Splenic rupture associated with thrombocytopenic purpura caused by infectious mononucleosis. Case report

Splenic Rupture ◽

Thrombocytopenic Purpura ◽

Introducción. La rotura esplénica asociada a la presencia de purpura trombocitopénica causada por mononucleosis infecciosa es extremadamente rara; la evolución de los pacientes con mononucleosis infecciosa asociada al virus de Epstein-Barr es benigna y autolimitada y no requiere intervenciones terapéuticas específicas. El cuadro es bien tolerado y tiene una baja frecuencia de complicaciones.Presentación del caso. Paciente femenino de 12 años de edad con dos días de evolución de dolor abdominal difuso, distensión, náuseas, palidez de tegumentos y fiebre no cuantificada, quien a su ingreso al servicio de urgencias muestra datos de descompensación hemodinámica, lesiones purpúricas y manchas equimoticas en extremidades. Se realizan estudios de laboratorio y gabinete que confirman anemia, trombocitopenia y hematoma esplénico, por lo que se practica laparotomía exploradora ante la posibilidad de hemoperitoneo.Resultados. La paciente presenta esplenomegalia, hematoma subcapsular roto con sangrado de 4000mL y lóbulo accesorio de bazo con rotura esplénica.Conclusiones. La rotura espontánea del bazo es una complicación infrecuente pero posible en enfermedades infecciosas; sin embargo su asociación a purpura trombocitopenica es extremadamente rara.

Fulminant Epstein-Barr virus - infectious mononucleosis in an adult with liver failure, splenic rupture, and spontaneous esophageal bleeding with ensuing esophageal necrosis: a case report

Journal of Medical Case Reports ◽

10.1186/1752-1947-8-35 ◽

2014 ◽

Vol 8 (1) ◽

Cited By ~ 4

Author(s):

Daniel Busch ◽

Sarah Hilswicht ◽

Dominik S Schöb ◽

Klaus T von Trotha ◽

Karsten Junge ◽

...

Keyword(s):

Case Report ◽

Liver Failure ◽

Epstein Barr Virus ◽

Splenic Rupture ◽

Barr Virus ◽

Esophageal Necrosis ◽

Esophageal Bleeding ◽

Epstein-Barr Virus-Induced Infectious Mononucleosis Complicated by Acute Renal Failure: Case Report and Review

Clinical Infectious Diseases ◽

10.1093/clinids/22.6.1009 ◽

1996 ◽

Vol 22 (6) ◽

pp. 1009-1018 ◽

Cited By ~ 30

Author(s):

H. B. Mayer ◽

C. A. Wanke ◽

M. Williams ◽

A. W. Crosson ◽

M. Federman ◽

...

Keyword(s):

Renal Failure ◽

Acute Renal Failure ◽

Case Report ◽

Epstein Barr Virus ◽

Barr Virus ◽

Production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to Epstein–Barr virus primary infection: a case report of a child

SpringerPlus ◽

10.1186/s40064-015-1236-8 ◽

2015 ◽

Vol 4 (1) ◽

Cited By ~ 5

Author(s):

Keiko Nagata ◽

Keisuke Okuno ◽

Marika Ochi ◽

Keisuke Kumata ◽

Hitoshi Sano ◽

...

Keyword(s):

Case Report ◽

Acute Phase ◽

Primary Infection ◽

Epstein Barr Virus ◽

Thyrotropin Receptor ◽

Barr Virus ◽

Thyrotropin Receptor Antibodies ◽

Epstein Barr ◽

Receptor Antibodies

Idiopathic Haemolacria: A Rare Case Report

Journal of Medicine ◽

10.3329/jom.v20i2.42013 ◽

2019 ◽

Vol 20 (2) ◽

pp. 106-108

Author(s):

Goutam Kumar Acherjya ◽

Mohammad Ali ◽

Keya Tarafder ◽

Mostofa Kamal Chowdhury ◽

Md Abdus Salam ◽

...

