Rising serum thyroglobulin in the follow-up of patients with differentiated thyroid carcinoma: the role of FDG PET-CT

2014 ◽  
Author(s):  
Paulina Godlewska ◽  
Elzbieta Bruszewska ◽  
Grazyna Lapinska ◽  
Agnieszka Fijolek-Warszewska ◽  
Marek Dedecjus
Keyword(s):  
Thyroid Carcinoma ◽  
Fdg Pet ◽  
Differentiated Thyroid Carcinoma ◽  
Serum Thyroglobulin ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals The role of Tg kinetics in predicting 2-[18F]-FDG PET/CT results and overall survival in patients affected by differentiated thyroid carcinoma with detectable Tg and negative 131I-scan

Endocrine ◽  
2021 ◽  
Author(s):  
Domenico Albano ◽  
Mark Tulchinsky ◽  
Francesco Dondi ◽  
Angelica Mazzoletti ◽  
Francesco Bertagna ◽  
...  
Keyword(s):  
Overall Survival ◽  
Thyroid Carcinoma ◽  
Fdg Pet ◽  
Roc Curves ◽  
Differentiated Thyroid Carcinoma ◽  
Whole Body ◽  
Roc Curve Analysis ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Purpose The aim of this study was to assess the potential role of thyroglobulin (Tg) kinetics in predicting 2-[18F]-FDG-PET/CT results and overall survival (OS) in patients affected by differentiated thyroid carcinoma (DTC) and suspected recurrence. Methods On hundred and thirty-nine patients were retrospectively included. All patients underwent 2-[18F]-FDG-PET/CT due to detectable Tg levels and negative [131I] whole-body scan. The last two consecutive serum Tg measurements before PET/CT were used for Tg-doubling time (TgDT) and Tg-velocity (Tg-vel) calculation. Receiver operating characteristic (ROC) curves were used to determine the optimal cutoff points for Tg, TgDT and Tg-vel for predicting PET/CT results. Results One hundred and fifteen (83%) patients had positive PET/CT for DTC recurrence, while the remaining 24 (17%) negative. Stimulated Tg before PET and Tg-vel were significantly higher in patients with a positive PET/CT scan than negative scan (average Tg 190 vs 14 ng/mL, p = 0.006; average Tg-vel 4.2 vs 1.7 ng/mL/y, p < 0.001). Instead, TgDT was significantly shorter in positive scan (average TgDT 1.4 vs 4.4 years, p < 0.001). ROC curve analysis revealed the best Tg, TgDT and Tg-vel cutoff of 18 ng/mL,1.36 years and 1.95 ng/mL/y. In patients with Tg<18 ng/mL, the PET/CT detection rate was significantly lower in patients with low Tg-vel (p = 0.018) and with long TgDT (p = 0.001). ATA class risk, PET/CT results and Tg before PET were confirmed to be independent prognostic variables for OS. Conclusions Tg kinetics may help to predict 2-[18F]-FDG-PET/CT results in DTC patients with negative [131I]WBS and detectable Tg, especially in case of low-moderate Tg.

scholarly journals Clinical utility of 18F-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinoma

2017 ◽  
Vol 61 (5) ◽  
pp. 416-425 ◽  
Author(s):  
Ji H. Yang ◽  
Rui M. B. Maciel ◽  
Claudia C. D. Nakabashi ◽  
Carolina C. P. S. Janovsky ◽  
Rosalia P. Padovani ◽  
...  
Keyword(s):  
High Risk ◽  
Thyroid Carcinoma ◽  
Fdg Pet ◽  
Clinical Utility ◽  
Differentiated Thyroid Carcinoma ◽  
Large Cohort ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Prognostic Role of 2-[18F]FDG PET/CT Metabolic Volume Parameters in Patients Affected by Differentiated Thyroid Carcinoma with High Thyroglobulin Level, Negative 131I WBS and Positive 2-[18F]-FDG PET/CT

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2189
Author(s):  
Domenico Albano ◽  
Francesco Dondi ◽  
Angelica Mazzoletti ◽  
Pietro Bellini ◽  
Carlo Rodella ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Fdg Pet ◽  
Differentiated Thyroid Carcinoma ◽  
Whole Body ◽  
Prognostic Role ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Metabolic Volume

The clinical and prognostic role of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (2-[18F]FDG PET/CT) in the study of patients affected by differentiated thyroid carcinoma (DTC) with positive serum thyroglobulin (Tg) level and negative [131I] whole-body scan ([131I]WBS) has already been demonstrated. However, the potential prognostic role of semi-quantitative PET metabolic volume features, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), has not yet been clearly investigated. The aim of this retrospective study was to investigate whether the main metabolic PET/CT parameters may predict the prognosis. We retrospectively included 122 patients with a positive 2-[18F]FDG PET/CT for DTC disease after a negative [131I]WBS with Tg > 10 ng/mL. The maximum and mean standardized uptake value (SUVmax and SUVmean), MTV and TLG of the hypermetabolic lesion, total MTV (tMTV) and total TLG (tTLG) were measured for each scan. Progression-free survival (PFS) and overall survival (OS) curves were plotted according to the Kaplan–Meier analysis. After a median follow up of 53 months, relapse/progression of disease occurred in 87 patients and death in 42. The median PFS and OS were 19 months (range 1–132 months) and 46 months (range 1–145 months). tMTV and tTLG were the only independent prognostic factors for OS. No variables were significantly correlated with PFS. The best thresholds derived in our sample were 6.6 cm3 for MTV and 119.4 for TLG. In patients with negative WBS and Tg > 10 ng/mL, 2-[18F]FDG PET/CT metabolic volume parameters (tMTV and tTLG) may help to predict OS.

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