with deep range imaging technology to compare these parameters between the study and control groups. Result Patients with inactive Gravesʼ ophthalmopathy had higher values of intraocular pressure but similar best-corrected visual acuity (p = 0.001, p = 0.232, respectively). The retinal nerve fiber layer was thinner only in the superior zone of the study group (p = 0.039), whereas similar values were noted in the temporal, nasal, and inferior areas as well as the average thickness. We did not observe any statistically significant difference in any sector of the ganglion cell layer between the study and control groups. A thicker mean subfoveal choroidal thickness value was measured in patients with inactive Gravesʼ ophthalmopathy than in healthy subjects (p = 0.013) in correlation with a clinical activity score (p = 0.046). Conclusion SS-OCT showed minimal retinal neurodegenerative alteration and significant choroidal thickening in inactive GO. Thus, SS-OCT might be a beneficial technique to detect retinal neurodegenerative and choroidal changes earlier in the stage of inactive GO before the development of active GO signs, which may affect the time and type of treatment modalities to prevent further ocular or systemic complications. Additionally, SFCT may be a good indicator for assessment of the severity of Gravesʼ disease.

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