4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (ETFBO) serves as a trifluoromethyl-containing building block for the preparation of trifluoromethyl-substituted thiophenes, furans, pyrrols, and piperazines. Key steps are an addition–elimination reaction to ETFBO followed by the thiazolium-catalyzed Stetter reaction. The scope of this chemistry was demonstrated in a new synthetic approach towards the COX-2 selective, nonsteroidal anti-inflammatory drug Celebrex® (celecoxib).
Etoricoxib is an oral nonsteroidal anti-inflammatory drug (NSAID). It acts as a selective cyclo-oxygenase-2 (COX-2) inhibitor with anti-inflammatory, analgesic and antipyretic properties. Etoricoxib is available as a tablet formulation in strengths of 60
mg, 90 mg or 120 mg.
Pharmacology of Meloxicam, A New Non-Steroidal Anti-Inflammatory Drug with an Improved Safety Profile Through Preferential Inhibition of COX-2