scholarly journals miR-29a-deficiency does not modify the course of murine pancreatic acinar carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (16) ◽  
pp. 26911-26917 ◽  
Author(s):  
James Dooley ◽  
Vasiliki Lagou ◽  
Josselyn E. Garcia-Perez ◽  
Uwe Himmelreich ◽  
Adrian Liston
Keyword(s):  
Acinar Carcinoma

Secretagogue Response in Single Cells of a Transplantable Pancreatic Acinar Carcinoma

1986 ◽  
Vol 155 (11) ◽  
pp. 375-380
Author(s):  
M. D. O’Donnell ◽  
K. F. McGeeney
Keyword(s):  
Single Cells ◽  
Acinar Carcinoma

scholarly journals Sa1341 – Pancreatic Acinar Carcinoma Has Distinct Mutation Patterns Than Pdac and Neuroendocrine Tumor

2019 ◽  
Vol 156 (6) ◽  
pp. S-320
Author(s):  
Yan Bi ◽  
Yuanhuang liu ◽  
Michael B. Wallace ◽  
Massimo Raimondo ◽  
John Stauffer ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Acinar Carcinoma

Abstract 817: Pancreatic acinar carcinoma - a rare entity with a targetableBRAF V600Emutation

2020 ◽  
Author(s):  
Vaia Florou ◽  
Chris Nevala-Plagemann ◽  
Sean Mulvihill ◽  
Ignacio Garrido-Laguna
Keyword(s):  
Rare Entity ◽  
Acinar Carcinoma

Induction of insulin production in rat pancreatic acinar carcinoma cells by conophylline

2003 ◽  
Vol 57 (8) ◽  
pp. 341-350 ◽  
Author(s):  
K. Umezawa ◽  
A. Hiroki ◽  
M. Kawakami ◽  
H. Naka ◽  
I. Takei ◽  
...  
Keyword(s):  
Carcinoma Cells ◽  
Insulin Production ◽  
Acinar Carcinoma

Muscarinic cholinergic receptors in pancreatic acinar carcinoma of rat

1985 ◽  
Vol 35 (4) ◽  
pp. 493-497 ◽  
Author(s):  
Gérard Taton ◽  
Myriam Delhaye ◽  
StéPhane Swillens ◽  
Jean Morisset ◽  
Louise Larose ◽  
...  
Keyword(s):  
Cholinergic Receptors ◽  
Muscarinic Cholinergic Receptors ◽  
Muscarinic Cholinergic ◽  
Acinar Carcinoma

Carbamylcholine stimulation of protein secretion in pancreatic acinar carcinoma of rat

1982 ◽  
Vol 15 (3) ◽  
pp. 245-253 ◽  
Author(s):  
John R. Warren ◽  
Michael J. Trump ◽  
Janardan K. Reddy ◽  
Michael J. Becich
Keyword(s):  
Protein Secretion ◽  
Acinar Carcinoma ◽  
Stimulation Of

scholarly journals Purification and characterization of α-amylase from rat pancreatic acinar carcinoma. Comparison with pancreatic α-amylase

1987 ◽  
Vol 242 (3) ◽  
pp. 681-687 ◽  
Author(s):  
M K Reddy ◽  
G D Heda ◽  
J K Reddy
Keyword(s):  
Isoelectric Focusing ◽  
Gel Electrophoresis ◽  
Specific Activity ◽  
Peptide Mapping ◽  
Polyacrylamide Gel Electrophoresis ◽  
Alpha Amylase ◽  
Tryptic Digest ◽  
Apparent Homogeneity ◽  
Acinar Carcinoma ◽  
Alpha Amylases

alpha-Amylase was purified to apparent homogeneity from normal pancreas and a transplantable pancreatic acinar carcinoma of the rat by affinity chromatography on alpha-glucohydrolase inhibitor (alpha-GHI) bound to aminohexyl-Sepharose 4B. Recovery was 95-100% for both pancreas and tumour alpha-amylases. They were monomeric proteins, with Mr approx. 54000 on SDS/polyacrylamide-gel electrophoresis. Isoelectric focusing of both normal and tumour alpha-amylases resolved each into two major isoenzymes, with pI 8.3 and 8.7. Tumour-derived alpha-amylase contained two additional minor isoenzymes, with pI 7.6 and 6.95 respectively. All four tumour isoenzymes demonstrated amylolytic activity when isoelectric-focused gels were treated with starch and stained with iodine. Two-dimensional electrophoresis, on SDS/10-20%-polyacrylamide-gradient gels after isoelectric focusing, separated each major isoenzyme into doublets of similar Mr values. Pancreatic and tumour-derived alpha-amylases had similar Km and Ki (alpha-GHI) values, but the specific activity of the tumour alpha-amylase was approximately two-thirds that of the normal alpha-amylase. Although amino acid analysis and peptide mapping with the use of CNBr, N-chlorosuccinimide or Staphylococcus aureus V8 proteinase gave comparable profiles for the two alpha-amylases, tryptic-digest fingerprint patterns were different. Antibodies raised against the purified pancreatic alpha-amylase and tumour alpha-amylase respectively showed only one positive band on immunoblotting after gel electrophoresis of crude extracts of rat pancreas and carcinoma, at the same position as that of the purified enzyme. More than 95% of the alpha-amylase activity in the pancreas and in the tumour was absorbed by an excess amount of either antibody, indicating that normal and tumour alpha-amylases are immunologically identical. The presence of additional isoenzymes in the carcinoma, and dissimilarity of tryptic-digest patterns, may reflect an alteration in gene expression or in the post-translational modification of this protein in this heterogeneously differentiated transplantable pancreatic acinar carcinoma.

scholarly journals No Effect of Dietary Aspartame or Stevia on Pancreatic Acinar Carcinoma Development, Growth, or Induced Mortality in a Murine Model

2017 ◽  
Vol 7 ◽  
Author(s):  
James Dooley ◽  
Vasiliki Lagou ◽  
Tom Dresselaers ◽  
Katinka A. van Dongen ◽  
Uwe Himmelreich ◽  
...  
Keyword(s):  
Murine Model ◽  
Acinar Carcinoma

scholarly journals Clinicopathological Features of Prostate Ductal Carcinoma: Matching Analysis and Comparison with Prostate Acinar Carcinoma

2015 ◽  
Vol 30 (4) ◽  
pp. 385 ◽  
Author(s):  
Aram Kim ◽  
Taekmin Kwon ◽  
Dalsan You ◽  
In Gab Jeong ◽  
Heounjeong Go ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Clinicopathological Features ◽  
Acinar Carcinoma

scholarly journals Neurogenin 3–Directed Cre Deletion of Tsc1 Gene Causes Pancreatic Acinar Carcinoma

Neoplasia ◽  
2014 ◽  
Vol 16 (11) ◽  
pp. 909-917 ◽  
Author(s):  
Li Ding ◽  
Lingling Han ◽  
Yin Li ◽  
Jing Zhao ◽  
Ping He ◽  
...  
Keyword(s):  
Neurogenin 3 ◽  
Tsc1 Gene ◽  
Acinar Carcinoma
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