Gospel parable and Orthodox joke: general and special

The purpose of the article is to reveal the specifics of the Orthodox joke by comparing it with the Gospel parable having a similar function. Methodology. Within the framework of the cultural studies approach, the methods of comparative analysis, induction, and deduction were applied. Scientific novelty. The cultural studies analysis of the correlation between the Gospel parable and the Orthodox joke has been carried out for the first time, both unifying and specific characteristics to each of the phenomena have been identified. Conclusions. An Orthodox joke can be called a parable joke. A modern Orthodox joke has a number of characteristics of a parable: describing the particular situation, it is based on the Gospel teaching; like a parable, it has two layers: a form tied to modernity and a timeless deep religious moral meaning; its main goal is to raise the human mind from earthly to heavenly. At the same time, a number of specific characteristics do not allow us to identify them: the Orthodox joke is created based on modern material; unlike a parable, it involves a laughing reaction. The Orthodox joke (as a joke in form, but with a deep parable content) is able to easily penetrate the consciousness of a secular person who is tuned in to ease and not accustomed to reflection. In this way, Orthodoxy, as in the previous period of its existence, seeks to respond to the needs of the time, transforming the form, but not changing the deep essence of the teaching. Key words: joke, parable, Orthodox anecdote, Gospel parable, metanarrative, modern Orthodox culture, secular society.

Dynamic shapes of the zygote and two-cell mouse and human

ABSTRACT Mouse zygote morphokinetics were measured during interphase, the mitotic period, cytokinesis, and two-cell stage. Sequences of rounder–distorted–rounder shapes were revealed, as were changing patterns of cross section area. A calcium chelator and an actin-disrupting agent inhibited the area changes that occurred between pronuclear envelope breakdown and cytokinesis. During cell division, two vortices developed in each nascent cell and they rotated in opposite directions at each end of the cell, a pattern that sometimes persisted for up to 10 h. Exchange with the environment may have been promoted by these shape and area cycles and persisting circulation in the cytoplasm may have a similar function between a cell's interior and periphery. Some of these movements were sporadically also seen in human zygotes with abnormal numbers of pronuclei and the two-cell stages that developed from these compromised human zygotes.

Conformational Changes in a Macrolide Antibiotic Binding Protein From Mycobacterium smegmatis Upon ADP Binding

Rv3197 (MABP-1), a non-canonical ABC protein in Mycobacterium tuberculosis, has ATPase activity and confers inducible resistance to the macrolide family of antibiotics. Here we have shown that MSMEG_1954, the homolog of Rv3197 in M. smegmatis, has a similar function of conferring macrolide resistance. Crystal structures of apo-MSMEG_1954 (form1 and form 2) and MSMEG_1954 in complex with ADP have been determined. These three structures show that MSMEG_1954 has at least two different conformations we identify as closed state (MSMEG_1954-form 1) and open state (MSMEG_1954-form 2 and MSMEG_1954-ADP). Structural superimposition shows that the MSMEG_1954-form 2 and MSMEG_1954-ADP complex have similar conformation to that observed for MABP-1 and MABP-1-erythromicin complex structure. However, the antibiotic binding pocket in MSMEG_1954-form 1 is completely blocked by the N-terminal accessory domain. When bound by ADP, the N-terminal accessory domain undergoes conformational change, which results in the open of the antibiotic binding pocket. Because of the degradation of N terminal accessory domain in MSMSG_1954-form 2, it is likely to represent a transitional state between MSMEG_1954-form 1 and MSMEG_1954-ADP complex structure.

