scholarly journals Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

2019 ◽  
Vol 38 (19) ◽  
Author(s):  
Daniel Peña‐Jimenez ◽  
Silvia Fontenete ◽  
Diego Megias ◽  
Coral Fustero‐Torre ◽  
Osvaldo Graña‐Castro ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Lymphatic Vessels ◽  
Skin Regeneration ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

BMP signaling in the hair follicle stem cell niche regulates hair growth and skin pigmentation

2017 ◽  
Vol 86 (2) ◽  
pp. e60 ◽  
Author(s):  
Carlos Clavel ◽  
Delia Quek ◽  
Jamien Lim ◽  
Shuan Yong Teo
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Hair Growth ◽  
Stem Cell Niche ◽  
Skin Pigmentation ◽  
Bmp Signaling ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

scholarly journals FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential

2016 ◽  
Vol 113 (11) ◽  
pp. E1506-E1515 ◽  
Author(s):  
Kenneth Lay ◽  
Tsutomu Kume ◽  
Elaine Fuchs
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Tissue Growth ◽  
Hair Cycle ◽  
Forkhead Box ◽  
Stem Cell Quiescence ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

Adult tissue stem cells (SCs) reside in niches, which orchestrate SC behavior. SCs are typically used sparingly and exist in quiescence unless activated for tissue growth. Whether parsimonious SC use is essential to conserve long-term tissue-regenerating potential during normal homeostasis remains poorly understood. Here, we examine this issue by conditionally ablating a key transcription factor Forkhead box C1 (FOXC1) expressed in hair follicle SCs (HFSCs). FOXC1-deficient HFSCs spend less time in quiescence, leading to markedly shortened resting periods between hair cycles. The enhanced hair cycling accelerates HFSC expenditure, and impacts hair regeneration in aging mice. Interestingly, although FOXC1-deficient HFs can still form a new bulge that houses HFSCs for the next hair cycle, the older bulge is left unanchored. As the new hair emerges, the entire old bulge, including its reserve HFSCs and SC-inhibitory inner cell layer, is lost. We trace this mechanism first, to a marked increase in cell cycle-associated transcripts upon Foxc1 ablation, and second, to a downstream reduction in E-cadherin–mediated inter-SC adhesion. Finally, we show that when the old bulge is lost with each hair cycle, overall levels of SC-inhibitory factors are reduced, further lowering the threshold for HFSC activity. Taken together, our findings suggest that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis.

The Hair Follicle Stem Cell Niche: The Bulge and Its Environment

2015 ◽  
pp. 1-26
Author(s):  
Alex B. Wang ◽  
Prachi Jain ◽  
Tudorita Tumbar
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

scholarly journals 687 BMP signaling in the hair follicle stem cell niche regulates hair growth and skin pigmentation

2016 ◽  
Vol 136 (5) ◽  
pp. S122
Author(s):  
J. Lim ◽  
D. Quek ◽  
J. Tan ◽  
C. Clavel
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Hair Growth ◽  
Stem Cell Niche ◽  
Skin Pigmentation ◽  
Bmp Signaling ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

scholarly journals Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Chih-Lung Chen ◽  
Wen-Yen Huang ◽  
Eddy Hsi Chun Wang ◽  
Kang-Yu Tai ◽  
Sung-Jan Lin
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Therapeutic Targeting ◽  
Hair Follicle Stem Cell ◽  
Hair Regeneration ◽  
Functional Complexity ◽  
Cell Niche

scholarly journals The dermal sheath: An emerging component of the hair follicle stem cell niche

2020 ◽  
Author(s):  
Pieter A. Martino ◽  
Nicholas Heitman ◽  
Michael Rendl
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

scholarly journals A Dominant Role of the Hair Follicle Stem Cell Niche in Regulating Melanocyte Stemness

2010 ◽  
Vol 6 (2) ◽  
pp. 95-96 ◽  
Author(s):  
Cédric Blanpain ◽  
Panagiota A. Sotiropoulou
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Dominant Role ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

MESENCHYMAL TNFR1 EXPRESSION PRESERVES THE COLONIC EPITHELIAL STEM CELL NICHE

2021 ◽  
Vol 27 (Supplement_1) ◽  
pp. S7-S8
Author(s):  
Safina Gadeock ◽  
Cambrian Liu ◽  
Brent Polk
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Mesenchymal Cells ◽  
Epithelial Stem Cells ◽  
Epithelial Stem Cell ◽  
Long Term Treatment ◽  
Lgr5 Expression ◽  
Cell Niche

Abstract Tumor necrosis factor (TNF) is a highly expressed cytokine in inflammatory bowel disease (IBD). Although TNF can induce colonic epithelial dysfunction and apoptosis, recent studies suggest that TNF signalling promotes epithelial wound repair and stem cell function. Here we investigated the role of TNF receptor 1 (TNFR1) in mediating TNF’s effects on colonic epithelial stem cells, integral to mucosal healing in colitis. We demonstrate that Tnfr1-/- mice exhibit loss in Lgr5 expression (-52%, p<0.02; N=6) compared to wildtype (WT) controls. However, the opposite result was found in vitro, wherein murine Tnfr1-/- colonoids demonstrated a significant increase in Lgr5 expression (66%, p<0.007; N=6) compared to WT colonoids. Similarly, human colonoids treated with an anti-TNFR1 antibody also demonstrated an increase in Lgr5 expression, relative to IgG controls. To resolve the contradiction in the in vivo versus in vitro environment, we hypothesized that mesenchymal TNFR1 expression regulates the epithelial stem cell niche. To determine the relationships between these cell types, we co-cultured WT or Tnfr1-/- colonoids with WT or Tnfr1-/- colonic myofibroblasts (CMFs). We found that epithelial Lgr5 expression was significantly higher (by 52%, p<0.05; N=3) when co-cultured with WT compared to TNFR1-/- myofibroblasts. The loss of TNFR1 expression in vivo increases the number of αSMA+ mesenchymal cells by nearly 56% (N=6) but considerably reduces the pericryptal PDGFRα+ cells, suggesting modifications in mesenchymal populations that contribute to the epithelial stem cell niche. Functionally, primary Tnfr1-/--CMFs displayed PI3k (p<0.001; N=3) and MAPK (p<0.01; N=3)-dependent increases in migration, proliferation, and differentiation, but RNA profiling demonstrated by diminished levels of stem cell niche factors, Rspo3 (-80%, p<0.0001; N=6) and Wnt2b (-63%, p<0.008; N=6) compared to WT-CMFs. Supplementation with 50ng recombinant Rspo3 for 5 d to Lgr5-GFP organoids co-cultured with TNFR1-/--CMFs restored Lgr5 expression to wildtype levels. Therefore, TNFR1-mediated TNF signalling in mesenchymal cells promotes their ability to support an epithelial stem cell niche. These results should motivate future studies of the stem cell niche in the context of long-term treatment with anti-TNF therapies.

Lymphatic vessels as a stem cell niche

Science ◽  
2019 ◽  
Vol 366 (6470) ◽  
pp. 1193-1194
Author(s):  
Natasha L. Harvey
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Lymphatic Vessels ◽  
Cell Niche
Sign in / Sign up

Export Citation Format

Share Document