scholarly journals Nicotinic Acetylcholine Receptors Interact with Dopamine in Induction of Striatal Long-Term Depression

2002 ◽  
Vol 22 (7) ◽  
pp. 2541-2549 ◽  
Author(s):  
John G. Partridge ◽  
Subbu Apparsundaram ◽  
Greg A. Gerhardt ◽  
Jennifer Ronesi ◽  
David M. Lovinger
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Long Term Depression ◽  
Nicotinic Acetylcholine

Cholinergic Currents in Leg Motoneurons of Carausius morosus

2010 ◽  
Vol 103 (5) ◽  
pp. 2770-2782 ◽  
Author(s):  
Eugênio E. Oliveira ◽  
Andreas Pippow ◽  
Vincent L. Salgado ◽  
Ansgar Büschges ◽  
Joachim Schmidt ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptor ◽  
Stick Insect ◽  
Fluorescent Label ◽  
Receptor Ligands ◽  
Nicotinic Acetylcholine ◽  
Carausius Morosus ◽  
Unequivocal Identification

We used patch-clamp recordings and fast optical Ca2+ imaging to characterize an acetylcholine-induced current ( IACh) in leg motoneurons of the stick insect Carausius morosus. Our long-term goal is to better understand the synaptic and integrative properties of the leg sensory-motor system, which has served extremely successfully as a model to study basic principles of walking and locomotion on the network level. The experiments were performed under biophysically controlled conditions on freshly dissociated leg motoneurons to avoid secondary effects from the network. To allow for unequivocal identification, the leg motoneurons were backfilled with a fluorescent label through the main leg nerve prior to cell dissociation. In 87% of the motoneurons, IACh consisted of a fast-desensitizing ( IACh1) and a slow-desensitizing component ( IACh2), both of which were concentration dependent, with EC50 values of 3.7 × 10−5 and 2.0 × 10−5 M, respectively. Ca2+ imaging revealed that a considerable portion of IACh (∼18%) is carried by Ca2+, suggesting that IACh, besides mediating fast synaptic transmission, could also induce Ca2+-dependent processes. Using specific nicotinic and muscarinic acetylcholine receptor ligands, we showed that IACh was exclusively mediated by nicotinic acetylcholine receptors. Distinct concentration–response relations of IACh1 and IACh2 for these ligands indicated that they are mediated by different types of nicotinic acetylcholine receptors.

Up-Regulation of Brain Nicotinic Acetylcholine Receptors in the Rat during Long-Term Self-Administration of Nicotine: Disproportionate Increase of the α6 Subunit

2004 ◽  
Vol 65 (3) ◽  
pp. 611-622 ◽  
Author(s):  
Steven L. Parker ◽  
Yitong Fu ◽  
Kathleen McAllen ◽  
Jianhong Luo ◽  
J. Michael McIntosh ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Self Administration ◽  
Nicotinic Acetylcholine
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