Morphological Means in Russian: Clarification of the Concept

The concept of “morphological / grammatical means” is widely used in studies on the Russian language, although there is no generally accepted interpretation. This work analyzes the reflection of this concept in Russian studies and clarifies the status of those linguistic units that are traditionally referred to as morphological means: form-building affixes, alternating sounds (internal inflection), stress, supplementary word stems, auxiliary words, intonation, as well as word order. Our research has shown that these linguistic units have different functional status in the morphological structure of the Russian language. First, these are categorical, or actually morphological, means, represented by formative affixes and auxiliary words. They are carriers of morphological meanings in the structure of abstracted morphological forms – the basic units of inflectional Russian morphology. Secondly, a non-categorical means, syncretic and accidental for morphology, are supplementary stems that contain not only lexical, but also morphological meaning and thus duplicate the expression of morphological information in a word form with a form-building affix. Thirdly, these are linguistic units that are not elements of the morphological structure, but have morphological significance, which is manifested in their ability to differentiate homonymous morphological forms in the structure of word forms (alternating sounds and stress) or utterances (intonation). Word order can also perform a similar function. The study allows us to clarify the definition of the concept under consideration: morphological means are linguistic units that are carriers of morphological meanings and constituents of morphological forms.

Conjunctions and clause linkage in Australian languages

This study analyses the role of conjunctions in clause linkage in Australian languages. Conjunctions are seemingly straightforward clause-linking devices, but they remain under-studied, both for Australian languages and from a broader typological perspective. In this study, we propose a functional definition of conjunctions, as set against other resources for clause linkage. We show that this captures not just the prototypical free-standing elements (the equivalents of if, because, but etc.), but also various types of bound markers with a similar function (bound to clause-scoping positions or predicates). We survey the role of conjunctions in a representative sample of 53 Australian languages, showing that they are not a marginal clause linkage resource in Australia, as seems to be assumed in the relevant literature, but often form a major category within clause linkage systems. We also identify a number of areal patterns, based on the size of conjunction inventories and their morphosyntactic features.

Additions to the Knowledge of Corticioid Xylodon (Schizoporaceae, Hymenochaetales): Introducing Three New Xylodon Species from Southern China

Three wood-inhabiting fungal species, Xylodon gossypinus, X. macrosporus, and X. sinensis spp. nov. were collected from southern China, with the similar function to decompose rotten wood, which are here proposed as new taxa based on a combination of morphological features and molecular evidence. Xylodon gossypinus is characterized by the resupinate basidiomata with cotton hymenophore, and ellipsoid basidiospores; X. macrosporus is characterized by the resupinate basidiomata having the cracking hymenophore with pale yellowish hymenial surface, and larger basidiospores 8–10.5 × 7.5–9 µm; and X. sinensis differs by its grandinioid hymenial surface and subglobose basidiospores measuring as 3–5 × 2.5–4 µm. Sequences of ITS and nLSU rRNA markers of the studied samples were generated, and phylogenetic analyses were performed with maximum likelihood, maximum parsimony, and Bayesian inference methods. The ITS+nLSU analysis in Hymenochaetales revealed that the three new species clustered into the Schizoporaceae family, located in genus Xylodon; based on the ITS dataset, X. gossypinus was a sister to X. ussuriensis; X. macrosporus closely grouped with X. follis with a high support; and X. sinensis was retrieved as two sisters to X. attenuatus and X. yarraensis with a lower support.

Does it pay to imitate? No evidence for social gains from lexical imitation

According to an influential hypothesis, people imitate motor movements to foster social interactions. Could imitation of language serve a similar function? We investigated this question in two pre-registered experiments. In Experiment 1, participants were asked to alternate naming pictures and matching pictures to a name provided by a partner. Crucially, and unknown to participants, the partner was in fact a computer program which in one group produced the same names as previously used by the participant, and in the other group consistently produced different names. We found no difference in how the two groups evaluated the partner or the interaction and no difference in their willingness to cooperate with the partner. In Experiment 2, we made the task more similar to natural interactions by adding a stage in which a participant and the partner introduced themselves to each other and included a measure of the participant's autistic traits. Once again, we found no effects of being imitated. We discuss how these null results may inform imitation research.

