scholarly journals Report of the Korean Association of External Quality Assessment Service on Therapeutic Drug Monitoring and Toxicology (2015–2019)

2020 ◽  
Vol 42 (4) ◽  
pp. 183-193
Author(s):  
Hyun-Ki Kim ◽  
Dae-Hyun Ko ◽  
Tae-Dong Jeong ◽  
Eun Suk Shin ◽  
Jeong-Ho Kim ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Quality Assessment ◽  
Drug Monitoring ◽  
External Quality Assessment ◽  
Therapeutic Drug ◽  
External Quality

How appropriate is therapeutic drug monitoring for lithium? Data from the Belgian external quality assessment scheme

2015 ◽  
Vol 48 (9) ◽  
pp. 617-621 ◽  
Author(s):  
I.K. Delattre ◽  
P. Van de Walle ◽  
C. Van Campenhout ◽  
H. Neels ◽  
A.G. Verstraete ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Quality Assessment ◽  
Drug Monitoring ◽  
External Quality Assessment ◽  
Therapeutic Drug ◽  
External Quality ◽  
External Quality Assessment Scheme

Precision and accuracy of commercial assays for vancomycin therapeutic drug monitoring: evaluation based on external quality assessment scheme

2020 ◽  
Author(s):  
Chao-Yang Chen ◽  
Meng-Ya Li ◽  
Ling-Yun Ma ◽  
Xing-Yu Zhai ◽  
Dao-Huang Luo ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Quality Assessment ◽  
Bacterial Infections ◽  
External Quality Assessment ◽  
Detection Methods ◽  
Therapeutic Drug ◽  
External Quality ◽  
External Quality Assessment Scheme ◽  
Percentage Difference ◽  
Precision And Accuracy

Abstract Background Vancomycin remains a mainstay of the treatment of Gram-positive bacterial infections. It is crucial to accurately determine vancomycin serum concentration for adequate dose adjustment. Objectives To evaluate the precision and accuracy of commercial assay techniques for vancomycin concentration and to assess the comparability of vancomycin detection methods in Chinese laboratories. Methods Human serum samples spiked with known concentrations of vancomycin were provided to laboratories participating in the external quality assessment scheme (EQAS). Assay methods included chemiluminescence, enzyme immunoassay (EIA) and so on. The dispersion of the measurements was analysed and the robust coefficient of variation (rCV), relative percentage difference (RPD) and satisfactory rate for method groups were calculated. Moreover, performance of the Chinese laboratories was assessed. Results A total of 657 results from 75 laboratories were collected, including 84 samples from 10 Chinese laboratories. The median rCV, median RPD and satisfactory rates classified by methods ranged from 1.85% to 15.87%, −14.75% to 13.34% and 94.59% to 100.00%, respectively. Significant differences were seen in precision, between kinetic interaction of microparticles in solution (KIMS) and other methods, and in accuracy, between enzyme-multiplied immunoassay technique (EMIT), fluorescence polarization immunoassay (FPIA) and other techniques. Vancomycin detection in China mainly depended on the chemiluminescence and EMIT methods, which tended to result in lower measurements. Conclusions Although almost all assays in this study achieved an acceptable performance for vancomycin serum concentration monitoring, obvious inconsistencies between methods were still observed. Chinese laboratories were more likely to underestimate vancomycin concentrations. Thus, recognizing inconsistencies between methods and regular participation in vancomycin EQAS are essential.

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