scholarly journals Combined Off-Pump Coronary Revascularization and Lung Resection

2002 ◽  
Vol 45 (3) ◽  
pp. 119-121 ◽  
Author(s):  
Cengiz Köksal ◽  
Sabit Sarıkaya ◽  
Mustafa Zengin ◽  
Ali Atasalihi

Concomittant severe coronary artery disease and lung malignancies occur rarely. Combined conventional coronary artery bypass grafting (CABG) with the use of cardiopulmonary bypass (CPB) with lung resection posses several perioperative and postoperative problems related to extracorporeal circulation and heparinization. The avoidance of CPB may be advantageous by decreasing blood loss, pulmonary complications and hospital stay. Further, exposure to the immunosuppresive and inflammatory effects of CPB may have deleterious impact on tumor growth and dissemination. Off-pump CABG makes the combined procedure safer as it abolishes the complications of CPB. We report two patients with the diagnosis of severe coronary artery disease and lung malignancies, underwent off-pump CABG and lung resections in the same surgical setting.

This case focuses on the use of cardiac stents vs. coronary artery bypass surgery for severe coronary artery disease by asking the question: Should patients with severe coronary artery disease (three-vessel and/or left main disease) be treated with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)? For patients with three-vessel and/or left main coronary artery disease, CABG reduced rates of major cardiovascular and cerebrovascular events compared with PCI. This difference was largely driven by a reduction in the need for repeat revascularization procedures among patients receiving CABG. Patients who received PCI had a lower rate of stroke, however, which may make PCI an attractive option for some patients. In addition, the authors suggest that patients with less complex coronary artery disease (as assessed using the SYNTAX score) may be particularly good candidates for PCI, but this hypothesis requires further validation.


2016 ◽  
Vol 19 (2) ◽  
pp. 048
Author(s):  
Jimmy T. Efird ◽  
William Fenner Griffin ◽  
Stephen W. Davies ◽  
Wesley T. O’Neal ◽  
Patricia B. Crane ◽  
...  

<strong>Background:</strong> Emergent coronary artery bypass grafting (CABG) surgery is often required in the case of severe coronary artery disease, which is refractory to traditional management. The objective of our study was to test the hypothesis that there is seasonal variation in the incidence of emergent CABG.<br /><strong>Methods:</strong> A sinusoidal logistic regression model was used to analyze operative data at our cardiovascular institute of 270 cases spanning 5939 calendar days.<br /><strong>Results:</strong> A cyclic peak risk for emergent CABG was observed for late winter (calendar day 66; P = .036). The odds ratios for the 1-, 2- and 3-month window surrounding this peak were 1.8 (95% CI = 0.94-3.5, P = .072), 1.6 (95% CI = 1.06-2.5, P = .024) and 1.4 (95% CI = 0.9-1.8, P = .066), respectively.<br /><strong>Conclusion:</strong> Our results suggest that a seasonal variation may exist in the incidence of patients presenting with severe coronary artery disease requiring emergent CABG. This information is useful in the scheduling of hospital resources and staff. It also provides important etiology clues underlying coronary artery disease that may lead to future interventions or targeted therapies. <br /><br />


2016 ◽  
Vol 30 (2) ◽  
pp. 61-67
Author(s):  
Khawaja Nasir Uddin Mahmood ◽  
Subhash Chandra Mandal ◽  
Saiful Haque Talukdar

There has been increasing interest in the potential benefit of off-pump coronary artery bypass (OPCAB) surgery when compared to conventional coronary artery bypass (CCAB) using cardiopulmonary bypass (CPB) in the presence of critical left main stem (LMS) Disease. A prospective observational study was conducted from January 2006 to June 2012 in the Department of Cardiac Surgery in the National Institute of Cardiovascular Diseases (NICVD), Dhaka. The study included total 110 patients with LMS disease who underwent CABG. 25 cases were done under CPB and 85 cases were done on beating heart. The two groups had similar baseline characteristics including age, sex, risk-factors, comorbid conditions and extent of coronary artery disease. There was no difference between the groups with respect to mortality, but the incidence of post-operative bleeding (p<0.05) , blood requirement (p d”0.05), inotropic and ventilatory support, intensive care unit (ICU) care and post-operative hospital stay (p<0.05) were significantly reduced when performing off-pump CABG in this high-risk group of patients.Bangladesh Heart Journal 2015; 30(2) : 61-67


Author(s):  
Michael E. Hochman

This chapter provides a summary of the landmark study known as the SYNTAX trial, which compared percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) to treat severe coronary artery disease. This chapter describes the basics of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case.


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