Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine

2021 ◽  
Author(s):  
David Lee Bernstein
Keyword(s):  
Ventral Tegmental Area ◽  
Mesolimbic Dopamine ◽  
Ventral Tegmental ◽  
Dopamine Signaling

scholarly journals Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine

2017 ◽  
Vol 23 (5) ◽  
pp. 1032-1045 ◽  
Author(s):  
David L. Bernstein ◽  
Preeti S. Badve ◽  
Jessica R. Barson ◽  
Caroline E. Bass ◽  
Rodrigo A. España
Keyword(s):  
Ventral Tegmental Area ◽  
Mesolimbic Dopamine ◽  
Ventral Tegmental ◽  
Dopamine Signaling

scholarly journals The role of dopamine in reward-related behavior: shining new light on an old debate

2020 ◽  
Vol 124 (2) ◽  
pp. 309-311
Author(s):  
Allan R. Wang ◽  
Alexa Groome ◽  
Lara Taniguchi ◽  
Neir Eshel ◽  
Brandon S. Bentzley
Keyword(s):  
Reinforcement Learning ◽  
Ventral Tegmental Area ◽  
Incentive Salience ◽  
Ventral Tegmental ◽  
Dopamine Signaling

The role dopamine plays in reward-related behaviors has been debated for decades. Heymann et al. (Heymann G, Jo YS, Reichard KL, McFarland N, Chavkin C, Palmiter RD, Soden ME, Zweifel LS. Neuron 105: 909–920, 2020) identify subpopulations of dopamine-producing neurons that separately mediate reward association and motivation. Their results help demonstrate that dopamine signaling may partake in both reinforcement learning and incentive salience functions, instantiated by neuropeptide-defined subpopulations of the ventral tegmental area with different projection targets.

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