Subacute thyroiditis with coexisting papillary carcinoma - A case report

Abstract Background Pneumatosis intestinalis (PI) is a rare entity which refers to the presence of gas within the wall of the small bowel or colon which is a radiographic sign. The etiology and clinical presentation are variable. Patients with PI may present either with chronic mild non-specific symptoms or with acute abdominal pain with peritonitis. Some cases of intestinal pneumatosis have been reported as adverse events of new oncological treatments such as targeted therapies that are widely used in multiple tumors. Case presentation A 59-year-old caucasian female with radioactive iodine-refractory metastatic thyroid papillary carcinoma with BRAFV600E mutation was treated with dabrafenib and trametinib as a compassionate use. After 4 months treatment, positron emission tomography–computed tomography (PET–CT) showed PI. At the time of diagnosis, the patient was asymptomatic without signs of peritonitis. The initial treatment was conservative and no specific treatment for PI was needed. Unfortunately, after dabrafenib–trametinib withdrawal, the patient developed tumor progression with significant clinical worsening. Conclusions This case report is, in our knowledge, the first description of PI in a patient treated with dabrafenib–trametinib. Conservative treatment is feasible if there are no abdominal symptoms.

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Papillary carcinoma of the thyroid in a 2-year-old: Case report with review of the literature.

International Journal of Pediatric Otorhinolaryngology ◽

10.1016/j.ijporl.2006.07.031 ◽

2006 ◽

Vol 70 (12) ◽

pp. 2130

Keyword(s):

Case Report ◽

Papillary Carcinoma ◽

Review Of The Literature

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Bilateral Florid Papillomatosis of the Nipple: An Unusual Indicator for Metachronous Breast Cancer Development—A Case Report

Case Reports in Oncological Medicine ◽

10.1155/2014/432609 ◽

2014 ◽

Vol 2014 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Walid Sasi ◽

Dibyesh Banerjee ◽

Kefah Mokbel ◽

Anup K. Sharma

Keyword(s):

Breast Cancer ◽

Case Report ◽

Literature Review ◽

Papillary Carcinoma ◽

Rare Case ◽

Benign Disease ◽

Cancer Development ◽

Breast Cancer Development ◽

Histopathological Features ◽

Metachronous Breast Cancer

Adenoma or florid papillomatosis of the nipple (FPN) is a rare benign disease which has histopathological features similar to those of a mammary papillary carcinoma. Here, we report a rare case of bilateral florid papillomatosis of the nipple and breast cancer, with a literature review.

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Case Report: De Quervain’s Thyroiditis as a Long-Term Sequelae Complication to SARS-CoV-2 Infection

Case Reports in Acute Medicine ◽

10.1159/000517705 ◽

2021 ◽

pp. 64-70

Author(s):

Mark Kong ◽

Sarah La Porte

Keyword(s):

Case Report ◽

Thyroid Function ◽

Elevated Serum ◽

Subacute Thyroiditis ◽

Thyroid Function Tests ◽

Thyroid Function Testing ◽

Neck Lump ◽

Function Testing

A 44-year-old man presented with an enlarged painful lower anterior neck lump with elevated serum concentrations of free thyroxine (T4) and tri-iodothyronine (T3), alongside the presence of antithyroid peroxidase antibodies. Prior to presentation, the patient was demonstrating recovery from a SARS-CoV-2 infection that required sedation, intubation, and invasive ventilation in the intensive care unit (ICU) for 11 days. Ultrasound examination of the thyroid demonstrated features of De Quervain’s (subacute) thyroiditis. This corresponded to the clinical picture, and continuous thyroid function tests were arranged. Emerging evidence throughout the SARS-CoV-2 pandemic describes the long-term sequelae of the infection, including developing atypical effects on the thyroid gland. This case report emphasises the association of painful subacute thyroiditis with post-viral infection and its manifestation during recovery from severe SARS-CoV-2, suggesting that follow-up thyroid function testing should be considered in patients discharged from the ICU who develop neck discomfort.

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