scholarly journals Association of cognitive dysfunction with neurocirculatory abnormalities in early Parkinson disease

Neurology ◽  
2012 ◽  
Vol 79 (13) ◽  
pp. 1323-1331 ◽  
Author(s):  
J.-S. Kim ◽  
Y.-S. Oh ◽  
K.-S. Lee ◽  
Y.-I. Kim ◽  
D.-W. Yang ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Cognitive Dysfunction

Association between White Matter Lesions and Non-Motor Symptoms in Parkinson Disease

2018 ◽  
Vol 18 (2-3) ◽  
pp. 127-132 ◽  
Author(s):  
Jeong-Yoon Lee ◽  
Ji Sun Kim ◽  
Wooyoung Jang ◽  
Jinse Park ◽  
Eungseok Oh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Parkinson Disease ◽  
Cognitive Dysfunction ◽  
Rating Scale ◽  
White Matter Lesions ◽  
Motor Dysfunction ◽  
Motor Symptoms ◽  
Non Motor Symptoms

Background: There are only few studies exploring the relationship between white matter lesions (WMLs) and non-motor symptoms in Parkinson disease (PD). This study aimed to investigate the association between WMLs and the severity of non-motor symptoms in PD. Methods: The severity of motor dysfunction, cognitive impairment, and non-motor symptoms was assessed by various scales in 105 PD patients. We used a visual semiquantitative rating scale and divided the subjects into four groups: no, mild, moderate, and severe WMLs. We compared the means of all scores between the four groups and analyzed the association between the severity of WMLs and the specific domain of non-motor symptoms. Results: The non-motor symptoms as assessed by the Non-Motor Symptoms Scale, Parkinson’s Disease Questionnaire (PDQ-39), Parkinson’s Disease Sleep Scale, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Neuropsychiatric Inventory (NPI), and Parkinson Fatigue Scale (PFS) were significantly worse in the patients with moderate and severe WMLs than in those without WMLs. Compared with the no WML group, the scores for motor dysfunction were significantly higher in the mild, moderate, and severe WML groups. The scores for cognitive dysfunction were significantly higher in the patients with severe WMLs than in those without WMLs. The severity of WMLs showed linear associations with PFS, BDI, BAI, NPI, and PDQ-39 scores. The severity of WMLs also correlated linearly with scores for motor and cognitive dysfunction. Conclusions: Among the non-motor symptoms, fatigue, depression, anxiety, and quality of life were significantly affected by WMLs in PD. Confirmation of the possible role of WMLs in non-motor symptoms associated with PD in a prospective manner may be crucial not only for understanding non-motor symptoms but also for the development of treatment strategies.

Cognitive dysfunction and dementia in Parkinson disease

2007 ◽  
Vol 22 (S17) ◽  
pp. S358-S366 ◽  
Author(s):  
Nuria Caballol ◽  
Maria J Martí ◽  
Eduardo Tolosa
Keyword(s):  
Parkinson Disease ◽  
Cognitive Dysfunction

scholarly journals Optical coherence tomography and cognitive dysfunction in Parkinson disease

2019 ◽  
Vol 55 (1) ◽  
Author(s):  
Takwa H. M. Elkhatib ◽  
Noha A. Hashim ◽  
Engy M. Emad ◽  
Hossam Zein ◽  
Lamiaa El-aidy
Keyword(s):  
Optical Coherence Tomography ◽  
Parkinson Disease ◽  
Cognitive Dysfunction ◽  
Optical Coherence

Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea

Neurology ◽  
2017 ◽  
Vol 88 (12) ◽  
pp. 1120-1128 ◽  
Author(s):  
Victoria P. Mery ◽  
Priti Gros ◽  
Anne-Louise Lafontaine ◽  
Ann Robinson ◽  
Andrea Benedetti ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Parkinson Disease ◽  
Movement Disorder ◽  
Cognitive Dysfunction ◽  
Rating Scale ◽  
Apnea Hypopnea Index ◽  
Obstructive Sleep ◽  
Intermittent Hypoxemia ◽  
Osa Treatment

Objective:To assess the association between obstructive sleep apnea (OSA) and nonmotor symptoms (NMS), including cognitive dysfunction, in patients with Parkinson disease (PD).Methods:Patients with idiopathic PD, recruited from a movement disorder clinic, underwent overnight polysomnography. OSA was defined as an apnea-hypopnea index (AHI) ≥15/h. PD severity was assessed using the Hoehn & Yahr (H&Y) scale and the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). NMS were assessed using the Montreal Cognitive Assessment (MoCA), Epworth Sleepiness Scale (ESS), Fatigue Severity Scale, Apathy Scale, Beck Depression Inventory, Hospital Depression and Anxiety Scale, and PD sleep Scale.Results:Sixty-seven patients (61.2% male), mean age 64.4 (SD 9.9) years and motor MDS-UPDRS 21.9 (12.6) using levodopa equivalent dose (LED) 752.4 (714.6) mg/d, were studied. OSA occurred in 47 patients (61.6%, mean AHI 27.1/h, SD 20.2/h), and NMS in 57 patients (85%). ESS and MoCA were associated with the AHI (ESS β = 0.0670, p = 0.031; MoCA β = −0.0520, p = 0.043, adjusted for age, sex, body mass index, LED, and H&Y). ESS was associated with respiratory arousals (β = 0.1015, p = 0.011) and intermittent hypoxemia (β = 0.1470, p = 0.006). MoCA was negatively associated with respiratory arousals (β = −0.0596, p = 0.049) but not intermittent hypoxemia.Conclusions:OSA is associated with sleepiness and cognitive dysfunction in PD, suggesting that OSA may be a reversible contributor to these NMS. Further studies will be required to evaluate whether OSA treatment can improve excessive sleepiness and cognitive dysfunction in PD.

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