scholarly journals Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Chih-Lung Chen ◽  
Wen-Yen Huang ◽  
Eddy Hsi Chun Wang ◽  
Kang-Yu Tai ◽  
Sung-Jan Lin
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Therapeutic Targeting ◽  
Hair Follicle Stem Cell ◽  
Hair Regeneration ◽  
Functional Complexity ◽  
Cell Niche

BMP signaling in the hair follicle stem cell niche regulates hair growth and skin pigmentation

2017 ◽  
Vol 86 (2) ◽  
pp. e60 ◽  
Author(s):  
Carlos Clavel ◽  
Delia Quek ◽  
Jamien Lim ◽  
Shuan Yong Teo
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Hair Growth ◽  
Stem Cell Niche ◽  
Skin Pigmentation ◽  
Bmp Signaling ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

scholarly journals Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

2019 ◽  
Vol 38 (19) ◽  
Author(s):  
Daniel Peña‐Jimenez ◽  
Silvia Fontenete ◽  
Diego Megias ◽  
Coral Fustero‐Torre ◽  
Osvaldo Graña‐Castro ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Lymphatic Vessels ◽  
Skin Regeneration ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

The Hair Follicle Stem Cell Niche: The Bulge and Its Environment

2015 ◽  
pp. 1-26
Author(s):  
Alex B. Wang ◽  
Prachi Jain ◽  
Tudorita Tumbar
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

scholarly journals 687 BMP signaling in the hair follicle stem cell niche regulates hair growth and skin pigmentation

2016 ◽  
Vol 136 (5) ◽  
pp. S122
Author(s):  
J. Lim ◽  
D. Quek ◽  
J. Tan ◽  
C. Clavel
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Hair Growth ◽  
Stem Cell Niche ◽  
Skin Pigmentation ◽  
Bmp Signaling ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

scholarly journals The dermal sheath: An emerging component of the hair follicle stem cell niche

2020 ◽  
Author(s):  
Pieter A. Martino ◽  
Nicholas Heitman ◽  
Michael Rendl
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

scholarly journals A Dominant Role of the Hair Follicle Stem Cell Niche in Regulating Melanocyte Stemness

2010 ◽  
Vol 6 (2) ◽  
pp. 95-96 ◽  
Author(s):  
Cédric Blanpain ◽  
Panagiota A. Sotiropoulou
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Dominant Role ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

scholarly journals Erratum: Corrigendum: Therapeutic targeting of a stem cell niche

2008 ◽  
Vol 26 (2) ◽  
pp. 241-241 ◽  
Author(s):  
Gregor B Adams ◽  
Roderick P Martin ◽  
Ian R Alley ◽  
Karissa T Chabner ◽  
Kenneth S Cohen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Therapeutic Targeting ◽  
Cell Niche

scholarly journals FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential

2016 ◽  
Vol 113 (11) ◽  
pp. E1506-E1515 ◽  
Author(s):  
Kenneth Lay ◽  
Tsutomu Kume ◽  
Elaine Fuchs
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Tissue Growth ◽  
Hair Cycle ◽  
Forkhead Box ◽  
Stem Cell Quiescence ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

Adult tissue stem cells (SCs) reside in niches, which orchestrate SC behavior. SCs are typically used sparingly and exist in quiescence unless activated for tissue growth. Whether parsimonious SC use is essential to conserve long-term tissue-regenerating potential during normal homeostasis remains poorly understood. Here, we examine this issue by conditionally ablating a key transcription factor Forkhead box C1 (FOXC1) expressed in hair follicle SCs (HFSCs). FOXC1-deficient HFSCs spend less time in quiescence, leading to markedly shortened resting periods between hair cycles. The enhanced hair cycling accelerates HFSC expenditure, and impacts hair regeneration in aging mice. Interestingly, although FOXC1-deficient HFs can still form a new bulge that houses HFSCs for the next hair cycle, the older bulge is left unanchored. As the new hair emerges, the entire old bulge, including its reserve HFSCs and SC-inhibitory inner cell layer, is lost. We trace this mechanism first, to a marked increase in cell cycle-associated transcripts upon Foxc1 ablation, and second, to a downstream reduction in E-cadherin–mediated inter-SC adhesion. Finally, we show that when the old bulge is lost with each hair cycle, overall levels of SC-inhibitory factors are reduced, further lowering the threshold for HFSC activity. Taken together, our findings suggest that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis.

scholarly journals Slc1a3-CreER as a Targeting Tool for the K6+ Epithelial Stem Cell Niche and its Precursors during Mouse Hair Follicle Cycle

2017 ◽  
Vol 137 (7) ◽  
pp. 1569-1571 ◽  
Author(s):  
Aiko Sada ◽  
Prachi Jain ◽  
Sherry Wang ◽  
Eva Leung ◽  
Tudorita Tumbar
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Epithelial Stem Cell ◽  
Hair Follicle Cycle ◽  
Cell Niche
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