Influence of Solvent and Counter Ion on Copper Complexes with N-Alkyl-Pyridine-2-Carboxamides as Studied by Electrospray Ionization Mass Spectrometry

2006 ◽  
Vol 12 (5) ◽  
pp. 311-316 ◽  
Author(s):  
Rafał Frański ◽  
Karolina Klonowska-Wieszczycka ◽  
Aleksandra Borowiak-Resterna ◽  
Andrzej Olszanowski
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Copper Complexes ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Counter Ion ◽  
Influence Of Solvent

scholarly journals Copper complexes formed by 3,5-bis(2,2′-bipyridin-4-ylethynyl)benzoic acid and its methyl and ethyl esters as studied by electrospray ionization mass spectrometry

2013 ◽  
Vol 11 (12) ◽  
pp. 2066-2075
Author(s):  
Rafał Frański ◽  
Marta Kowalska ◽  
Joanna Czerniel ◽  
Maciej Zalas ◽  
Błażej Gierczyk ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Benzoic Acid ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Copper Complexes ◽  
Copper Cation ◽  
Ethyl Esters ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass

AbstractElectrospray ionization mass spectrometry was used to study the complexes of ligands containing two bipyridine units, namely 3,5-bis(2,2-bipyridin-4-ylethynyl)benzoic acid (1) and its methyl and ethyl esters (2, 3), with copper cation, with CuCl2 as a source of copper. It was found that the type of complexes formed strongly depends on CuCl2 concentration. At lower CuCl2 concentration, the detected complexes were rather simple and some of them were formed upon electrospray ionization conditions e.g. ions [22+Cu2]2+ and [32+Cu2]2+ (complexes ligand-Cu(I) of stoichiometry 2:2) which are analogical to the well known, for quaterpyridine, helical complexes. At higher CuCl2 concentration, the detected complexes were more complicated, and most of them contained copper cations bridged by chlorides. The largest ions were [L2+Cu4Cl6]2+. The CID MS/MS spectra of these ions allowed determination of their mass spectrometric fragmentation pathways and as a consequence their structure elucidation.

scholarly journals Binuclear copper complexes with non-steroidal anti-inflammatory drugs as studied by electrospray ionization mass spectrometry

2012 ◽  
Vol 10 (2) ◽  
pp. 320-326 ◽  
Author(s):  
Kaja Kowcun ◽  
Magdalena Frańska ◽  
Rafał Frański
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Copper Complexes ◽  
Ionization Mass Spectrometry ◽  
Cone Voltage ◽  
Ionization Mass ◽  
Binuclear Copper ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

AbstractThe solutions containing one of the copper salts (CuCl2, Cu(ClO4)2, Cu(NO3)2, and CuSO4) and one of the non-steroidal anti-inflammatory drugs (NSAIDs, ibuprofen, ketoprofen or naproxen) were analyzed by electrospray ionization mass spectrometry. Three of the salts, namely CuCl2, Cu(ClO4)2 and Cu(NO3)2, yielded binuclear complexes of drug:metal stoichiometry 1:2. Existence of the complexes of such stoichiometry has not been earlier observed. For copper(II) chloride the complexes (ions of the type [M-HCOOH+Cu2Cl]+ and [M+Cu2Cl]+, M stands for the drug molecule) were formed in the gas phase. When copper(II) perchlorate or copper(II) nitrate was used, the observed binuclear copper complexes (ions of the type [M-H+Cu2(ClO4)2+CH3OH]+, [M-H+Cu2(ClO4)2]+ and [M-H+Cu2(NO3)2+CH3OH]+, [M-H+Cu2(NO3)2]+) were observed at low cone voltage, thus these complexes must have already existed in the solution analysed. Therefore, such complexes may also exist under physiological conditions.

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