Keyword(s):

Case Report ◽

Malignant Melanoma ◽

Medical Practice ◽

Rare Case ◽

Epstein Barr Virus ◽

Rare Condition ◽

Thrombocytopenic Purpura ◽

Barr Virus ◽

Rare Case Report ◽

Crying with bloody tear, called haemolacria is a very rare condition in medical practice. There are many conditions such as idiopathic thrombocytopenic purpura, trauma (accidental or induced), factors deficiencies, infections (Epstein Barr virus or bacterial), tumours (malignant melanoma or haemangioma), conjunctival telangiectasia, Rendu-Oslar-Weber disease related to haemolacria. But idiopathic haemolacria may occur in some cases. In our case report, a 17-year-old girl presented with idiopathic bilateral haemolacria and gum bleeding associated with pseudoseizure and psychogenic hyperventilation who was treated and well responded to adequate counselling and Amitriptyline. J MEDICINE JUL 2019; 20 (2) : 106-108

Epstein-Barr Virus-Positive Blastoid Variant of Mantle Cell Lymphoma in an Adult with Recurrent Infectious Mononucleosis-Like Symptoms: A Case Report

International Journal of Hematology ◽

10.1532/ijh97.06178 ◽

2007 ◽

Vol 85 (3) ◽

pp. 219-222 ◽

Cited By ~ 2

Author(s):

Masakazu Higuchi ◽

Tsuyoshi Muta ◽

Ken-nosuke Karube ◽

Tetsuya Eto ◽

Yujiro Yamano ◽

...

Keyword(s):

Case Report ◽

Mantle Cell Lymphoma ◽

Epstein Barr Virus ◽

Cell Lymphoma ◽

Barr Virus ◽

Mantle Cell ◽

Spontaneous splenic rupture secondary to Epstein-Barr Virus-induced infectious mononucleosis

Journal of Pediatric Surgery Case Reports ◽

10.1016/j.epsc.2020.101680 ◽

2020 ◽

Vol 63 ◽

pp. 101680

Author(s):

Sarah Lee ◽

Ann C. Lin ◽

Joanne Baerg ◽

Esther Wu

Keyword(s):

Epstein Barr Virus ◽

Splenic Rupture ◽

Spontaneous Splenic Rupture ◽

Barr Virus ◽

Epstein-Barr virus hepatitis associated withicterus: A case report

Medicinski pregled ◽

10.2298/mpns0604179c ◽

2006 ◽

Vol 59 (3-4) ◽

pp. 179-182 ◽

Cited By ~ 6

Author(s):

Predrag Canovic ◽

Olgica Gajovic ◽

Zoran Todorovic ◽

Zeljko Mijailovic

Keyword(s):

Free Radicals ◽

Case Report ◽

Epstein Barr Virus ◽

Epstein Barr Virus Infection ◽

Barr Virus ◽

Ebv Infection ◽

Hepatic Cells ◽

Epstein Barr ◽

Acute Infectious Mononucleosis

Introduction. Primary Epstein-Barr virus infection (EBVI) in children is usually asymptomatic with seroconversion. If primary infection occurs in adolescents or in adulthood, the most common manifestation is acute infectious mononucleosis. The diagnosis of acute infectious mononucleosis is made by virus and serologic tests. The most important evidence of primary EBV infection includes IgM class antibodies detected by using EBV virus-capsidantigen (EBV VCA) which appears at the beginning of illness and usually lasts 1 to 2 months. Paul Bunnell Davidson test, although non-specific, is still in use today in diagnosis of infectious mononucleosis and for detection of heterophile antibodies. Case report. Acute hepatitis with icterus is a rare clinical manifestation in primary EBV infection. However, sometimes it is the only manifestation of the disease. This is a case report of a patient with EBV hepatitis and icterus associated with long-lasting fever without pharyngitis and lymphadenopathy, which are characteristics of infectious mononucleosis. The etiologic diagnosis was confirmed by positive Paul Bunnell Davidson test and by detection of specific antibodies (class IgM) to EBV VCA in patient's serum. Discussion. The pathogenetic mechanism which causes destruction of hepatic cells and provokes cholestasis during EBV infection, has not been cleared yet. It is supposed that EBV has no direct cytocide effects on hepatic cells, yet destruction of these cells is caused by toxic action of free radicals through lipid peroxidation. Patients with infectious mononucleosis have autoantibodies directed against enzyme superoxide-dismutase which neutralizes enzyme's antioxidant action. As a result of this action, free radicals accumulate in hepatic cells and cause their damage. Conclusion. Icteric forms of EBV infection are rare. In differential diagnosis of icterus caused by infectious agents, one should not forget EBV. .