scholarly journals Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition

eNeuro ◽  
2022 ◽  
pp. ENEURO.0270-21.2021
Author(s):  
Stuart A. Williams ◽  
Miriam Gwilt ◽  
Rebecca Hock ◽  
Charlotte Taylor ◽  
Joanna Loayza ◽  
...  
Keyword(s):  
Fear Conditioning ◽  
Latent Inhibition

Effect of the NMDA antagonist MK-801 on latent inhibition of fear conditioning

2012 ◽  
Vol 102 (4) ◽  
pp. 488-494 ◽  
Author(s):  
Luis M. Traverso ◽  
Gabriel Ruiz ◽  
Luis G. De la Casa
Keyword(s):  
Fear Conditioning ◽  
Latent Inhibition ◽  
Nmda Antagonist ◽  
Mk 801

scholarly journals EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli

2019 ◽  
Vol 34 (1) ◽  
pp. 145-147
Author(s):  
Helen Joan Cassaday ◽  
Karen Elizabeth Thur
Keyword(s):  
Fear Conditioning ◽  
Latent Inhibition ◽  
Conditioned Suppression ◽  
Conditioning Procedure ◽  
Conditioned Stimuli ◽  
Receptor Antagonists ◽  
Clinical Model ◽  
Attentional Switching

Activation of 5-hydroxytyptamine6 (5-HT6) receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-like’ action and is known to be modulated by 5-hydroxytyptamine. In the present study, LI was shown in a fear conditioning procedure that measured suppression of drinking after conditioning with footshock. In two experiments (each n = 48) it was shown that pre-exposure to both light- and noise-conditioned stimuli reduced conditioned suppression relative to the corresponding non-pre-exposed control. However, counter to prediction, LI was intact after treatment with the 5-HT6 agonist EMD386088 (5 mg/kg).

scholarly journals Reward devaluation disrupts latent inhibition in fear conditioning

2017 ◽  
Vol 46 (1) ◽  
pp. 49-59 ◽  
Author(s):  
Luís Gonzalo De la Casa ◽  
Auxiliadora Mena ◽  
Juán Carlos Ruiz-Salas ◽  
Esperanza Quintero ◽  
Mauricio R. Papini
Keyword(s):  
Fear Conditioning ◽  
Latent Inhibition
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