scholarly journals Diagnostic Accuracy of Benign Salivary Gland Aspiration Cytology - A Study with Histopathological Correlation

2021 ◽  
Vol 8 (03) ◽  
pp. 126-130
Author(s):  
Lekshmi V ◽  
Mini B
Keyword(s):  
Salivary Gland ◽  
Mucoepidermoid Carcinoma ◽  
Needle Aspiration ◽  
Cytological Diagnosis ◽  
Salivary Duct ◽  
Aspiration Cytology ◽  
Duct Carcinoma ◽  
Fine Needle ◽  
Warthin’S Tumour ◽  
Needle Aspiration Cytology

BACKGROUND Fine needle aspiration cytology (FNAC) is commonly used as a safe and minimally invasive diagnostic test in benign salivary gland lesions. Nevertheless, the capacity of aspiration cytology in diagnosing benign lesions in the salivary gland is still disputed because accurate tumour typing is dependent on the quality and yield of the aspirate, as well as the competence of the cytopathologist. We aim to assess the precision of fine needle aspirate in the pre-operative diagnosis of benign salivary gland lesions and compare it with the histopathological findings. METHODS This is a longitudinal study conducted among 45 patients with preoperative cytological diagnosis of benign salivary gland lesions, who were followed-up till surgery with subsequent histopathological examination in Government Medical College, Thrissur, from 1 st January 2013 to 30th June 2015. RESULTS Among the benign neoplasms, 29 out of 30 cases of pleomorphic adenoma were confirmed on histopathology and one was basal cell adenoma. Out of nine cases of Warthin’s tumour, only seven were confirmed by histopathology. Of the remaining two, one was found to be salivary duct carcinoma showing the typical comedo necrosis and the other was found to be low grade mucoepidermoid carcinoma. So, these two cases were found to be false negative. The statistical analysis showed an overall diagnostic accuracy of 95.5 % for benign salivary gland lesions. CONCLUSIONS FNAC is a minimally invasive technique useful in salivary gland lesions. In nonneoplastic lesions surgery can be avoided and in neoplasms appropriate surgery can be planned. An accurate cytological diagnosis is often possible but may sometimes require the expertise of the cytopathology and use of ancillary techniques KEYWORDS Salivary Gland, Fine Needle Aspiration Cytology, Benign Tumours, Pleomorphic Adenoma, Warthin’s Tumour, Mucoepidermoid Carcinoma, Salivary Duct Carcinoma

Profile of Fine-Needle Aspiration Cytology (FNAC) of Salivary Gland Lesions with Histopathological Correlation in a Tertiary Care Hospital of Maharashtra

2021 ◽  
Vol 8 (14) ◽  
pp. 893-898
Author(s):  
Pradip Ramabhau Butale ◽  
Sagar Jagdish Gawai
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Mucoepidermoid Carcinoma ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Histopathological Correlation ◽  
Neoplastic Lesions ◽  
Needle Aspiration Cytology

BACKGROUND Fine needle aspiration cytology (FNAC) is a method for the diagnosis of superficial lesions like swellings of the salivary glands since many years. The present study was undertaken to identify the patterns of salivary gland lesions (SGL) on FNAC and histopathology specimens and also describe the age and sex distribution of SGL. METHODS A total 319 cases of SGL were studied from June 2009 to July 2019 which included both retrospective and prospective cases. A detailed history was taken, clinical and necessary laboratory investigations were done; and then FNAC of salivary gland was done. Histopathology examination of specimens was done whenever available; FNAC and histopathology slides of retrospective cases were reviewed. Correlation between cytomorphology and histomorphology was done only where available. RESULTS The majority of cases was in the age group of 21 - 40 years (42.98 %) with female predominance (53 %) and commonest gland involved was parotid gland (52.97 %) in both the sexes. 138 (43 %) cases were non-neoplastic lesions and 181 (57 %) were diagnosed as neoplastic lesions. Of the 138 non neoplastic lesions, on cytology and histopathology, sialadenitis constituted 110 (79.71 %) cases; most being chronic sialadenitis (107). Out of 181 neoplastic lesions, 142 (77.78 %) were benign while 39 (22.22 %) cases were malignant. Pleomorphic adenoma was the commonest benign neoplasm (71.27 %) and mucoepidermoid carcinoma (66.69 %) was the commonest malignant neoplasm. Histopathological correlation was available in 37 cases. CONCLUSIONS FNAC is useful as an outdoor diagnostic procedure because of the availability of earlier diagnosis in comparison with the histopathological diagnosis. Histopathology correlation is helpful in cases where diagnosis at FNAC is difficult. KEYWORDS FNAC, Salivary Glands, Histopathology, Specimens, Cytomorphology, Sialadenitis, Pleomorphic Adenoma, Mucoepidermoid Carcinoma

Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm

2020 ◽  
Vol 64 (6) ◽  
pp. 520-531 ◽  
Author(s):  
Andrea Ronchi ◽  
Martina Di Martino ◽  
Alessandro Caputo ◽  
Pio Zeppa ◽  
Giuseppe Colella ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Diagnostic Tool ◽  
Fine Needle Aspiration Cytology ◽  
Mucoepidermoid Carcinoma ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Paediatric Patients ◽  
Needle Aspiration Cytology

<b><i>Background:</i></b> Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumour in paediatric population, accounting for 16% of all cases. Patients affected by a previous solid or leukaemic neoplasm during their childhood may develop a second different tumour during the follow-up. In this setting, salivary gland MEC is relatively frequent, accounting for 6% of the second neoplasms in paediatric patients. Consequently, the occurrence of salivary gland nodules in paediatric patients with a previous neoplasm should be considered an event with a high risk of malignancy that poses peculiar diagnostic challenges. <b><i>Summary:</i></b> This study was designed to define clinical and instrumental findings and morphological features of MEC on fine-needle aspiration cytology (FNAC) samples in paediatric patients with and without a previous neoplasm. Five patients under 19 years are included in this series. FNAC was performed in all patients on a parotid nodule. We have identified 2 groups of patients: (a) 2 cases with previous history of malignancy (acute lymphoblastic leukaemia and Hodgkin lymphoma) and (b) 3 cases without previous malignant neoplasms. In all cases, a final diagnosis of MEC was rendered. <b><i>Key Messages:</i></b> MEC may occur as a second malignancy in paediatric patients. FNAC is certainly a valid and accurate diagnostic tool for this type of neoplasm, even in the paediatric age, allowing the correct management of the patients.

scholarly journals Salivary Duct Carcinoma arising from pre-existing Epithelial-Myoepithelial Carcinoma of the parotid gland: Another rare example with Cytological Correlation

2021 ◽  
pp. 01-12
Author(s):  
Hiroshi Harada ◽  
Mizue Sato ◽  
Michiko Ehara ◽  
Akihiko Kawahara ◽  
Tetsuya Koyam ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Needle Aspiration ◽  
Salivary Duct Carcinoma ◽  
Myoepithelial Carcinoma ◽  
Salivary Duct ◽  
Aspiration Cytology ◽  
Duct Carcinoma ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Epithelial Myoepithelial Carcinoma

An extremely exceptional case of salivary duct carcinoma (SDC) arising from pre-existing epithelial-myoepithelial carcinoma (EMC) of the parotid gland is herein described. The patient was a 50-year-old Japanese female, who presented with an asymptomatic mass of the right parotid gland that had been present for approximately 7 years. A superficial lobectomy of the parotid gland was performed and there have been no symptoms of recurrence or distant metastasis during over 10-year follow-up period. Histologically, the tumor was composed of an EMC component having double-layered ducts and invasive nests of myoepithelial clear cells with an SDC component intermingled throughout the lesion, which consisted of eosinophilic pleomorphic cells. Nests of the SDC component were occasionally accompanied by small luminal structures and minimally focalized comedo necrosis, and were immunoreactive for androgen receptor and GCDFP15. Fine needle aspiration cytology showed moderate cellularity, a few three-dimensional or sheet-like clusters, and single dispersed cells with abundant granular cytoplasm in the background. Furthermore, hyperchromatic small or flattened cells were identified attaching to the periphery of the clusters in retrospective observation. Metachromasia was also seen in May-Grunwald Giemsa stain. Keywords: Salivary duct carcinoma; Epithelial-myoepithelial carcinoma; Parotid gland; Dedifferentiation; High-grade transformation; Fine needle aspiration cytology

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