Arterial blood pressure and heart rate response in patients with acute ischemic stroke – Correlation with the severity of cardiovascular autonomic dysfunction

1. The effects of l-arginine on systemic and renal haemodynamics were investigated in conscious dogs. l-Arginine was administered intravenously at doses of 15 and 75 μmol min−1 kg−1 for 20 min. 2. Mean arterial blood pressure, heart rate and cardiac output were not changed significantly by l-arginine infusion. However, l-arginine infusion induced a significant elevation of renal blood flow from 50 ± 3 to 94 ± 12 ml/min (means ± sem, P < 0.01). 3. Simultaneous infusion of NG-monomethyl-l-arginine (0.5 μmol min−1 kg−1) significantly inhibited the increase in renal blood flow produced by l-arginine (15 μmol min−1 kg−1) without significant changes in mean arterial blood pressure or heart rate. 4. Pretreatment with atropine completely inhibited the l-arginine-induced increase in renal blood flow, whereas pretreatment with indomethacin attenuated it (63 ± 4 versus 82 ± 10 ml/min, P < 0.05). 5. A continuous infusion of l-arginine increased renal blood flow in the intact kidney (55 ± 3 versus 85 ± 9 ml/min, P < 0.05), but not in the contralateral denervated kidney (58 ± 3 versus 56 ± 4 ml/min, P > 0.05). 6. These results suggest that intravenously administered l-arginine produces an elevation of renal blood flow, which may be mediated by facilitation of endogenous acetylcholine-induced release of endothelium-derived relaxing factor and vasodilatory prostaglandins.

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Assessment of Baroreflex Mechanism by Joint Analysis of Arterial Blood Pressure and Heart Rate

Springer Proceedings in Physics - International Youth Conference on Electronics, Telecommunications and Information Technologies ◽

10.1007/978-3-030-58868-7_62 ◽

2020 ◽

pp. 565-571

Author(s):

Aleksei A. Anisimov ◽

Nikolai B. Suvorov ◽

Natalia L. Frolova ◽

Aleksandr V. Belov ◽

Elizaveta A. Agapova ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Arterial Blood Pressure ◽

Joint Analysis ◽

Arterial Blood

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The Effects of Pneumoperitoneum on Heart Rate, Mean Arterial Blood Pressure and Cardiac Output of Hypertensive Patients during Laparoscopic Colectomy

Journal of Korean Academy of Nursing ◽

10.4040/jkan.2010.40.3.433 ◽

2010 ◽

Vol 40 (3) ◽

pp. 433

Author(s):

Eun Ju Kim ◽

Haesang Yoon

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Cardiac Output ◽

Arterial Blood Pressure ◽

Laparoscopic Colectomy ◽

Mean Arterial Blood Pressure ◽

Hypertensive Patients ◽

Arterial Blood

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Rhythmic Breath Holding and Its Effect on Arterial Blood Pressure and Its Correlation With Blood Gases

ACTA MEDICA IRANICA ◽

10.18502/acta.v57i8.2425 ◽

2020 ◽

Author(s):

Bharti Bhandari ◽

Manisha Mavai ◽

Yogendra Raj Singh ◽

Bharati Mehta ◽

Omlata Bhagat

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Cardiovascular System ◽

Arterial Blood Pressure ◽

Blood Gases ◽

Total Power ◽

Breath Holding ◽

Single Episode ◽

Arterial Blood ◽

Maximum Inspiration

A single episode of breath-holding (BH) is known to elevate the blood pressure, and regular breathing exercise lowers the blood pressure. This prompted us to investigate how a series of BH epochs would affect the cardiovascular system. To observe arterial blood pressure (ABP) and heart rate (HR) changes associated with a series of “BH epochs” following maximum inspiration and maximum expiration and find the underlying mechanisms for the change by autonomic activity. Thirty-five healthy young adults were instructed to hold their breath repetitively, for 5 minutes, in two patterns, one following maximum inspiration and other following maximum expiration. ABP and ECG (for Heart Rate Variability) were continuously recorded at rest and during both the maneuvers. Capillary blood gases (BG) were zanalyzed at baseline and at the breakpoint of the last epoch of BH. ABP rose significantly at the breakpoint during both the maneuvers. No change in HR was observed. There was significant fall in PO2 from 94.7 (4.1) mmHg at baseline to 79.1 (9.0) mmHg during inspiratory and 76.90 (12.1) mmHg during expiratory BH. Similarly, SPO2 decreased from 96.3 (1.9) % at baseline to 95.4 (1.5) % and 94.5 (2.7) % during inspiratory and expiratory BH, respectively. Rise in PCO2 from 39.5(3.1) mmHg at baseline to 42.9 (2.7) mmHg and 42.1 (2.8) mmHg during inspiratory and expiratory BH respectively was observed. There was no significant correlation between blood gases and arterial blood pressure. Among HRV parameters, a significant decrease in SDNN, RMSSD, HFnu, total power and SD1/SD2 and the significant increase in LFnu, LF/HF and SD2 were observed during both BH patterns. Rhythmic BH patterns affect the cardiovascular system in similar way as a single episode of BH. Sympathetic overactivity could be the postulated mechanism for the same. © 2019 Tehran University of Medical Sciences. All rights reserved. Acta Med Iran 2019;57(8):492-498.

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