This chapter assesses how Jonathan Demme's adaptation brought about a seismic change in the horror film genre of the 1990s; it performed a similar function for the crime narrative. The acclaim that the film enjoyed, both critically and commercially, was unprecedented. Particularly noteworthy was the recognition from the staid, conservative members of AMPASS, the industry body whose membership is responsible for bestowing the Academy Awards. It would be easy to say that these wins were exclusively due to the exemplary film-making on display in the film, but not quite accurate — such an impressive use of the medium as was evident would not alone have seduced the conservative Academy members, given the disreputable nature of the horror medium. One factor dictating this sea change in terms of Oscar recognition was the contribution of the actor Anthony Hopkins. Ultimately, what elevates The Silence of the Lambs above its cinematic predecessor is the balancing of the two principal (interlocking) plots: the pursuit and capture of the serial killer Buffalo Bill, and the growing uneasy relationship between the monk-like Hannibal Lecter and his novice ‘pupil’ Clarice Starling.