Bliss beyond All Limit: On the Apabhraṃśa Dohā in Tantric Buddhist Texts

The Apabhraṃśa dohā is a literary medium from Indian antiquity, with early examples appearing in Kālidāsa’s plays around the 5th century and continuing in later Hindi-language Jain and Bhakti works in the early modern period. However, it was within Tantric Buddhist texts and traditions that the dohā truly came into its own as a literary genre. Particularly within the “Yoginī Tantra” strata of the Tantric Buddhist canon, Apabhraṃśa dohās appear in notable and formulaic ways, used within ritual contexts and other significant junctures, signaling the underexamined use of this literary form and its language of composition. This paper examines the use of dohās attributed to the mahāsiddha Saraha as they are used in the Hevajra Tantra, the Buddhakapāla Tantra, and some associated texts. In doing so, this paper demonstrates that as a literary genre, Apabhraṃśa dohās perform a similar function to mantras and dhāraṇīs, but are unique in their attention to phonology and discursive meaning. By examining the uses of these dohās during particular moments of Tantric Buddhist ritual syntax, this paper will then reflect on the later trajectory of these verses after the death of institutional Buddhism in India, and the reasons for their survival.

Impact of IgG isotype on the induction of antibody-dependent cellular phagocytosis of HIV by human milk leukocytes

Approximately 100,000 mother-to-child transmission (MTCT) events of HIV via human milk feeding occur each year (1). However, only about 15% of infants milk-fed by untreated HIV+ mothers become infected, suggesting a protective effect of the milk itself (1, 2). Infants ingest 105-108 maternal leukocytes daily via milk, which remain functional beyond ingestion (3-9). Such function may be elicited by maternal milk antibody (Ab). Though IgA is dominant in milk, most HIV-specific milk Abs are of the IgG subclass, highlighting the importance of investigating the function of each IgG isotype in the milk context (10-16). Though Ab effector function mediated by the constant (Fc) domain via interaction with Fc Receptors (FcRs), such as Ab-dependent cellular phagocytosis (ADCP), are critical in protecting against HIV infection, ADCP is largely unexplored as it relates to mitigation of MTCT (17-21). Presently we report the ADCP activity of milk leukocytes against HIV particles and immune complexes (ICs), using 57 unique samples from 34 women, elicited by IgG1/2/3/4 of monoclonal (m)Ab 246-D. Granulocyte ADCP of HIV was most potent compared to other phagocytes when elicited by IgG1/3/4. IgG1/3 activated granulocytes similarly, exhibiting 1.6x-4.4x greater activity compared to IgG2/4, and a preference for virus compared to ICs. Notably, CD16- monocyte ADCP of a given target were unaffected by isotype, and CD16+ monocytes were poorly stimulated by IgG1. IgG2/4 elicited potent IC ADCP, and in terms of total leukocyte IC ADCP, IgG4 and IgG3 exhibited similar function, with IgG4 eliciting 1.6x-2.1x greater activity compared to IgG1/IgG2, and CD16+ monocytes most stimulated by IgG2. These data contribute to a more comprehensive understanding of Fc-mediated functionality of milk leukocytes, which is critical in order to develop therapeutic approaches to eliminating this route of MTCT, including mucosal administration of mAbs and/or a maternal vaccination aimed to elicit a potent milk Ab response.

The Influence of the Grimm Tales on the Tale Textology of László Arany

László Arany's Eredeti népmesék (Authentic Folktales, 1862) is an iconic collection of folktales. The tales in this publication have been entrenched in the national identity as classic Hungarian folktales, and the narrative style of the tales has been established in the public consciousness as the narrative style of Hungarian folktales. The Arany family's collection of folktales ultimately had a similar function in Hungarian culture as the Kinder- und Hausmärchen of the Brothers Grimm had in Germany, but while the text formation of the Grimm tales had been thoroughly explored by philology, the Arany tales had not been accompanied by folkloristic interpretations or in-depth philological analyses. To László Arany, the fairy tales of the Brothers Grimm were the ideal, which he indicated in his many theoretical writings as well as his role as a collector and editor of tales. To form the individual texts found in Eredeti népmesék, László Arany used the tale manuscripts transcribed by his mother and sister in the 1850s, modifying them considerably, primarily by employing stylistic devices, many of which can also be observed in the work of the Grimms. This essay examines the extent to which László Arany's editorial and text formation practices were determined by the textological practice developed by the Brothers Grimm, and ultimately the extent to which the stylistic ideals of fairy tales developed by the Grimms contributed to the development of the written, literary version of Hungarian folktales.